Tuberculosis (TB) remains a serious threat to global public health, largely due to the successful manipulation of the host immunity by its etiological agent Mycobacterium ***_PGRS protein family of *** might be a cont...
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Tuberculosis (TB) remains a serious threat to global public health, largely due to the successful manipulation of the host immunity by its etiological agent Mycobacterium ***_PGRS protein family of *** might be a contributing *** investigate the roles of PE_PGRS17, the gene of PE_PGRS 17 was expressed in non-pathogenic fast growing *** found that the recombinant strain survives better than the control in macrophage cultures, accompanied by more host cell death and marked higher secretion of TNF-alpha by recombinant strain compared with *** the action of Erk kinase by inhibitor can abolish above *** brief, our data showed that PE_PGRS 17 might facilitate pathogen survival and disserve the host cell via remodeling the macrophages immune niche largely consisting of inflammatory *** furnishes novel insight into the immune role of this Mycobacterium unique gene family.
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