Natural Product is a very important resource for anticancer lead finding. One of the most promising research areas of Shanghai Institute of Materia Medica (SIMM) is novel anticancer agent discovery from Traditional Ch...
详细信息
Natural Product is a very important resource for anticancer lead finding. One of the most promising research areas of Shanghai Institute of Materia Medica (SIMM) is novel anticancer agent discovery from Traditional Chinese Medicine. Camptothecin is a natural alkaloid isolated from Camptotheca acuminata. SIMM developed its derivative 10-hydroxycamptothecin in 1970s and it is still widely used in China. Recently, we synthesized a novel amphoteric 9-substituted camptothecin, Chimmitecan, which confers improved anti-cancer pharmacological profiles both in vitro and in vivo. Salvicine, a natural product derivative from Salvia prionitis, is a new topoisomerase II inhibitor. It also showed prominent anti-multidrug resistance effects and transcription factor c-Jun played a principal role in exerting this effect. Pseudolarix acid B got from Chinese plant Pseudolarix kaempferi. It caused depolymerization of tubulin by binding to a novel site, and abrogated secretion of VEGF due to reducing hypoxia-inducible factor 1 a protein by promoting proteasome pathway, which may responsible for its powerful anti-angiogenic effect.
暂无评论