Objective:To investigate the change of voltage-dependent calcium channels（VDCCs）current in smooth muscle cells（SMCS）of basilar artery（BA）in a rabbit of subarachnoid hemorrhage（SAH）***:New Zealand White rabbits...
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Objective:To investigate the change of voltage-dependent calcium channels（VDCCs）current in smooth muscle cells（SMCS）of basilar artery（BA）in a rabbit of subarachnoid hemorrhage（SAH）***:New Zealand White rabbits were randomly divided into sham group,normal group,24hours,48 hours and 72 hours after SAH.1ml/kgnonheparinized autologous arterial blood were injected into the cisterna magna in group S1-S3 after intravenous anesthesia and1ml/kg saline at 37℃was injected into cisterna magna in group C *** in group N were done *** artery in S1,S2,S3 group were isolated at 24,48,72 hours after *** artery in C group were isolated at 72 hours after physiological saline injected into cisterna *** basilar artery in N group were isolated *** artery smooth muscle cells in every group were isolated and ***-cell patch-clamp technique was applied to record cell membrane capacitance and VDCCs *** VDCCs antagonists（nifedipine）were added to bath solution and studied the antagonists'inhibition effect on Ca++channels currents in every ***:There were no significant differences in number of cell,cell size and membrane capacitance（P>0.05）in every *** of VDCCs in group S13 had a bigger amplitude than that in group C and N（P<0.05）.The current amplitude in group S3 was bigger than that in group S1 and S2（P<0.05）.There were no significant different Currents of VDCCs between group C and N（P>0.05）.Conclusions:It was increased for the Currents of voltage-dependent Calcium channels in smooth muscle cells of basilar artery after SAH*especially at 72 hours after SAH.
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