In the past three decades,China's pharmaceutical market has grown to be the fifth largest in the world and is well positioned to be the second largest within the next *** global pharmaceutical companies are settin...
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In the past three decades,China's pharmaceutical market has grown to be the fifth largest in the world and is well positioned to be the second largest within the next *** global pharmaceutical companies are setting their R&D centers in *** and more global clinical studies and drug registration trials have been conducted in the *** bioanlaysis is playing more and
There are extensive investigations on the fate of organic compounds in plants,animals and *** term of drugs and other xenobiotics was coined to cover all organic compounds that were foreign to the organism under *** e...
There are extensive investigations on the fate of organic compounds in plants,animals and *** term of drugs and other xenobiotics was coined to cover all organic compounds that were foreign to the organism under *** earliest history of drug metabolism is interwoven with the birth of organic *** earliest history of drug metabolism is interwoven with the birth of organic *** the early 1800's,Woehler became interested in potential chemical transformations occurring in the body and
Clearance and its components and in vitro tools to address the clearance issues are *** cytochrome P450 (CYP)-mediated metabolism has long been recognized as the leading metabolism related clearance mechanism,the cont...
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Clearance and its components and in vitro tools to address the clearance issues are *** cytochrome P450 (CYP)-mediated metabolism has long been recognized as the leading metabolism related clearance mechanism,the contribution of metabolism mediated by UDP-glucuronyltransferase(UGT) and aldehyde oxidase(AO),an enzyme of emerging importance in drug
Using ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and gas chromatography coupled to mass spectrometry(GCMS) metabolomic platforms,cells...
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Using ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and gas chromatography coupled to mass spectrometry(GCMS) metabolomic platforms,cells and tissue extracts,serum,and urine,can be probed to discover chemical fingerprints left from various biological processes that result from the administration of drugs or exposure to other *** identification of cellular metabolites can aid in determining the
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