Purpose:The purpose of this study was to comprehensively compare the 3-dimensional(3D)magnetic resonance imaging(MRI)-guided intracavitary brachytherapy(BT)and conventional 2-dimensional(2D)point A-based intracavitary...
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Purpose:The purpose of this study was to comprehensively compare the 3-dimensional(3D)magnetic resonance imaging(MRI)-guided intracavitary brachytherapy(BT)and conventional 2-dimensional(2D)point A-based intracavitary BT planning for cervical cancer with regard to target coverage and doses to adjacent organs-at risk(OARs).Methods:A total of 79 consecutive patients with cervical cancer were first treated with 2D point A-based external beam radiation therapy,and then with high-dose-rate(HDR)BT between October 2011 and April 2013 at the First Hospital Affiliated to Xi'an Jiao Tong University,Xi'an,*** 2D and 3D treatment planning were compared the difference of the target coverage and doses to bladder,rectum and sigmoid ***:In small tumors,3D BT planning resulted in significantly higher doses to target but lower doses to OARs compared with 2D planning(P<0.05).In big and eccentric tumors,doses to tumor target and OARs in 3D planning were all significantly higher than in 2D planning(P<0.05).However,for the eccentric small tumors,volume doses to OARs in 3D planning were significantly lower than in 2D planning(P<0.05).For bladder and ureter tissues invaded by tumors,the doses to target in 3D planning were significantly higher than in 2D planning(P<0.05).In 3D planning,the doses to adjacent rectum and bladder were significantly higher but those to sigmoid colon were lower than in 2D planning(P<0.05).Conclusions:3D MRI image-guided BT planning increases the dose coverage of target and reduces the HDR-BT-induced toxicity to OARs.
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