The PreS1 of hepatitis B virus(HBV)is located at the outermost part of the envelope protein and possesses several functionally important regions such as hepatocyte receptor-binding site and virus-neutralizing *** pres...
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The PreS1 of hepatitis B virus(HBV)is located at the outermost part of the envelope protein and possesses several functionally important regions such as hepatocyte receptor-binding site and virus-neutralizing *** presence of PreS1 proteins in serum and liver of HBsAg-positive patients has been considered as new markers for HBV infection,indicating viral replication and infectious *** PreS1 antigen(PreS1Ag),detected by time-resolved fluoroimmunoassay(TRFIA)utilizing specific monoclonal anti-PreS1 antibody,is a reliable marker for monitoring residual HBV replication in chronically infected patients receiving or not receiving antiviral *** paper described the establishment and application of the quantitative detection of HBV PreS1Ag in serum using *** parameters such as normal reference range,sensitivity,specificity,precision and recovery rate indicated that the developed TRFIA for PreS1Ag constituted an advanced tool to surpass *** practical terms PreS1 Ag-TRFIA appeared to provide higher sensitivity and broader detection range for PreS1Ag quantification in serum than the commercially available ELISA.
AIM:To evaluate the performance of Hepatitis C Virus(HCV)core antigen and HCV RNA PCR in the determination of the efficacy of HCV antiviral therapy in patients infected with ***:HCV core antigen and HCV RNA were measu...
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AIM:To evaluate the performance of Hepatitis C Virus(HCV)core antigen and HCV RNA PCR in the determination of the efficacy of HCV antiviral therapy in patients infected with ***:HCV core antigen and HCV RNA were measured in sera of 35 chronic HCV infectedChinese *** of HCV core antigen and HCV RNA were analyzed at 5 time points before,during and at the end of antiviral ***:This study showed that the HCV core antigen and HCV RNA concentrations in 35 HCV patientswere significantly *** of HCV core antigen and HCV RNA concentrations at 4th,12th,24th and 48th week were observed during the antiviral ***,HCV core antigen levels at week 12 and24 of therapy was significantly lower than those at week 4(P<0.05).In contrast,no further decrease wasobserved in HCV RNA concentrations during st week 12 and 24(P>0.05).HCV core antigen testing may beadvantageous in some cases,especially if the low levels of HCV core antigen at week 4 are predictive of satisfactory outcome of ***:HCV core antigen represents a stable and sensitive marker of viral replication and could be used to monitor the clinical efficacy of HCV antiviral *** drawn from 35 patients with HCV infection before therapy and at week 4,12,24 and week 48 after antiviral *** assessed the utility of HCV core antigen measurements for assessing the virological response to treatment in Chinese patients.
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