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检索条件"任意字段=第11届世界华人药物化学研讨会(ISCMC2018)"
414 条 记 录,以下是41-50 订阅
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Chemical approaches to challenging drug delivery problems:from gasotransmitters to antibody-drug conjugates
Chemical approaches to challenging drug delivery problems:fr...
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11世界华人药物化学研讨会iscmc 2018
作者: Binghe Wang Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State University
Prodrug approaches are often used to solve drug delivery *** doing so,the chemistry needed to bioreversibly derivatize the drug molecule is the *** this line,bioreversible derivatization of gasotransmitters such as ni... 详细信息
来源: 评论
Discovery of novel guinazoline-derived JAK inhibitors
Discovery of novel guinazoline-derived JAK inhibitors
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11世界华人药物化学研讨会iscmc 2018
作者: Xu Bai The Center for Combinatorial Chemistry and Drug Discovery The School of Pharmaceutical SciencesJilin University
The first-generation JAK inhibitors Tofacitinib and Ruxolitinib are considered as promising therapeutics for the treatment of RA or ***,their side effects such as anemia limited their use possibly due to low selectivi... 详细信息
来源: 评论
Rapid advances of nonsmall cell lung cancer treatment:perspectives from 2018
Rapid advances of nonsmall cell lung cancer treatment:perspe...
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11世界华人药物化学研讨会iscmc 2018
作者: James Chihhsin Yang Graduate Institute of Oncology Taiwan University College of Medicine Department of OncologyTaiwan University
Most lung cancer patients were diagnosed at advanced stage,therefore,local treatment for cure is often *** treatment is the mainstay for advanced stage nonsmall cell lung cancer ***-based chemotherapy has become stand... 详细信息
来源: 评论
Gossypol schiff bases with hydrophobic effects providing enhanced anti-tumor activities
Gossypol schiff bases with hydrophobic effects providing enh...
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11世界华人药物化学研讨会iscmc 2018
作者: Wei Wang Yuzhi Lu Haibing Zhou Wuhan University School of Pharmaceutical Sciences
A series of novel gossypol Schiff bases were identified much potent(10-100 fold) than the gossypol and its known Schiff base derivatives for the anticancer activity.[1]This is the first example for Gossypol Schiff bas... 详细信息
来源: 评论
A fluorescent HDAC6 Selective inhibitor capable of imaging aggresome
A fluorescent HDAC6 Selective inhibitor capable of imaging a...
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第11届世界华人药物化学研讨会(iscmc2018)
作者: Yingjie Zhang Jin Yan Tsopang Yao Department of Medicinal Chemistry School of Pharmaceutical of ScienceShandong University Department of Pharmacology and Cancer Biology Duke University
There is increasing interest in discovering HDAC6 selective inhibitors as chemical probes to elucidate the biological functions of HDAC6 and ultimately as new therapeutic ***-molecular fluorescent probes are widely us... 详细信息
来源: 评论
Synthesis and biological evaluation of chromone derivatives
Synthesis and biological evaluation of chromone derivatives
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11世界华人药物化学研讨会iscmc 2018
作者: Runwei Jiao Dahong Li Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Educationand School of Traditional Chinese Materia MedicaShenyang Pharmaceutical University
Chromones,which universally exist in nature,exhibit various pharmacological activities,such as antitumor,anti-inflammatory,antioxidant,cardioprotective,anti-HIV and antimicrobial *** were also favored due to low mamma... 详细信息
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Function-oriented synthesis of phosphatidylserine targeting drug conjugate via click chemistry
Function-oriented synthesis of phosphatidylserine targeting ...
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11世界华人药物化学研讨会iscmc 2018
作者: Kuanhsun Huang Chiayu Hsu Taiyu Chiu Yuwei Liu Yunyu Chen Tengkuang Yeh Jiingjyh Jan Yuchen Huang Chenlung Huang Mingyu Fang Tsuan Hsu Chiungtong Chen Lun K.Tsou Institute of Biotechnology and Pharmaceutical Health Research Institute
Spurred by the encouraging clinical treatment of cancers with antibody drug conjugates(ADC),an emerging strategy with the use of small molecule drug conjugates(SMDC)manifests several advantageous properties,such as be... 详细信息
来源: 评论
Synthesis and anticoagulation studies of fucosylated chondroitin sulfate oligosaccharides
Synthesis and anticoagulation studies of fucosylated chondro...
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第11届世界华人药物化学研讨会(iscmc2018)
作者: Xiao Zhang Huiying Liu Wang Yao Mingyi Wu Zhongjun Li State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical BiologySchool of Pharmaceutical SciencesPeking University State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences
Thrombotic disease is one of the most serious threats to human ***,available antithrombotic drugs have a common side effect:the risk of bleeding during *** show that selective inhibition of the intrinsic coagulation p... 详细信息
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Boron-containing compounds in drug discovery and chemical biology
Boron-containing compounds in drug discovery and chemical bi...
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11世界华人药物化学研讨会iscmc 2018
作者: Jiong Zhang Jinyi Zhang Long Ye Dazhong Ding Huchen Zhou School of Pharmacy Shanghai Jiao Tong University
An interesting class of cyclic boron-containing compounds,benzoxaboroles,were first synthesized in 1957 while its medicinal usage had remained unknown for fifty years until tavaborole(Kerydin) was approved in 2014 f... 详细信息
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Synthesis of glycosidic switch cytotoxic drugs for nanoliposomal delivery to cancer cells
Synthesis of glycosidic switch cytotoxic drugs for nanolipos...
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第11届世界华人药物化学研讨会(iscmc2018)
作者: Pierrealain Burnouf Yulin Leu Yucheng Su Kenneth Wu Weichi Lin Steve Roffler Department of Pharmacy Chia Nan University of Pharmacy & Science
Liposomes provide stable encapsulation and local tumor-specific release for cancer therapy based on enhanced permeability and retention effects to increase therapy outcome and reduce side effect of antitumor ***,the e... 详细信息
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