Objective Dendritic cells (DCs) are potent and specialized antigen-presenting cells,which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Functionally, DCs exist in two ...
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Objective Dendritic cells (DCs) are potent and specialized antigen-presenting cells,which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Functionally, DCs exist in two differentiation stages:immature DCs (imDCs) and mature DCs (mDCs). The imDCs are present in non-lymphoid tissues. Upon capturing antigens, they travel via the blood or lymph to secondary lymphoid organs, and gradu-
Objective The aim of this study is to explore the effect of pre-treatment of curcumin extract on erythrocyte deformable capabilities and erythrocyte band 3 (SLC4A1;EB3). Methods The association between alterations of ...
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Objective The aim of this study is to explore the effect of pre-treatment of curcumin extract on erythrocyte deformable capabilities and erythrocyte band 3 (SLC4A1;EB3). Methods The association between alterations of EB3 and erythrocyte deformable capability induced by hydrogen peroxide has been investigated. The blood samples were divided among 3 groups:(i) control,(ii) pre-treatment either using curcumin extract or vitamin C and (iii) negative control group. The oxidant stress parameters and antioxidant status, erythrocyte deform-
Objective It is well known that capture silk, the main sticky component of the orb web of a spider, plays an important role in the spider's ability to capture preys via adhesion. However, the detailed mechanism wi...
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Objective It is well known that capture silk, the main sticky component of the orb web of a spider, plays an important role in the spider's ability to capture preys via adhesion. However, the detailed mechanism with which the spider achieves its unparalleled high adhesion performance remains elusive. In this work, we combine experiments and theoretical analysis to investigate the adhesion mechanism of the spider silk. In addition to the widely recognized adhesion effect of the sticky glue, we reveal a synergistic enhancement mechanism due to
Objective Compression textiles have been widely applied in compression therapies of various venous disorders. Heterogeneous compression materials are one type of newly designed interventions to deliver proactively pre...
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Objective Compression textiles have been widely applied in compression therapies of various venous disorders. Heterogeneous compression materials are one type of newly designed interventions to deliver proactively pressure to lower limb to reshape pressure magnitudes and distributions, thus avoiding peak local pressure andimproving muscular pumping functions for venous return. This study aims to numerically analyze biomechanical effects of the newly engineered heterogeneous compression shells on skin pressures, internal stresses and tis-
Objective The genetic and proteic regulatory mechanisms underlying the maintenance of embryonic stem cell pluripotency have attracted much attention. However, it has been recognized that the behaviors and functions of...
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Objective The genetic and proteic regulatory mechanisms underlying the maintenance of embryonic stem cell pluripotency have attracted much attention. However, it has been recognized that the behaviors and functions of living organisms are governed not only by their biological properties but also by mechanical mechanisms. Embryonic stem cells (ESCs), which are derived from the inner cell mass (ICM) in blastocyst, live and proliferate in culture conditions as a multi-cellular colony, wherein the cells adhere tightly with their neighbors to
Objective The methods of biomechanics may provide a new viewpoint for understanding natural history of intracerebral hemorrhage (ICH), especially in analyzing the interaction between hematoma and around tissues in ICH...
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Objective The methods of biomechanics may provide a new viewpoint for understanding natural history of intracerebral hemorrhage (ICH), especially in analyzing the interaction between hematoma and around tissues in ICH. This paper presents results from a finite element study of the biomechanics of ICH, with special emphasis on the static stress distribution on different lengths of crack. Constitutive relations of brain tissue, having decisive influence on the research, are inconsistent due to the wide range of variation in experimental protocols
Objective For the special biomolecular composition, microstructure and micromechanics in the interfacial region, surgical reconstruction of ruptured ligament/tendon with soft tissue grafts creates bone-graft interface...
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Objective For the special biomolecular composition, microstructure and micromechanics in the interfacial region, surgical reconstruction of ruptured ligament/tendon with soft tissue grafts creates bone-graft interfaces within bone tunnels, where mismatched properties can result in poor osteointegration and increased rate of graft failure. Therefore, improvements in bone-graft integration are critical to allow for earlier and more aggressive rehabilitation with the hope of promoting a speedier return to normal daily activities. Methods Silk fibroin (SF) so-
Objective:to identify the micro-mechanical changes of articular bone tissues in short period after storage in-20℃environment. Methods The SD rats tibial bone tissues were isolated after animal sacrifice, and the fles...
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Objective:to identify the micro-mechanical changes of articular bone tissues in short period after storage in-20℃environment. Methods The SD rats tibial bone tissues were isolated after animal sacrifice, and the flesh except tibial articular cartilage was carefully removed from the bone. The fresh tibial plateau and cartilage parts were flushed by normal saline before imbedding with epoxy. After epoxy hardening, the solid sample were cut coronally precisely along the middle line of tibial bone. The embedded bone samples were then polished and
Objective The topology and torque of DNA intertwining are critical to DNA organization and the activities of a variety of enzymes such as topoisomerases, polymerases and recombinases. The double strands of B-form DNA ...
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Objective The topology and torque of DNA intertwining are critical to DNA organization and the activities of a variety of enzymes such as topoisomerases, polymerases and recombinases. The double strands of B-form DNA twist naturally once every~10.5 base pairs around the axis of the double-helix. A resisting torque in the DNA can deaccelerate RNA polymerase and increase its pause frequency and continuity during *** sought to observe the twisting of braided DNA molecules and quantify the inner torque. Methods Magnetic
Objective Effects of cadence on lower extremity joint kinetics in cycling have been widely studied, but few studies have analyzed them with respect to both magnitude change and phase shift in the time domain. The purp...
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Objective Effects of cadence on lower extremity joint kinetics in cycling have been widely studied, but few studies have analyzed them with respect to both magnitude change and phase shift in the time domain. The purpose of this study was to investigate the effects of movement speed on lower extremity joint kinetics and motion control in cycling. Methods Sixteen participants cycled at 250 W power at level seated (LS) with two cadences (65 and 110 r/min), respectively. A motion analysis system and a custom instrumented pedal were
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