目的检测活动性类风湿关节炎(RA)患者血清的DKK-1和RANKL水平,同时了解它们和蛋白聚糖代谢片段及关节破坏的相关性。方法本研究入选87例活动期的RA患者,用DEXA检测患者的BMD,Sharp's法评估患者的双手X线结果,ELISA法检测RA患者的血清DKK-1、RANKL及蛋白聚糖的KS代谢片段,同时检测90例正常人血清的蛋白聚糖代谢片段水平。并收集患者的人口流行病学资料、类风湿因子(RF)、抗CCP抗体、血沉及C-反应蛋白,计算RA患者的疾病活动指数(DAS28)。结果 RA患者的血清蛋白聚糖代谢片段水平明显高于正常对照组(5.3±1.9rig/μ1 VS 2.3±1.5ng/μl,F=48.324,P=0.0001)。血清蛋白聚糖代谢片段水平与DKK-1,RANKI,Sharp评分及抗CCP抗体呈正相关(相关系数分别为:r=0.335,P<0.0001,r=0.226,P=0.001,r=0.301,P=0.0001,r=0.358,P<0.0001)。多元回归分析显示血清蛋白聚糖代谢片段、DKK-1水平和股骨颈BMD是关节侵蚀的危险因素。结论活动性RA患者的血清蛋白聚糖代谢异常升高;同时检测蛋白聚糖代谢片段、血清DKK-1水平及股骨颈BMD可望能预测RA患者的关节破坏
LRRK1 belongs to the ROCO protein family,and contains ankyrin repeats and leucine-rich repeats,a GTPase-like domain of Roc,a COR domain,and a serine/threonine kinase *** have shown that mice with disruption of Lrrk1 g...
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LRRK1 belongs to the ROCO protein family,and contains ankyrin repeats and leucine-rich repeats,a GTPase-like domain of Roc,a COR domain,and a serine/threonine kinase *** have shown that mice with disruption of Lrrk1 gene cause severe osteopetrosis due to dysfunction of osteoclasts(OCs)and impaired bone ***
The role of calcium and vitamin D in the prevention of sex hormone deficiency of which menopause is a major manifestation and age related bone disease has in recent years come under systematic attack on the grounds of...
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The role of calcium and vitamin D in the prevention of sex hormone deficiency of which menopause is a major manifestation and age related bone disease has in recent years come under systematic attack on the grounds of lack of efficacy and *** presentation will review the role of calcium and vitamin D supplementation in the pathophysiology,structural and clinical effects of bone disease of which fracture is a major clinical manifestation.
Background:Osteoporosis is a worldwide epidemiological problem characterized by impaired bone mass and ***,thecorrelation between renin angiotensin system(RAS)and bone structure and metabolism was ***Ⅱ(AngⅡ)was foun...
Background:Osteoporosis is a worldwide epidemiological problem characterized by impaired bone mass and ***,thecorrelation between renin angiotensin system(RAS)and bone structure and metabolism was ***Ⅱ(AngⅡ)was found to induce bone loss
Puberty is an important period for bone mineral *** studies using the conventional Dual Energy X-ray Absorptiometry(DXA)showed a rising trend of areal BMD with age during the pubertal *** limitation with DXA is that i...
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Puberty is an important period for bone mineral *** studies using the conventional Dual Energy X-ray Absorptiometry(DXA)showed a rising trend of areal BMD with age during the pubertal *** limitation with DXA is that it is a projectional investigation confined to areal *** recent advancement in three-dimensional radiographic in-vivo micro-imaging using the high resolution peripheral quantitative computed
Fibroblast growth factor receptor 2(FGFR2)signaling is critical for proper craniofacial development.A gain-of-function mutation in the"c"splice variant of the receptor is associated with Crouzon syndrome,whi...
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Fibroblast growth factor receptor 2(FGFR2)signaling is critical for proper craniofacial development.A gain-of-function mutation in the"c"splice variant of the receptor is associated with Crouzon syndrome,which is characterized by craniosynostosis,the premature fusion of one or more of the cranial vault sutures,leading to neural
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