Aims: This study aimed to use ethylenediaminetetraacetic acid (EDTA) to retrieve paraffin-embedded tissue sections of inflammatory granulomatous lesions and increase the detection rate of tuberculosis (TB)/nontubercul...
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Aims: This study aimed to use ethylenediaminetetraacetic acid (EDTA) to retrieve paraffin-embedded tissue sections of inflammatory granulomatous lesions and increase the detection rate of tuberculosis (TB)/nontuberculous *** to the influence of chemical reagents during the fixation process, the amplification of fluorescent quantitative polymerase chain reaction (PCR) was blocked after DNA extraction, and the results were not ideal.
Liver biopsy plays an important role for the management of patients with HCV, while HCV identification and genotype classification mainly depend on serum based tests,so we hypothesized that RNA in situ hybridization m...
Liver biopsy plays an important role for the management of patients with HCV, while HCV identification and genotype classification mainly depend on serum based tests,so we hypothesized that RNA in situ hybridization may present a valuable way to detect HCV infection in hepatocytes from liver biopsy.36 patient liver FFPE biopsy samples were obtained from302 Military Hospital of China in blinded *** were fixed in10% neutralbuffered formalin (NBF) for24 h and sectioned at a thickness of 5μm.
BACKGROUND: Nonalchoholic fatty liver disease (NAFLD) is a worldwide health problem of clinical significance and increasing *** and fibrosis are characteristic features of NAFLD during its *** change in NAFLD is assoc...
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BACKGROUND: Nonalchoholic fatty liver disease (NAFLD) is a worldwide health problem of clinical significance and increasing *** and fibrosis are characteristic features of NAFLD during its *** change in NAFLD is associated with dysfunction of different cells in the liver, cytokines production, abnormal cell proliferation and influx of inflammation *** better understand the dysfunction and mechanism of steatosis in NAFLD, we evaluated cytokines production and hepatic stellate cell function in NAFLD patient samples and a cell co-culture model.
Competing Interests: The authors have declared that no competing interests ***: The liver contains abundant copies of mitochondrion, which play important roles in physiology and *** have been reported to manipulate th...
Competing Interests: The authors have declared that no competing interests ***: The liver contains abundant copies of mitochondrion, which play important roles in physiology and *** have been reported to manipulate the mitochondrial dynamics including the processes of fusion and fission to facilitate their *** study aims to investigate whether hepatitis E virus (HEV) explore the mitochondrial dynamics to favour its infectious ***: Human liver Huh-7 cells were used to model HEV *** dynamics was observed by confocal immunofluorescent imaging.
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain ***, we report that TAMs secrete abundant Pleiotrophin (PTN) to sti...
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Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain ***, we report that TAMs secrete abundant Pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through the PTN-PTPRZ1 paracrine signaling and thus promote GBM malignant growth.
Body: Background and objective: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and affects more than one-third of the population in the *** immune cells are likely to play a pivotal ...
Body: Background and objective: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and affects more than one-third of the population in the *** immune cells are likely to play a pivotal role in responding to inflammation and metabolic stresses by orchestrating local immune responses through the secretion of cytokines and ***-33, a member of the IL-1 family, can act on immune *** our previous study,we found IL-33 promoted Th2 response and M2 macrophage activation and had a beneficial modulation on expression profiles of fatty acid metabolism genes in livers of die-induced hepatic steatosis in ***-33 treatment attenuated diet-induced hepatic steatosi, but aggravated hepatic fibrosis, in a ST2-dependent manner.
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