It was reported that drug addiction and learning and memory share the common mechanisms in the levels of neurocircuits,neuronal activities,synapse,and intracellular signaling *** role of NMDA receptors,especially the ...
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It was reported that drug addiction and learning and memory share the common mechanisms in the levels of neurocircuits,neuronal activities,synapse,and intracellular signaling *** role of NMDA receptors,especially the receptors containing NR2B subunit,in morphine-induced conditioned place preference（CPP）and Morris water maze（MWM）was in- vestigated in the present *** was used as a paradigm to assess the rewarding effect of mor- phine,and MWM was used to measure the ability and capacity of spatial learning and memory in male SD *** found that ifenprodil(1,3,10 mg·kg,ip),an antagonist highly selective for NR2B containing N-methyl-D-aspartate（NMDA）receptors,blocked the development,consoli- dation as well as the reinstatement of morphine-induced CPP,without evident impairment on the acquisition and retrieval of spatial memory in MWM tests,although the consolidation of spatial mem- ory was disrupted by ifenprodil at the dose of 10 mg·*** results clearly indicate that（1） An active involvement of the NR2B-containing NMDA receptors was indicated in addiction memory induced by morphine conditioning;（2）The NR2B-containing NMDA receptors were not likely in- volved in the acquisition and retrieval of spatial learning and memory;and（3）The NR2B containing NMDA receptors may be considered as a potential target for the treatment of opiate addiction.
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