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检索条件"任意字段=第11届世界华人药物化学研讨会（ISCMC2018）"

共 414 条记录，以下是221-230 订阅

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High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy inhibition and enhanced antitumor immunity in glioblastoma

High-selective HDAC6 inhibitor promotes HDAC6 degradation fo...

引用

第11届世界华人药物化学研讨会（iscmc 2018）

作者： Jiwang Chern School of Pharmacy and Center for Innovative Therapeutics DiscoveryTaiwan University

Glioblastoma is the most fatal type of primary brain cancer,and current treatments for glioblastoma are insufficient HDAC6 is overexpressed in glioblastoma,and siRNA-mediated knockdown of HDAC6 inhibits glioma cell ***,we report a high-selective HDAC6 inhibitor,J22352,which has PROTAC-like property resulted in both p62 accumulation and proteasomal degradation,leading to proteolysis of aberrantly ***6 in *** consequences of decreased HDAC6 expression in response to J223 S2 decreased cell migration,increased autophagic cancer cell death and significant tumor growth ***,J22352 reduced the immunosuppressive activity of PD-L1,leading to the restoration of host anti-tumor *** results demonstrate that J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in ***,this highly selective HDAC6 inhibitor can be considered a potential therapeutic for the treatment of glioblastoma and other cancers.

关键词： Glioblastoma HDAC6 inhibitor autophagic cell death

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Small-molecule organic NIR-Ⅱ dyes for in vivo tumor imaging and image-guided photothermal therapy

Small-molecule organic NIR-Ⅱ dyes for in vivo tumor imaging...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Hui Zhou Xiaodong Zeng Fuchun Xu Xuechuan Hong Medical College Tibet University State Key Laboratory of Virology School of Pharmaceutical SciencesWuhan University

As fluorescence imaging in vivo continues to gain increasing interest and expand within both academic and clinical settings,a transition shifted to longer wavelengths in the second near-infrared window(NIR-II,1000-1700 nm) region could have the clear-cut advantages of deeper tissue imaging,high spatial resolution,and high contrast owing to minimal auto-fluorescence and tissue *** imaging quality,superior lymphatic,deeper brain tumor imaging,and higher tumor-to-background ratios have been achieved recently compared to conventional NIR-I region(750-900 nm).We have explored the design and synthesis of first small-molecule organic NIR-II fluorescent materials CH1055 with favourable water solubility and fast biological ***,a series of novel bright-emission small-molecule NIR-II fluorophores have been synthesized for in vivo tumor imaging,image-guided surgery,osteosarcoma imaging and photothermal therapy.

关键词： Image-guided photothermal therapy Small-molecule organic fluorophores Longer wavelengths in the second near-infrared window Molecular imaging Tumor

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O2-3-aminopropyl diazeniumdiolates suppress progression of highly metastatic triple-negative breast cancer by inhibition of microvescile formation via nitric oxide-based epigenetic regulation

O2-3-aminopropyl diazeniumdiolates suppress progression of h...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Jianbing Wu Fenghua Kang Tian Lv Yihua Zhang Zhangjian Huang State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical University

Currently,there is no effective therapy for treatment of highly metastatic triple-negative breast cancer（TNBC）.Microvesicle（MV） formation is crucial for metastasis of *** we report a novel strategy to inhibit the generation of MVs for intervention of TNBC.O-3-Aminopropyl diazeniumdiolates 3 a-f are designed and synthesized,which can be activated by lysyloxidase over-expressed in TNBC cells. The most active compound 3 f is able to selectively release high levels of NO in TNBC cells,inhibit the cells' proliferation while sparing poor-metastatic breast cancer cells and non-tumor cells,and reduce adhesion,invasion and migration of TNBC cells in ***,3 f significantly suppresses growth and metastasis of implanted TNBC in vivo through attenuating MVs formation by an epigenetic modification of miR-203/RAB22 A expression in an NO-dependent manner,providing the first evidence of NO donor（s） acting as an epigenetic modulator to fight highly metastatic TNBC（Figure 1）.

关键词： TNBC MVs diazeniumdiolates nitric oxide epigenetic regulation

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In vitro SAR and mechanism studies of 1-(3-hydroxyphenyl)-6-(2-methoxyphenyl)-2-((methylamino)methyl)-1,2,3,4-tetrahydronaphthalen-1-ol analogues as highly selective DOR ligands

In vitro SAR and mechanism studies of 1-(3-hydroxyphenyl)-6-...

引用

第11届世界华人药物化学研讨会（iscmc 2018）

作者： Huoming Huang Chen Zhu Xuejun Xu Yujun Wang Jinggen Liu Wei Fu Department of Medicinal Chemistry School of PharmacyFudan University Shanghai Institute of Materia Medica Chinese Academy of Sciences

Opioid receptors,which belong to class A GPCR superfamily,can be classified into four subtypes,i.e.,MOR,DOR,KOR and NOP *** them,DOR was associated with antidepression,antinonciception,*** agonists have the potential for the management of depression,pain,and *** from tramadol,a selective MOR agonist as lead compound,a selective DOR agonist(K_t=2.7±0.6 nM,EC=2.6±0.3 nM,E=205±3%) was *** next explored its SAR and studied its selectivity over MOR and *** SAR campaigns found that removal of o-substution is detrimental for its *** modification at N-substitution caused varied changes in binding *** studies indicated that small side chain of Leu300 at DOR will interacts with3-hydroxyphenyl well,whereas large side chain of Trp318 of MOR and Tyr312 of KOR interacts poorly.

关键词： selective DOR ligands docking studies SAR

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Design,synthesis and biological evaluation of N1-(isoquinolin-5-yl)-N2-phenylpyrrolidine-1,2-dicarboxamide derivatives as potent TRPV1 antagonists

Design,synthesis and biological evaluation of N1-(isoquinoli...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Cunbin Nie Jinyu Li Mingxiang Gao Xinru Cheng Erying Sun Lin Yan School of Pharmacy Henan University

Over the past decade,pharmacological separation of analgesic and hyperthermic effects became the key challenge in developing TRPV1 antagonists as therapeutic agents for pain *** herein is the design,synthesis,and pharmacologic evaluation of a class of TRPV1 antagonists constructed on a N-（isoquinolin-5-yl）-N-phenylpyrrolidine-1,2-dicarboxamide platform that evolved from a 5-aminoisoquinoline urea *** the SAR of this series led to the eventual identification of 3 b,comprising a p-Br substituted *** a TRPV1 functional assay,using cells expressing recombinant human TRPV1 channels,3 b displayed potent antagonism activated by capsaicin(IC = 0.084 μM)and protons(IC = 0.313 μM).In the preliminary analgesic and body temperature tests,3 b exhibited good efficacy in capsaicin-induced and heat-induced pain models and without hyperthermia *** the basis of its superior profiles,3 b could be used as a safe analgesic candidate for pain treatment.

关键词： analgesic transient receptor potential vanilloid type 1 5-aminoisoquinoline urea hyperthermia

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First discovery of 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-ones as HIV-1 ribonuclease H and integrase dual inhibitors

First discovery of 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-ones ...

引用

第11届世界华人药物化学研讨会（iscmc 2018）

作者： Lin Sun Ping Gao Xiqiang Cheng Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong University

The ribonuclease H（RNase H） of the HTV-l reverse transcriptase（RT） represents an attractive but unexploited target for drug design Herein,a series of 5-hydroxypyrido[2,3-b]pyrazin-6(5 H]-one derivatives were designed,synthesized and evaluated biochemically for inhibition against HIV-1 RT RNase H and integrase（IN）,simultaneously,in view of the similarities between the pharmacophore model of RNase H and IN inhibitors as well as their catalytic sites Notably,most compounds inhibited RNase H and IN at micromolar *** them,7 a exhibited similar inhibitory activity against RNase H and IN(IC= 1.77 μM,IC=1.18 μM).To the best of our knowledge,this is the first HTV-1 RNase H-IN dual inhibitor bearing a 5-hydroxypyrido[2,3-6]pyrazin-6（5.H）-one *** optimization is in progress.

关键词： RNase H 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one IN dual inhibitor

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Total synthesis and metabolic stability of hispidulin and its d-Labelled derivative

Total synthesis and metabolic stability of hispidulin and it...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Liangchi Chen Kaicheng Hsu Lihchu Chiou Huiju Tseng Weijan Huang Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Graduate Institute of Brain and Mind Sciences College of MedicineTaiwan University Graduate Institute of Pharmacology College of MedicineTaiwan University Ph.D.Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Hispidulin is a naturally occurring flavone known to have various central nervous system(CNS) *** synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall *** solve these problems,this study developed a novel scheme for synthesizing hispidulin,which had an improved overall yield as well as more concise reaction steps compared to previous methods ***,using the same synthetic strategy,d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver *** work may produce *** entities for enriching the library of hispidulin-derived compounds.

关键词： hispidulin total synthesis flavone microsome stability deuterium-labelled compound

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Discovery of novel benzothiazinone analogs with antitubercular activities

Discovery of novel benzothiazinone analogs with antitubercul...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Gang Zhang Courtney C.,Aldrich State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical Sciences

Decaprenylphosphoryl-D-ribose oxidase（DprE1） is one of the most vulnerable targets in Mycobacterium tuberculosis,which involved in cell wall synthesis by catalyzing the conversion of decaprenylphosphoryl ribose to decaprenylphosphoryl ***,represented by BTZ043 and PBTZ169,is one of the most promising scaffolds with nanomolar concentration against both sensitive-TB and *** representative BTZ043 and PBTZ169 bind covalently with Cys387 in the enzyme active site of DprEl to form a semi-mercaptal enzyme-inhibitor adduct. Despite the exceptional in vitro potency,the corresponding in vivo potency is substantially *** order to improve the ADMET profile,a series of benzothiazinone analogs were synthesized and evaluated against *** H37 *** 10 showed the most potent antitubercular activity with MIC90 values of 16 *** 10 showed good solubility（ADMET solubility of-5.95） than PBTZ169（ADMET solubility of-6.54） predicted by Discovery Studio package 2016,which is suitable for further in vitro and in vivo evaluation.

关键词： DprE1 Benzothiazinone Covalent Inhibitor BTZ043 PBTZ169

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Anti-diabetic effects of linarin,a flavonoid extract from Flos chrysanthemi indici,via AMPK activation

Anti-diabetic effects of linarin,a flavonoid extract from Fl...

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第11届世界华人药物化学研讨会（iscmc2018）

作者： Zhenji Wang Jinghua Yan Jiahui Xu Xiaoqian Meng Yunyu Wang Leyuan Song Yuefeng Bi Zhengzhou University School of Pharmaceutical Science Collaborative Innovation Center of New Drug Research and Safety Evaluation Key Laboratory of Advanced Drug Preparation Technologies(Zhengzhou University Ministry of Education)

Linarin is a natural fiavonoid extract,isolated from Flos chrysanthemi *** show that linarin has a variety of activities such as anticancer,anti-inflammatory and protect hepatic failure *** study aims to investigate the anti-diabetic effect of linarin and the potential *** vitro,linarin can increase the relative glucose consumption of HepG2 cells without affecting the cell viability at concentrations of 10 and 15 μM with dose-effect *** vivo,60 insulin-resistant MSG obese mice were modeled,and random divided into 6 groups:normal group,model group,positive(rosiglitazone) group and 3 linarin groups at the concentrations of 25,50 and 100 mg/*** suspend in tragacanth,administered daily by gavage for four *** tolerance test results show that linarin at 100 mg/kg has certain ameliorate insulin tolerance effect and can continue to reduce *** at 50 mg/kg show a certain degree of glucose tolerance *** at all dosages had no significant influence on body weight of MSG obese *** investigate the anti-diabetic effect mechanism of linarin,we studied its influence on the expression of p-AMPK(AMP-activated protein kinase),and AMP-dependent protein kinases such as p-ACC(acetyl-CoA carboxylase),p-GS(glycogen synthase) and PEPCK(phosphoenolpyruvate carboxykinase) both in vitro and *** results show that insulin can increase the expressions of p-AMPK and p-ACC,and decrease the expressions of PEPCK and *** on the above results,it is speculated that linarin can activate AMPK and then inhibits GS and PEPCK,slow down the progress of ***,it can activate p-ACC,inhibiting the sterol regulator element binding protein(SREBP-1),to reduce fat synthesis.

关键词： linarin anti-diabetic MSG obese mice AMPK

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Design and synthesis of dopamine D3 receptor antagonist

Design and synthesis of dopamine D3 receptor antagonist

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Sui Wang Bin Lin Jiazhen Yin Cheng Niu Hongliang Wen Department of Applied Chemistry School of Chemistry and Chemical EngineeringBeijing Institute of Technology Department of Medicinal Chemistry School of Pharmaceutical EngineeringShenyang Pharmaceutical University

Dopamine is a monoamine neurotransmitter and its receptors are distributed throughout the body,both in CNS and in the *** signaling is mediated through two types of receptors termed D-like（D,D） and D-like（D,D,D） *** lines of evidence indicate that Da receptors play an important role in the pathophysiology of drug addiction and schizophrenia. Ever since dopamine D3 receptor was cloned by Sokoloff et al in 1990, much progress has been made in this area,especially the crystallographical structure of the dopamine D3 receptor was solved by Steven's group. Based on the detailed analyses on the 3 D characteristics of the solved structure and the structure-activity relationship on the existing D3 receptor antagonists,a new series of 1,2,4-triazolyl dopamine D3 receptor antagonist ligands were designed,synthesized and evaluated for their biological *** binding modes of action for these compounds were studied in detail via molecular docking and pharmacophore modeling.

关键词： Dopamine DA D3 receptor Antagonist 1,2,4-Triazol molecular docking

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