To investigate clinical characteristics and related factors of telbivudine-associated rhabdomyolysis (RM), we searched domestic and foreign medical literature databases as well as Beijing Adverse Drug Reaction Monitor...
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To investigate clinical characteristics and related factors of telbivudine-associated rhabdomyolysis (RM), we searched domestic and foreign medical literature databases as well as Beijing Adverse Drug Reaction Monitoring *** of telbivudine-associated RM were *** information of patients and situations of medications were *** of adverse drug reactions (ADRs), clinical manifestations, treatments and outcomes were investigated and *** reviewing 226 literatures and 41 reports, a total of 22 RM cases were *** the cases were male patients with an average age of 34.5±11.2 years, and all these patients had chronic hepatitis B and received telbivudine 600 mg/*** occurrence time of RM *** case occurred within 5 months (4.5%), 11 cases occurred within 6 to 10 months (50.0%), eight cases occurred within 11 to 15 months (31.8%), and three cases occurred after 15 months (13.6%).Clinical manifestations were mostly nausea, vomiting, palpitations,weakness and edema of the lower *** the telbivudine treatment was discontinued and symptomatic treatments were provided, 12 patients were clinically improved, four patients were physically impaired, two patients showed unknow results, and four deaths were ***, age (P =0.61), duration of medication (P =0.54) and CK value (P =0.07) were not statistically associated with *** are advised to monitor clinical manifestations in patients receiving *** on serum creatinine level is suggested if *** should be promptly discontinued, and symptomatic treatment should be given when ADRs occur.
Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial *** previous study found that CLP-19, a looped peptide derived from limulus anti-lipopolysacchari...
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Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial *** previous study found that CLP-19, a looped peptide derived from limulus anti-lipopolysaccharide peptide with high LPS-neutralizing activity,have showed immunoregulatory effect but the molecular mechanism is *** this study, Our results shows that CLP-19 significantly increased the survival rate in lethal LPS shock mouse models, decreased the serum TNF-α level and reduced the pathological injury of lung 20 h prior to LPS ***-19 also induced endotoxin tolerance (ET) phenotype in RAW 264.7 cells in vitro in a dose-dependent and time-dependent manner, which attenuated LPS-induced TNF-α and IL-6 secretion and increased anti-inflammatory factor, IL-10 *** by CLP-19,the expressions of Toll-like receptors 4 (TLR4) on the cell surface remarkably decreased by LPS ***, CLP-19 pretreatment inhibited degradation of inhibitor of nuclear factor (NF)-κB (I-κB) rather than influenced expression of myeloid differentation 88 (MyD88) and TIR domain-containing adapter inducing IFNγ 6 (TRIF6), resulting in decreased expression of inflammatory cytokine *** together with the finding suggested that CLP-19 induces ET phenotype via inhibiting NF-κB *** conclusion, we have revealed a novel function of CLP-19 that appears to represent a potential therapeutic agent for clinical treatment of sepsis.
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