The International Symposium for Chinese Medicinal Chemists（iscmc） is a prestigious conference for global Chinese researchers and scientists in the field,which has been set up and organized once every other year sinc...
The International Symposium for Chinese Medicinal Chemists（iscmc） is a prestigious conference for global Chinese researchers and scientists in the field,which has been set up and organized once every other year since 1998.11 International Symposium for Chinese Medicinal Chemists 2018（iscmc2018） will be held on August 24-26,2018,in The Henan Yellow River Yingbin Grand Hotel of
＜正＞The international development of Chinese medicine faces opportunities and challenges:to ensure the safety and efficacy of clinical efficacy in modernization,to control the stability of products in industrializat...
＜正＞The international development of Chinese medicine faces opportunities and challenges:to ensure the safety and efficacy of clinical efficacy in modernization,to control the stability of products in industrialization,and to make the quality control strategy reasonable and *** quality of Chinese medicine is a key scientific issue that affects the clinical efficacy,industrial development and international development of Chinese *** 2010,Macau
4’-Ethvnyl-2-fluoro-2’-deoxy-2’-β-fluoroadenosine(1) was designed and synthesized as a novel HTV reverse *** vitro evaluation demonstrated that nucleoside 1 possesses potent antiviral activity against HIV-1 infect...
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4’-Ethvnyl-2-fluoro-2’-deoxy-2’-β-fluoroadenosine(1) was designed and synthesized as a novel HTV reverse *** vitro evaluation demonstrated that nucleoside 1 possesses potent antiviral activity against HIV-1 infection(ECm = 0.9 nM) and low cytotoxicity(CC>>100μM).
Shanghai Blueray Biophanna focuses on First-in Class drug discovery of WD40 repeat（WDR）*** domain is one of the largest protein families from yeast to human,consisting about 1%total cell *** proteins generally funct...
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Shanghai Blueray Biophanna focuses on First-in Class drug discovery of WD40 repeat（WDR）*** domain is one of the largest protein families from yeast to human,consisting about 1%total cell *** proteins generally function as platform of protein-protein interactions and are involved in a wide range of cellular ***,a subunit of PRC2 complex,is an important member of WDR family and plays critical role of methylating H3 ***,a novel class of EED inhibitors,represented by BRSS4 with great drug-like properties,in vivo efficacy and favorable toxicology profile,will be presented.
Chemical probes are very useful tools for the investigation of drug target and mechanism *** this presentation a series of probes formed from natural products were used for the finding proteins as the target of antivi...
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Chemical probes are very useful tools for the investigation of drug target and mechanism *** this presentation a series of probes formed from natural products were used for the finding proteins as the target of antiviral drugs.
Heterocycles have been well known as life-saving *** efficient synthesis and rapid derivation of Bioactive heterocyclic compounds is very important for drug *** tandem or multicomponent reactions have been developed f...
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Heterocycles have been well known as life-saving *** efficient synthesis and rapid derivation of Bioactive heterocyclic compounds is very important for drug *** tandem or multicomponent reactions have been developed for the synthesis of bioactive heterocyclic compounds.
Computer Aided Drug Design(CADD) has been formally used in the industry for more than30 *** the recent advancement in hardware,software and AI,computational technologies have evolved to play an increasingly important ...
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Computer Aided Drug Design(CADD) has been formally used in the industry for more than30 *** the recent advancement in hardware,software and AI,computational technologies have evolved to play an increasingly important role in the pharmaceutical *** from the start,Hengrui has embraced the technologies and integrated them
Statins are a class of HMG-CoA reductase inhibitors used as lipid-lowering drugs which found to effectively reduce the risk of cardiovascular disease .We have developed two universal statin processes(for atorvastatin,...
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Statins are a class of HMG-CoA reductase inhibitors used as lipid-lowering drugs which found to effectively reduce the risk of cardiovascular disease .We have developed two universal statin processes(for atorvastatin,rosuvastatin and pitavastatin,Figure 1) by 1)kinetic resolution of epoxybutanoate to introduce the C-3 chiral center and diastereoselective bromocylization of homoallylic carbonate to install C-5 chiral center for statin sidechain;2)catalyzed asymmetric Nozaki-Hiyama-Kishi coupling to furnish C-3 chiral center and Pd-catalyzed bromocylization of homoallyl alcohol to construct C-5 chiral center for statin *** processes were optimized for streamlined process and readily for application in industry.
The stems of Tinospora sinensis known as "Kuan-Jin-Teng" are used in traditional medicine for the treatment of rheumatoid arthritis(RA).To uncover the potential mechanism underlying Tinospora sinensis,a netw...
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The stems of Tinospora sinensis known as "Kuan-Jin-Teng" are used in traditional medicine for the treatment of rheumatoid arthritis(RA).To uncover the potential mechanism underlying Tinospora sinensis,a network pharmacology approach has been used in this *** identified 9 targets of 16 compounds from Tinospora sinensis that involve in NF-κB signaling pathway,JAK-STAT signaling pathway and MAPK signaling *** works predict Tinospora sinensis exerted rheumatoid arthritis effects via the key targets MAPKs,SYK,BTK,ZAP70,PRKCQ,IL2,JAK3 and the key biological processes of cytokine *** study provides clues to the researcher who explores pharmacological and molecular mechanism of Tinospora sinensis acting on rheumatoid arthritis.
AMO 579,a potent and selective PDEIOA inhibitor,was identified as Amgen's first generation clinical *** this presentation,we will describe a novel series of structurally distinct azetidine-containing PDEIOA inhibi...
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AMO 579,a potent and selective PDEIOA inhibitor,was identified as Amgen's first generation clinical *** this presentation,we will describe a novel series of structurally distinct azetidine-containing PDEIOA inhibitors as potential back-up molecules to AMO *** will detail the program flow scheme,evolution of the SAR,and especially
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