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检索条件"任意字段=第11届世界华人药物化学研讨会（ISCMC2018）"

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Regioselective synthesis of pyranone-fused indazoles via reductive cyclization and alkyne insertion

Regioselective synthesis of pyranone-fused indazoles via red...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Tzyi Wu Sandip Dhole Manikandan Selvaraju Chungming Sun Department of Applied Chemistry Chiao-Tung University Department of Medicinal and Applied Chemistry Kaohsiung Medical University

A novel and efficient method for the one-pot synthesis of 2 H-indazole from readily available building blocks is *** reaction of 2-nitrobenzylamines with zinc and ammonium formate underwent partial reduction to nitroso benzylamine followed by an intramolecular cyclization to afford 2 H-indazole via N-N bond *** carboxylic acid moiety of indazole was proceeded to regioselective alkyne insertion under ruthenium catalysis to form pyranone-fused *** regioselectivity is influenced by the weak co-ordination of indazole ring nitrogen to the metal center.

关键词： Indazole Reductive cyclization Ru-catalyst Acid-alkyne insertion

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Design,synthhesis,biological and physicochemical evaluation of selective S1P1 agonists

Design,synthhesis,biological and physicochemical evaluation ...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Xiaojian Wang Yonghui Chen Tianqi Liu Qiumu Xi Wenqaing Jia Dali Yin Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences

The Spingosine-1-phosphate receptor 1(S1P1) has been proven to be a potential target for autoimmune ***720 the represented 2-aminopropane-1,3-diol agent has been approved for the treatment of relapsing remitting multiple sclerosis(MS).The clinical efficacy of FTY720 and the understanding of what cause its side effects have initiate intensive efforts toward the discovery of

关键词： Design,synthhesis,biological and physicochemical evaluation of selective S1P1 agonists

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Exploration of farnesoid X receptor ligands based on a library of oleanolic acid A-and C-ring modifications

Exploration of farnesoid X receptor ligands based on a libra...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Weishuo Fang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College

The pentacyclic triterpene oleanolic acid(OA) with known famesoid X receptor(FXR)modulatory activity was modified at A-ring(C-3) and C-ring(C-12) positions to find new FXR-interacting *** agonist-and antagonist-based ligand-FXR binding models were established to assist the design of structural modifications at both sites on A-and *** potent antagonists were found,in addition to a few weak to moderate agonists and compounds with coactivation effects with CDCA,the internal FXR agonist in luciferase-based cell *** vivo PD and PK assessment are in progress.

关键词： farnesoid X receptor FXR triterpene oleanolic acid

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Synthesis of glycosidic switch cytotoxic drugs for nanoliposomal delivery to cancer cells

Synthesis of glycosidic switch cytotoxic drugs for nanolipos...

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第11届世界华人药物化学研讨会（iscmc2018）

作者： Pierrealain Burnouf Yulin Leu Yucheng Su Kenneth Wu Weichi Lin Steve Roffler Department of Pharmacy Chia Nan University of Pharmacy ＆ Science

Liposomes provide stable encapsulation and local tumor-specific release for cancer therapy based on enhanced permeability and retention effects to increase therapy outcome and reduce side effect of antitumor ***,the encapsulation efficiency and stable retention of drugs in liposomes is drug dependent Many potent antitumor drags are difficult to encapsulate and retain in liposomes,thus causing side effect and decreasing the dose of drugs at tumor ***,we propose a glycosidic switch technology to adjust lipid/water solubility of drugs to increase drug loading and stability within *** strategy is to conjugate drugs with a methyl glucuronide via a self—immolative linker to generate a lipid soluble methyl drug glucoronate（Drug-GL） that can directly pass through the lipid bilayer of *** Drug-GL then is converted to water-soluble drug glucuronide（Drug-Gw） via spontaneous saponification within liposomes that increase drug retention and *** extend this concept to create highly potent anticancer agents,we synthesis of the glycosidic switch analog of *** is suitable for an extensive range of drugs and provides a new method to improve the loading and retention of drugs in liposome to increase accumulation of anticancer drugs at target cancer cells and produce greater cytotoxicity for improved therapeutic outcome.

关键词： Liposomes glucuronide

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Discovery of novel 2-amino-pyridine derivatives as potent FGFR/KDR dual inhibitors

Discovery of novel 2-amino-pyridine derivatives as potent FG...

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第11届世界华人药物化学研讨会（iscmc2018）

作者： Li Xing Xia Peng Manman Wei Yang Dai Meiyu Geng Ao Zhang Jing Ai Zilan Song CAS Key Laboratory of Receptor Research and the State Key Laboratory for Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences Division of Anti-tumor Pharmacology State Key Laboratory for Drug ResearchShanghai Institute of Materia Medica(SIMM)Chinese Academy of Sciences

VEGF and FGF are major players of tumor angiogenesis and the synergistic effects of FGF and VEGF have been reported in preclinical studies1’*** on this,stating from the molecular docking study of FGFR1 with phase II clinical FGFR inhibitor Lucitanib,a series of novel 2-amino-pyridine derivatives was designed by quinolone ring-opening coupled with introducing flexible chain from *** 55-2 exhibited equally high potency against FGFR 1/2 and KDR with IC less than 5 *** antiproliferative effects against FGFR 1/2 and KDR addictive cancer cells were ***,compound 55-2 showed significant inhibition of tumor growth in a SNU-16 nude mouse xenograft model with14.9%oral *** work may provide a promising basis for the discovery of clinical agents that target FGFR and KDR.

关键词： FGFR KDR inhibitors 2-amino-pyridine derivatives

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Cyclization strategy in medicinal chemistry:a way to discovery of potent and selective BTK inhibitors

Cyclization strategy in medicinal chemistry:a way to discove...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Yu Xue Zilan Song Ao Zhang CAS Key Laboratory of Receptor Research and the State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences College of Pharmacy University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University

Rational structural optimization is a key to tailor the druglike properties of a lead compound and come up with a well-balanced developable candidate.A good draggable chemotype is generally surrounded by a larger number of patents,therefore a unique approach is necessary to avoid the reported intellectual property and gain a new patentable *** have used a cyclization strategy to form new ring systems either from the core templates or from the

关键词： BTK Cyclization strategy in medicinal chemistry:a way to discovery of potent and selective BTK inhibitors

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Synthesis,cytotoxicity and mechanism of biological action of aza-crown ether-squaramide conjugates as anion/cation symporters

Synthesis,cytotoxicity and mechanism of biological action of...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Xiaoqiao Hong Xiongjie Cai Xihui Yu Wenhua Chen School of Pharmaceutical Sciences Southern Medical University

It is reported that transmembrane anion/cation symport can induce cell death by disrupting the ionic homeostasis of cells. Herein,we designed and synthesized aza-crown ether-squaramide conjugates and studied their anion/cation symport properties and anti-tumor activity（Fig.1）.The results indicate that these conjugates exhibit potent liposomal and in vitro anion/cation symport,and are able to trigger cell apoptosis by modifying the intracellular pH,inducing the basification of acidic organelles in live cells and facilitating the influx of chloride and sodium ions into cells.

关键词： anion/cation symport aza-crown ether squaramide anion transport apoptosis

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Withanolides from Physalis genus and their biological activities

Withanolides from Physalis genus and their biological activi...

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第11届世界华人药物化学研讨会（iscmc2018）

作者： Lixia Chen Wuya College of Innovation Key Laboratory of Structure-Based Drug Design ＆ DiscoveryMinistry of EducationShenyang Pharmaceutical University

The plants of Physcdis genus are distributed widely in the temperate and tropical zones of *** are 5 species and 2 varieties in China,including *** L.,*** ***,*** L.,*** L.,*** *** Bonati,*** L.,*** ***,a group of naturally occurring C-28 steroids based on an ergostane skeleton in which C-26 and C-22,or C-26 and C-23 are appropriately oxidized in order to form a δ-or γ-lactone,are reported as characteristic constituents of Physalis *** type of steroid has attracted significant attention of numerous researchers not only because of their complex structural features,but also their multiple bioactivities and potential in drug research and development,such as their diverse antitumor,antifeedant,antistress,cytotoxic,immunosuppressive,antimicrobial,and anti-inflammatory *** chemical constituents of 4 species from this genus widely distributed in China were investigated by our group,which led to the isolation of 210 withanolides by means of chromatography *** structures were elucidated on the basis of chemical evidences and spectral *** them,a total of 106 are new *** isolated withanolides displayed potential antitumor *** further research on the mechanism of the active withanolides was also carried out by our *** a result,three withanolides were found as antitumor candidates,which could target at novel tumor energy metabolism targets like HIF2α or KGA to induce tumor cell apoptosis.

关键词： Physalis genus withanolides antitumor targets

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A photochemical avenue to photoluminescent N-dots and their upconversion cell imaging

A photochemical avenue to photoluminescent N-dots and their ...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Qingqing Jin Amu Gubu Xiuxian Chen Xinjing Tang State Key Laboratory of Natural and Biomimetic Drugs the School of Pharmaceutical SciencesPeking University

A photochemical avenue to synthesize nitrogen-rich quantum dots（N-dots） using 2-azido imidazole as the starting material was established for the first time[1,2].A production yield of up to 92.7%was *** N-dots were then fully characterized by elemental analysis,IR,XPS,XRD,AFM and *** the basis of the N production and in situ IR results,the underlying mechanism for the photochemical formation of N-dots was *** N-dots showed promising optical properties including wavelength-dependent upconversion photoluminescence,and were successfully used in upconversion cell imaging[3].

关键词： bioimaging upconversion photoluminescence quantum dots N-dots

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Preparation of crystal polymorphs of tetracaine hydrochloride

Preparation of crystal polymorphs of tetracaine hydrochlorid...

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第11届世界华人药物化学研讨会（iscmc 2018）

作者： Shasha Li Shanshan Guo Jie Zhao Yuanmin Din Wen Li School of Chemical Engingeering and Energy Zhengzhou University School of Pharmaceutical Sciences Zhengzhou University Key Laboratory of Technology of Drug Preparation(Zhengzhou University) Ministry of EducationCollaborative Innovation Center of New Drug Research and Safety EvaluationHenan Province& Key Laboratory of Henan Province for Drug Quality and Evaluation

Tetracaine hydrochloride(Fig.1) is a local anesthetic drug widely used in epidural blocks,subarachnoid blocks,nerve conduction blocks,and mucosal surface anesthesia.11"21Through experimentation,we found mat tetracaine hydrochloride could exist in three forms at ambient temperature,denoted forms *** I is the commercial crystal form with a melting point range of 413.15-423.15 *** II was obtained by reciystallization from form I in

关键词： Preparation of crystal polymorphs of tetracaine hydrochloride

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