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检索条件"任意字段=第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议"

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Spatiotemporal distribution of linear microcracks and diffuse microdamage in rat ulnae in response to a daily bout of compressive fatigue loading

Spatiotemporal distribution of linear microcracks and diffus...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Xiyu Liu Xuhui Zhang Zedong Yan Kangning Xie Jing Wang X.Edward Guo Erping Luo Da Jing Fourth Military Medical University 456th Hospital of Chinese People's Liberation Army Xijing Hospital Fourth Military Medical University Bone Bioengineering Laboratory Department of Biomedical EngineeringColumbia University

Objective Microdamage accumulation (including linear microcracks and diffuse microdamage) contributes to impaired skeletal mechanical integrity. Bone can remove microdamage by initiating targeted bone remodeling. However, the spatiotemporal characteristics of microdamage initiation and propagation and its relationship with bone remodeling in response to fatigue loading, especially for more physiologically-relevant daily bout of

关键词： Spatiotemporal distribution of linear microcracks and diffuse microdamage in rat ulnae in response to a daily bout of compressive fatigue loading

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Effects of simulated microgravity on macrophages phagocytosis

Effects of simulated microgravity on macrophages phagocytosi...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Guolin Shi Sufang Wang Nu Zhang Chen Zhang Wenjuan Zhao Hui Yang School of Life Sciences Northwestern Polytechnical University Medical Research Institute Northwestern Polytechnical University Center of Special Environmental Biomechanics&Biomedical Engineering Northwestern Polytechnical University

Objective Since the 1960s, astronauts have started missions in space and consistently shown an increased risk of infection and an overall decrease in immune function due to microgravity condition. The mechanisms underlying these abnormalities are still unclear. To mitigate immune dysfunction in crews on future missions to outer space, it is critical to understand the mechanism of how microgravity influences immune system. Since the1960s, astronauts have started missions in space and consistently shown an increased risk of infection and an

关键词： SMG Effects of simulated microgravity on macrophages phagocytosis

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Mechanical responsive Lnc-DIF inhibits osteoblast differentiation via targeting mir-489-3p

Mechanical responsive Lnc-DIF inhibits osteoblast differenti...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Chong Yin Ye Tian Yan Zhang Dijie Li Lifang Hu Zhihao Chen Fan Zhao Airong Qian School of Life Sciences Northwestern Polytechnical University

Objective Mechanical stimulation plays an important role during the process of skeletal system development and growth. As a new focus of mechanobiology, non-coding RNA takes an important part in regulating gene expression and biological functions under mechanical stimulation. However, its mechanism is still not clear. Methods For the purpose of discovering mechano-sensitive IncRNAs involved in osteogensis, we initiated characterization of IncRNAs by screening the expression levels of IncRNAs in random positioning machine treated me-

关键词： DIF RNA Mechanical responsive Lnc-DIF inhibits osteoblast differentiation via targeting mir-489-3p

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Differential IncRNA/mRNA expression profiling and functional network analysis for MC3T3-E1 cells with hypergravity stimulation

Differential IncRNA/mRNA expression profiling and functional...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Shuping Wei Biao Han Hao Li Lu Yu Yang Zhang Chunqiu Zhang Ruixin Li Xizheng Zhang Institute of Medical Service and Technology Academy of Military Science Department of Anatomy Logistics University of Chinese People's Armed Police Force National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of Technology Central Laboratory Tianjin Stomatological Hospital

Objective Mechanical stimuli play crucial roles in bone remodeling and resorption. Among mechanical stimuli, altered gravity involving microgravity and hypergravity has attracted interest for studying the effects of space flight. These recent findings suggest that hypergravity triggers complex mechanotransduction pathways regulated at both transcriptional and post-transcriptional levels. However, the potential role of long noncoding RNA(IncRNA) on osteoblasts in hypergravity environment still remains largely unclear. The aim of this study is to in-

关键词： IncRNA Differential IncRNA/mRNA expression profiling and functional network analysis for MC3T3-E1 cells with hypergravity stimulation

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Combine morphological and mechanical risk factors for improved carotid plaque progression prediction:A patient-specific magnetic resonance image-based follow-up study

Combine morphological and mechanical risk factors for improv...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Qingyu Wang Dalin Tang Gador Canton Thomas S.Hatsukami Kristen L Billiar Zheyang Wu Chun Yuan School of Biological Science and Medical Engineering Southeast University Mathematical Sciences Department Worcester Polytechnic Institute Department of Mechanical Engineering University of Washington Division of Vascular Surgery University of Washington Biomedical Engineering Department Worcester Polytechnic Institute Department of Radiology University of Washington

Objective It is well known that the benefits from performing carotid endarterectomy for the patients with stenosis severity between 50%and 70%, remains questionable. With a 2%-4%event rate, most of the surgeries were unnecessary. Investigation of plaque development for these patients may aid in making more plausible decision on clinical intervention. We hypothesize that combining morphological and mechanical risk factors may improve plaque progression prediction. In this paper, plaque burden (PB),cap thickness (CT),lipid percent

关键词： PWS Combine morphological and mechanical risk factors for improved carotid plaque progression prediction:A patient-specific magnetic resonance image-based follow-up study image

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Patient-specific FSI models based on IVUS and OCT images with follow-up for more accurate coronary plaque progression predictions

Patient-specific FSI models based on IVUS and OCT images wit...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Xiaoya Guo Dalin Tang David Molony Chun Yang Habib Samady Jie Zheng Gary S.Mintz Akiko Maehara Jian Zhu Genshan Ma Don P.Giddens Department of Mathematics Southeast University Mathematical Sciences Department Worcester Polytechnic Institute Department of Medicine Emory University School of Medicine Mallinckrodt Institute of Radiology Washington University The Cardiovascular Research Foundation Columbia University Department of Cardiology Zhongda HospitalSoutheast University The Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology

Objective Medical imaging resolution has been a limitation for image-based coronary plaque models to obtain accurate morphological and stress/strain data for plaque progression investigation. The resolution for intra-vascular ultrasound (IVUS) images is around 100-150 micron which is not enough to identify vulnerable plaques with thin cap thickness <65 micron. Optical coherence tomography (OCT) has 15-20 um resolution and has become a powerful tool to detect vulnerable plaques with thin fibrous cap. But OCT has limited penetration and

关键词： FSI Patient-specific FSI models based on IVUS and OCT images with follow-up for more accurate coronary plaque progression predictions

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Multi-risk-factor decision-making strategy for improved coronary plaque burden increase prediction:A patient-specific IVUS follow-up study using 3D FSI models

Multi-risk-factor decision-making strategy for improved coro...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Liang Wang Dalin Tang Akiko Maehara Zheyang Wu Chun Yang Muccigrosso David Jie Zheng Richard Bach Kristen L.Billiar Genshan Ma Gary S.Mintz Southeast University Mathematical Sciences Department Worcester Polytechnic Institute Columbia University The Cardiovascular Research Foundation Mallinckrodt Institute of Radiology Washington University Cardiovascular Division Washington University School of Medicine Department of Biomedical Engineering Worcester Polytechnic Institute Department of Cardiology Zhongda HospitalSoutheast University

Objective Plaque progression and vulnerability are influenced by many risk factors. Our goal is to find a simple way to combine multiple risk factors and achieve better plaque development predictions. Methods A sample size of 254 intravascular ultrasound (IVUS) slices with noticeable change of plaque burden was obtained from 9 patients who underwent baseline and follow-up IVUS, and FSI modeling for plaque mechanical condi-

关键词： FSI Multi-risk-factor decision-making strategy for improved coronary plaque burden increase prediction:A patient-specific IVUS follow-up study using 3D FSI models

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Right ventricle material parameter estimation for healthy and patients with tetralogy of fallot using patient-specific in vivo cardiac magnetic resonance-based models with different zero-load diastole and systole morphologies

Right ventricle material parameter estimation for healthy an...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Han Yu Pedro J.Del Nido Tal Geva Chun Yang Zheyang Wu Xueying Huang Rahul H.Rathod Kristen L.Billiar Dalin Tang School of Biological Science&Medical Engineering Southeast University Department.of Cardiac Surgery Boston Children's HospitalDept of SurgeryHarvard Medical School Department of Cardiology Boston Children's HospitalDepartment of PediatricsHarvard Medical School Mathematical Sciences Department Worcester Polytechnic Institute School of Mathematical Sciences Xiamen University Department of Biomedical Engineering Worcester Polytechnic Institute

Objective Patient-specific in vivo ventricle material parameter value determination is important for cardiovascular investigations. Ventricle active contraction caused by sarcomere shortening leads to change of ventricular zero-load configurations. A new modeling approach with different zero-load diastole and systole geometries was used to estimate right ventricle material parameter values for healthy and repaired Tetralogy of Fallot (TOF) patients for potential clinical applications. Methods Cardiac magnetic resonance (CMR) data were obtained from 6

关键词： TOF Right ventricle material parameter estimation for healthy and patients with tetralogy of fallot using patient-specific in vivo cardiac magnetic resonance-based models with different zero-load diastole and systole morphologies

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