Traditional e-Commerce is in transition to Collaborative one gradually. In the structure of Collaborative e-Commerce, awareness is the key for users to learn all sorts of information about people and system in this en...
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Traditional e-Commerce is in transition to Collaborative one gradually. In the structure of Collaborative e-Commerce, awareness is the key for users to learn all sorts of information about people and system in this environment, which is also an important factor being considered in the process to materialize such a Collaborative e-Commerce environment. this paper presents the analysis of traits of awareness information in Collaborative e-Commerce environment, its forming process and potential problems. A developing platform, which can support the operation of Collaborative e-Commerce using Java JMS technology, also is provided in this paper.
In the event of an emergency evacuation, the total time taken to reach the main exit happens critical and important. the time taken reflected the barriers such as blockages and queuing process. Although the Uniform Bu...
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In this paper, a high linearity CMOS configuration for differential difference current conveyor (DDCC) is presented which is made up of high linearity input and output stages. design tradeoffs are examined and compute...
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In this paper, a high linearity CMOS configuration for differential difference current conveyor (DDCC) is presented which is made up of high linearity input and output stages. design tradeoffs are examined and computer simulation results using PSPICE are used to verify predictions.
Pair programming is a programming practice in which two programmers use one computer to work together on the same analysis, design, and programming of the same software. Collaborative Pair Programming (CPP) supports t...
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Pair programming is a programming practice in which two programmers use one computer to work together on the same analysis, design, and programming of the same software. Collaborative Pair Programming (CPP) supports two programmers to work on the same task from different locations. this paper first reviews the existing CPP tools. then a conversation model during CPP process is presented based on language/action perspective. Some basic requirements of CPP tool are given in terms of the conversation model. Finally, a framework of CPP tool is presented. the framework allows not only to use the same editor between the pairs, but also to support different editors or developing environments between them.
the delegating computation has become an irreversible trend, together comes the pressing need for fairness and efficiency issues. To solve this problem, we leverage game theory to propose a smart c...
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Background: computer-aided drug design has a long history of being applied to discover new molecules to treat various cancers, but it has always been focused on single targets. the development of systems biology has l...
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Background: computer-aided drug design has a long history of being applied to discover new molecules to treat various cancers, but it has always been focused on single targets. the development of systems biology has let scientists reveal more hidden mechanisms of cancers, but attempts to apply systems biology to cancer therapies remain at preliminary stages. Our lab has successfully developed various systems biology models for several cancers. Based on these achievements, we present the first attempt to combine multiple-target therapy with systems biology. Methods: In our previous study, we identified 28 significant proteins-i.e., common core network markers-of four types of cancers as house-keeping proteins of these cancers. In this study, we ranked these proteins by summing their carcinogenesis relevance values (CRVs) across the four cancers, and then performed docking and pharmacophore modeling to do virtual screening on the NCI database for anti-cancer drugs. We also performed pathway analysis on these proteins using Panther and MetaCore to reveal more mechanisms of these cancer house-keeping proteins. Results: We designed several approaches to discover targets for multiple-target cocktail therapies. In the first one, we identified the top 20 drugs for each of the 28 cancer house-keeping proteins, and analyzed the docking pose to further understand the interaction mechanisms of these drugs. After screening for duplicates, we found that 13 of these drugs could target 11 proteins simultaneously. In the second approach, we chose the top 5 proteins withthe highest summed CRVs and used them as the drug targets. We built a pharmacophore and applied it to do virtual screening against the Life-Chemical library for anti-cancer drugs. Based on these results, wet-lab bio-scientists could freely investigate combinations of these drugs for multiple-target therapy for cancers, in contrast to the traditional single target therapy. Conclusions: Combination of systems biology w
In the context of an industrial project we are implementing the software of a casino slot machine. this software has a significant amount of cross-cutting concerns that depend on, and interact with each other, as well...
We explore the task of intrinsic source attribution: inferring which portions of a derived document were adapted from an unobserved source document. Specifically, we model the relationship between news articles and th...
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the technology employed in designing and constructing the FFTF reactor, can significantly influence the development of new advanced reactor designs in the areas of plant system and component design, component fabricat...
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In design Science Research (DSR) it is important to build on descriptive (Omega) and prescriptive (Lambda) state-of-the-art knowledge in order to provide a solid grounding. However, existing knowledge is typically mad...
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ISBN:
(纸本)9783030195038;9783030195045
In design Science Research (DSR) it is important to build on descriptive (Omega) and prescriptive (Lambda) state-of-the-art knowledge in order to provide a solid grounding. However, existing knowledge is typically made available via scientific publications. this leads to two challenges: first, scholars have to manually extract relevant knowledge pieces from the data-wise unstructured textual nature of scientific publications. Second, different research results can interact and exclude each other, which makes an aggregation, combination, and application of extracted knowledge pieces quite complex. In this paper, we present how we addressed both issues in a DSR project that focuses on the design of socially-adaptive chatbots. therefore, we outline a twostep approach to transform phenomena and relationships described in the Omega-knowledge base in a machine-executable form using ontologies and a knowledge base. Following this new approach, we can design a system that is able to aggregate and combine existing Omega-knowledge in the field of chatbots. Hence, our work contributes to DSR methodology by suggesting a new approach for theory-guided DSR projects that facilitates the application and sharing of state-of-the-art Omega-knowledge.
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