It is undeniable,cryo-EM entered a new era recently[1],and this is definitely correlated with the appearance of new CMOS-based detectors,which are able to capture the electrons without the need of intermediate phospho...
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It is undeniable,cryo-EM entered a new era recently[1],and this is definitely correlated with the appearance of new CMOS-based detectors,which are able to capture the electrons without the need of intermediate phosphor scintillators and fibre-optic,thus the name direct electron detectors[2].Detector performance is of particular importance in cryo-EM because biological samples under
Amyloid fibrils are highly ordered protein aggregates formed by self-assembly of *** exist broadly in nature from prokaryotic organisms to mammals and are associated not only with neurodegenerative disorders of mammal...
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Amyloid fibrils are highly ordered protein aggregates formed by self-assembly of *** exist broadly in nature from prokaryotic organisms to mammals and are associated not only with neurodegenerative disorders of mammals but also with function roles in bacteria and other *** addition to their nano-scale
＜正＞In this talk,I will review the early contributions to and efforts made by Chinese scientists in the field of molecular cryo-electron *** was their vision,effort and persistence,chiefly led by Senfang Sui（隋森芳...
＜正＞In this talk,I will review the early contributions to and efforts made by Chinese scientists in the field of molecular cryo-electron *** was their vision,effort and persistence,chiefly led by Senfang Sui（隋森芳）,Jiin-Ju Chang（张锦珠）,Yun Li（李云）,Wei Xu（徐伟）,Naiqian Cheng（程乃谦）,Jinqiang Zhang（张景强）and others,mostly
＜正＞Hand-foot-and-mouth disease（HFMD）is a major health concern in China and other Asia Pacific *** China’s mainland,over 3000 fetal cases caused by HFMD have been reported since *** vaccine or drugs is available ...
＜正＞Hand-foot-and-mouth disease（HFMD）is a major health concern in China and other Asia Pacific *** China’s mainland,over 3000 fetal cases caused by HFMD have been reported since *** vaccine or drugs is available *** causative agents
Cryo-electron tomography(Cryo-ET)is a powerful method in the structural biology and cell biology,which provides insights into the macromolecular organization of cells in a close-to-living *** bottleneck of applying th...
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Cryo-electron tomography(Cryo-ET)is a powerful method in the structural biology and cell biology,which provides insights into the macromolecular organization of cells in a close-to-living *** bottleneck of applying this method is the sample preparation,how to make a thin-enough *** cryo-ultramicrotomy,the
The anaphase-promoting complex(APC/C)is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic *** regulation by coactivator subunits,phosphorylation,the mitotic checkpoint complex,and ...
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The anaphase-promoting complex(APC/C)is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic *** regulation by coactivator subunits,phosphorylation,the mitotic checkpoint complex,and interphase inhibitor Emi1 ensures the correct order and timing of distinct cell cycle ***,we used cryo-electron microscopy to determine atomic structures of APC/C-coactivator
The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer’s *** recent structural advances,the transmembrane segments(TMs)of γ-secretase remain to be specifically ***
The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer’s *** recent structural advances,the transmembrane segments(TMs)of γ-secretase remain to be specifically ***
Anthrax toxin,comprising protective antigen(PA),lethal factor(LF)and edema factor(EF),is the major virulence factor of Bacillus anthracis,an agent that causes high mortality in humans and *** forms oligomeric prepores...
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Anthrax toxin,comprising protective antigen(PA),lethal factor(LF)and edema factor(EF),is the major virulence factor of Bacillus anthracis,an agent that causes high mortality in humans and *** forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification,and these pores translocate the
Dihydropyridine receptor（DHPR）and Ryanodine receptor（RyR）,two ion channel proteins in muscle cells,play a key role in excitation-contraction coupling in muscle *** skeletal muscle,contraction initiates from the de...
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Dihydropyridine receptor（DHPR）and Ryanodine receptor（RyR）,two ion channel proteins in muscle cells,play a key role in excitation-contraction coupling in muscle *** skeletal muscle,contraction initiates from the depolarization of surface membrane of muscle cells,which activates the DHPR/L-type Cachannel in surface
＜正＞With the in-depth development of life science,the 3D structure with high resolution of large scale biological samples become more and more *** depended on the development of volume electron microscopy（EM）.Curr...
＜正＞With the in-depth development of life science,the 3D structure with high resolution of large scale biological samples become more and more *** depended on the development of volume electron microscopy（EM）.Currently,there are four volume EM strategys:1)Serial section transmission electron microscopy（ssTEM）;2)
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