As the name suggests,non-enzymatic proteins refer to proteins without enzymatic activity such as numerous receptors,ion channels,protein-protein interactions,and so *** involving various tumor targets,the deep study o...
详细信息
As the name suggests,non-enzymatic proteins refer to proteins without enzymatic activity such as numerous receptors,ion channels,protein-protein interactions,and so *** involving various tumor targets,the deep study of these non-enzymatic proteins is of high significance for cancer *** key to understanding the biological processes of
Total synthesis of(±)-wuweizisu C was *** vitro studies indicated that wuweizisu C demonstrated good protective activity against acetaminophen induced liver cell damage,which is superior to the clinical drug bicy...
详细信息
Total synthesis of(±)-wuweizisu C was *** vitro studies indicated that wuweizisu C demonstrated good protective activity against acetaminophen induced liver cell damage,which is superior to the clinical drug bicyclol(Table 1).
The success rate of mechanism-based drug discovery depends on the drug ***,small-molecule drug regulates the function of targets by occupying the active ***,this kind of regulating mechanism cannot be applied to these...
详细信息
The success rate of mechanism-based drug discovery depends on the drug ***,small-molecule drug regulates the function of targets by occupying the active ***,this kind of regulating mechanism cannot be applied to these nonenzymic proteins,which are recognized as undruggable *** regulating the concentration
Acute or chronic inflammation is involved in the development and/or progression of a variety of diseases,including sepsis,acute lung injury,atherosclerosis,pulmonary inflammatory diseases,diabetic complications and **...
详细信息
Acute or chronic inflammation is involved in the development and/or progression of a variety of diseases,including sepsis,acute lung injury,atherosclerosis,pulmonary inflammatory diseases,diabetic complications and ***-expression of pro-inflammatory cytokines and macrophage infiltration are generally observed and play a significant role in the
Steroidogenic CYP enzymes are important in catalyzing the biosynthesis of various hormones including aldosterone,and therefore are promising drug *** studies reveal that besides its classical functions in regulating t...
详细信息
Steroidogenic CYP enzymes are important in catalyzing the biosynthesis of various hormones including aldosterone,and therefore are promising drug *** studies reveal that besides its classical functions in regulating the homeostasis of body fluid and electrolytes,aldosterone also induces ROS and inflammation as well as up-regulates a series of
β-carboline is an important thicyclic indole alkaloid with important antitumor *** this paper,β-carboline compounds with different subsituents was synthesized from tiypsamine,the structures of these compounds were c...
详细信息
β-carboline is an important thicyclic indole alkaloid with important antitumor *** this paper,β-carboline compounds with different subsituents was synthesized from tiypsamine,the structures of these compounds were characterized by mass pectrometry,hydrogen spectrometry and carbon ***,the antitumor activity of these compounds was investigated and the structure-activity relationship was discussed.
Therapeutic interventions that target virulence rather than the survival of the bacterial pathogens have received immense attention,as these approaches allow selective disarming the pathogen and preserving the integri...
详细信息
Therapeutic interventions that target virulence rather than the survival of the bacterial pathogens have received immense attention,as these approaches allow selective disarming the pathogen and preserving the integrity of the host *** Chinese Medicines(TCMs) have been historically used to treat bacterial ***,the molecules responsible for these anti-infective properties and their potential mechanisms of
Proteolysis-Targeting Chimeras are bifunctional small molecules designed to hijack the powerful cellular degradation machinery for inducing targeted protein degradation and this approach has recently gained momentum a...
详细信息
Proteolysis-Targeting Chimeras are bifunctional small molecules designed to hijack the powerful cellular degradation machinery for inducing targeted protein degradation and this approach has recently gained momentum as a new therapeutic strategy for small-molecule drug *** this lecture,I will present our recent research in the design and
Iriomoteolide-13a（1） was isolated from a benthic dinoflagellate Amphidinium sp.（strain KCA09053）. Its complex molecular architecture poses a significant challenge to synthetic *** connection with our on-going rese...
详细信息
Iriomoteolide-13a（1） was isolated from a benthic dinoflagellate Amphidinium sp.（strain KCA09053）. Its complex molecular architecture poses a significant challenge to synthetic *** connection with our on-going research program on diverted total synthesis of marine macrolides such as amphidinolide Y and T2, iriomoteolide-1a, and laingolide
Drug discovery,from its traditional area of lead discovery and optimization,has extended toward two directions:upstream for target identification and validation,and downstream for preclinical *** directions are associ...
详细信息
Drug discovery,from its traditional area of lead discovery and optimization,has extended toward two directions:upstream for target identification and validation,and downstream for preclinical *** directions are associated with discovering new pathogenic pathways or re-evaluating existing *** biology is a new discipline to fulfill such kind of
暂无评论