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检索条件"任意字段=第11届世界华人药物化学研讨会（ISCMC2018）"

共 414 条记录，以下是211-220 订阅

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Development of bacterial β-glucuronidase specific inhibitors to reduce chemo-induced intestinal toxicity and prevent tumorigenesis

Development of bacterial β-glucuronidase specific inhibitor...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Kaiwen Cheng Tianlu Cheng Center for Biomarkers and Biotech Drugs Kaohsiung Medical University

Hepatic glucuronidation is a major route for *** and carcinogens are conjugated with glucuronic acid to increase water solubility and facilitate their subsequent elimination from the ***,the inactive glucuronide conjugates are reactivated back to active metabolite by bacterial β-glucuronidase(PG) in the intestine,thus inducing severe intestinal toxicity and promoting colon ***,inhibiting the intestinal bG activity by a specific eβG inhibitor is potential to protect the intestine from drugs-or carcinogens-induced *** this study,we report on the effects of pyrazolo[4,3-c]quinolines acting as a new class of E coli βG(eβG)-speciflc inhibitors in a pH-dependent ***,the oral administration of 3-amino-4-(4-fluorophenyl amino)-1 H-pyrazolo[4,3-c]quinoline(TCH-3511) combined with chemotherapeutic CPT-11 treatment prevented CPT-11-induced serious diarrhea while maintaining the antitumor efficacy in tumor-bearing ***,TCH-3511 feeding also diminished the formation of intestinal tumor polyp in carcinogenic DMH-treated ***,these results indicate that the TCH-3511 could prevent the reactivation and releasement of drug or carcinogen in the intestine,and thus it is potential a chemotherapy adjuvant and a chemoprevention agent to reduce drug toxicity and to prevent CRC.

关键词： Hepatic glucuronidation bacterial β-glucuronidase chemotherapy-induced diarrhea tumorigenesis chemoprevention

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Recent progress in the discovery of glycine N-methyltransferase(GNMT) inducers and bacteria β-glucuronidase inhibitors

Recent progress in the discovery of glycine N-methyltransfer...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Cherngchyi Tzeng Chihhua Tseng Yehlong Chen Department of Medicinal and Applied Chemistry College of Life ScienceKaohsiung Medical University School of Pharmacy College of PharmacyKaohsiung Medical University

Glycine N-methyltransferase（GNMT） is a tumor suppressor gene for hepatocellular carcinoma（HCC）.Literatures revealed that the expression of GNMT is significantly down-regulated in HCC ***,discovery of GNMT expression inducers will have important implications for the prevention and treatment of ***,we have identified compound 1 as a hit from the drug library of more than 20,000 compounds using a GNMT gene expression-oriented screen *** 1 is capable of inducing GNMT expression strongly with 7.57 folds to control in a concentration of 2.5 μ*** of bacteria β-glucuronidase（eβG） is useful in alleviating drug toxicity（diarrhea etc）of irinotecan（CPT-11）.Recently,compound 2 was identified by HTS as a potent eβG inhibitor with an IC value of 620 *** have also discovered compound 3 by HTS as a selective eβG inhibitor with an IC value of 130 *** optimization of compound 1 and compound 3 leading to the discovery of potential GNMT inducers and potential eβG inhibitors,respectively,will be presented.

关键词： Glycine N-methyltransferase(GNMT) Hepatocellular carcinomas(HCC) Bacteria β-glucuronidase(eβG)

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An NAD(P)H:quinone oxidoreductase 1 responsive and self-immolative prodrug of 5-fluorouracil for safe and effective cancer therapy

An NAD(P)H:quinone oxidoreductase 1 responsive and self-immo...

引用

第11届世界华人药物化学研讨会（iscmc 2018）

作者： Xiang Li Xian Zhang Zhihong Li Qidong You Xiaojin Zhang Jiangsu Key Laboratory of Drug Design and Optimization China Pharmaceutical University

The general goal in anticancer drug development is to achieve highly selective toxicity against cancer cells while simultaneously sparing normal *** strategies are an advanced research area in which nontoxic drugs are carried to cancer tissues and activated by overexpressing enzymes specifically,bringing about controllable drug release in target ***(P)H:quinone oxidoreductase 1(NQO1) is such a cancer-specific cytosolic flavoenzyme that is highly elevated in numerous cancer cells,especially in nonsmall cell lung cancer(NSCLC).NQO1 can catalyze the direct two-electron reduction of a broad range of quinone *** prodrug,composed of an NQO1-responsive trigger group,a self-immolative linker,and the active drug 5-fluorouracil(5-FU),was designed and synthesized for site-specific cancer *** bioreductive activation by NQO1,1 can release the parent drug 5-FU specifically in NQO1-overexpressing cancer *** prodrug exerts comparable antitumor activity and a more favorable safety profile compared with 5-FU both in vitro and in vivo.

关键词： Prodrug NQO1 5-FU Cancer therapy

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Design,synthesis and bioevaluation of substituted triazines as potential dual PI3Kα/mTOR inhibitors

Design,synthesis and bioevaluation of substituted triazines ...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Tingting Wu Shumin Li Jiquan Zhang Lei Tang College of Pharmacy Guizhou Medical University Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D Guizhou Medical University

The PI3 K signaling pathway plays a central role in a broad cellular functions and it is frequently active in various cancers. Recent studies revealed that a high proportion of human cancers relied strongly on P110α for survival and resistance to therapy. Furthermore,it has been demonstrated that the PI3 K pathway is paradoxically activated following selective mTOR. Therefore,the development of dual PBKα/mTOR inhibitors is one of the most promising approaches for cancer *** poor isoform-selectivity may lead to off-target effects compromising therapeutic *** we continued exploring of inhibitors with better isoform-selective profiles based on pyrimidine and triazine scaffolds, the phase Ⅲ candidate PF-05212384 was taken as lead compound,and two series of triazine derivatives have been designed and *** inhibitory activities aganist PI3 Kα and mTOR were ***,their cytotoxicities to various human cancer cell lines have also been evaluated.

关键词： PI3K triazine kinase inhibitor cancer

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Discovery of new cross-class inhibitors against serine and metallo carbapenemases

Discovery of new cross-class inhibitors against serine and m...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Guobo Li West China School of Pharmacy Sichuan University

The rapid emergence and spread of carbapenem-resistant Gram-negative pathogens is a growing problem.[1]One of the most important mechanisms of resistance to carbapenems involves their hydrolysis as catalysed by serine and metallo *** date,clinically useful inhibitors for serine carbapenemases are available;however,there are no equivalent inhibitors for metallo *** virtual screening and crystal structure-guided design,we recently identified new metallo carbapenemase inhibitors.[2-4]Since many bacteria have acquired both serine and metallo carbapenemases,we are interested in developing cross-class inhibitors for serine and metallo *** designed and synthesized a series of(S)-((3-mercapto-2-methyl-propanamido)methyl)boronic acid *** compounds exhibited potent inhibition to multiple metallo carbapenemases(***-2,NDM-1,Shf-I,and GOB-18) and serine carbapenemases(***-2 and OXA-48).Crystallographic analyses revealed that they are positioned to chelate with VIM-2 active site zinc ions and form a covalent bound with the nucleophilic serine of *** cellular activities,selectivity and toxicity of the representative derivatives were also *** work will aid future efforts to develop cross-class inhibitors to combat carbapenemase medicated Gram-negative pathogens.

关键词： Gram-negative Carbapenem Carbapenemase Inhibitor Crystallography

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Environment-sensitive fluorescent agonist for ai-Adrenergic receptor

Environment-sensitive fluorescent agonist for ai-Adrenergic ...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Xiaojun Qin Lupei Du Minyong Li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of PharmacyShandong University

ai-Adrenergic receptors（α-ARs）,as the important members of the superfamily of G protein coupled receptors（GPCRs）,play a crucial role in mediating many physiological effects of the sympathetic nervous *** far,α-ARs are classified into at least three subtypes（α A,α B,and α D） based on their differences intrinsic properties.[1-2]Various studies confirmed that the receptors will internalize upon agonist ***,detecting and real-time imaging of α-ARs in living cell can provide useful information for fully understanding the intrinsic characteristics of each α-AR ***,we developed a novel fluorescent agonist for α-ARs which consist of two parts:agonist of α-ARs that is used to bind withα-ARs via receptor-ligand interaction and fluorophore that can be used to trace α-ARs based on off-on mechanism through the variation of surroundings.[2-4]This results show that fluorescence turn-on can be achieved upon binding of the fluorescent agonist to hydrophobic ligand-binding domain of α-*** addition,the fluorescent agonist could also selectively label α-ARs-transfected HEK293 cells,and real-time monitor internalization of α-AR.

关键词： α1-adrenergic receptor fluorescent turn-on agonist imaging internalization

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Discovery and optimization of the third-generation EGFRT790M inhibitors

Discovery and optimization of the third-generation EGFRT790M...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Yongjia Hao Jiankun Lyu Yufang Xu Honglin Li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science & Technology Guizhou University of Chinese Medicine

Lung cancer,especially non-small cell lung cancer（NSCLC） is one of the most prevalent malignant ***-generation epidermal growth factor receptor（EGFR） inhibitors,gefitinib and erlotinib have achieved initially marked clinical efficacy for NSCLC ***,their clinical benefit was limited by the emergence of acquired resistance mutations,where the T790 M secondary mutation accounts for about 60%.Thus,there is an unmet clinical need to develop third-generation EGFR ***,based on the previous research,we designed and synthesized a novel series of pyrimido[4,5-d] pyrimi dine-2,4（1 H,3 H）-dione *** which,the most potent compound 2 not only demonstrated great inhibitory activity and selectivity for EGFR kinase and H1975 cells in vitro,but also displayed significant antitumor efficiency in H1975 xenograft mouse *** encouraging mutant-selective results suggested that compound 2 might be used as a promising lead compound for further structural optimization as potent and selective EGFR inhibitors.

关键词： EGFR inhibitors design optimization selectivity

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Design,synthesis and biological evaluation of MEK inhibitors as anti-enterovirus 71(EV71) and antitumor agents

Design,synthesis and biological evaluation of MEK inhibitors...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Dandan Xi Chao Wang Ping Xu Department of Medicinal Chemistry School of Pharmaceutical SciencesPeking University

Enterovirus 71（EV71）,a kind of RNA virus of the Enterovirus genus of the Picornaviridae family,is one of the main causes of hand,foot and mouth disease（HFMD）.Inhibitors that target MEK which is one of the vital kinases in Ras/Raf/MEK/ERK pathway,could prevent replication and propagation of EV71 in host cells such as embryonic rhabdomyosarcoma（RD）***,MEK inhibitors have demonstrated bona fide antitumor efficacy and low toxicity in *** designed and synthesized a series of MEK inhibitors based on the coumarin *** compound（20 a） had favorable suppressive activity towards unphosphorylated MEK1 among these derivatives,it could also effectively suppress the expression of EV71 VP1 in RD cells(EC = 1.26 μM and TI > 79),and induce cell apoptosis in MDA-MB-231 cells(IC = 0.034 μM).On the basis of our results,we believe 20 a to be a promising agent or lead compound for further anti-enterovirus 71 and anticancer drug development.

关键词： MEK inhibitor anti-enterovirus 71(EV71) agents antitumor agents

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Design,synthesis and evaluation of environment-sensitive fluorescent inhibitors for aminopeptidase N

Design,synthesis and evaluation of environment-sensitive flu...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Xin Zhou Mingyong Li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of Pharmaceutical SciencesShandong University

Aminopeptidase N(APN) is an important metalloenzyme and widely expressed in many tissues and organs of mammals[1].It can remove amino acids sequentially from the N-terminal of protein or peptide *** with normal cells,APN is highly expressed on the surface of tumor cells and regarded as a tumor biomarker[2].Because of the vital rules in tumor invasion and angiogenesis,the discovery of APN targeted drugs have been always concentrated by medicinal ***,we undertook our efforts on designing and synthesizing novel environment-sensitive fluorescent APN inhibitors with potent APN inhibitory *** on our long-term research experiences on APN inhibitors,we chose an ureido hydroxamic acid-based inhibitor as the lead compound,which has a low IC50 value to APN and a high affinity with *** the reported fluorophore-labeled fluorescent inhibitors,the environment-sensitive fluorophores used in the designed fluorescent inhibitors are also pharmacophores,which will not disturb the binding of inhibitors and *** summary,the environment-sensitive APN fluorescent inhibitors have high inhibitory activity and fluorescence switching properties,which are expected to be both therapeutic and diagnostic for diseases.

关键词： Aminopeptidase N fluorescent inhibitor environment-sensitive

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Discovery of thiazolo-pyrones as potential anti-inflammatory and anti-hepatic fibrosis agents

Discovery of thiazolo-pyrones as potential anti-inflammatory...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Li Lin Ting Tian Huiyun Liu Xu Zhang Fei Li Taihan Li Jiabin Niu Rui Wang Key Laboratory of Preclinical Study for New Drugs of Gansu Province Institute of Biochemistry and Molecular BiologySchool of Basic Medical SciencesLanzhou University

Inflammation is the key process of many lands of diseases including hepatic ***-steroidal anti-inflammatory drugs（NSAIDs） are widely used in the field of anti-inflammatory,analgesic,and other pathological *** the poor selectivity to inhibit relative enzymes and their natural structural characteristics always cause serious side ***,novel anti-inflammatory drugs are still worth to be explored.A series of chiral thiazolo-pyrones with novel structure were obtained with excellent stereoselectivities. The structure-effect-relationship（SAR） map were studied via systematic bioactivity evaluation under standard in vivo and in vitro pharmacological *** compounds showed potent anti-inflammatory activity both in RAW cell assay and in xylene-induced ear edema in mice. Further studies also indicated that these compounds showed potent anti-hepatic fibrosis activity in CC14-induced acute liver damage in *** in both bioactivities have also been ***,these compounds have shown dual anti-inflammatory and anti-fibrotic activity in vivo and in vitro.

关键词： Thiazolo-pyrones COX iNOS anti-inflammatory

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