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检索条件"任意字段=18th International Conference on DNA Computing and Molecular Programming, DNA 18"

共 121 条记录，以下是11-20 订阅

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CONNECTABLE dna-LOGIC OPERATION USING DROPLETS AND RUPTURE/REFORMATION OF BILAYER LIPID MEMBRANES 18

CONNECTABLE DNA-LOGIC OPERATION USING DROPLETS AND RUPTURE/R...

引用

18th international conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

作者： Inoue, K. Kawano, R. Yasuga, H. Takinoue, M. Osaki, T. Kamiya, K. Miki, N. Takeuchi, S. Keio Univ Tokyo Japan Kanagawa Acad Sci & Technol Kawasaki Kanagawa Japan Tokyo Univ Agr & Technol Tokyo Japan Tokyo Inst Technol Tokyo Japan Univ Tokyo Inst Ind & Technol Tokyo Japan

ISBN: (纸本)9781479989553

this paper experimentally demonstrated the connection of logic gates using dna and membrane protein's channel reconstituted into bilayer lipid membranes (BLMs). In this system, droplets worked as the carrier of dna to convey it as biological signal to next stage and reformation and rupture of BLM accelerated dna transfer between droplets. Furthermore, dna is detected based on the electrical and physical characters of dna translocation via membrane protein's channel. In this study, we successfully demonstrated NOR operation by connecting OR and NOT gate. this system is readily applicable to develop high sensitive biosensor and computing system imitating biological information processing.

关键词： Logic gate Membrane protein Planar lipid bilayer hybridization dna computing Single molecule detection

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dna computing Units Based on Fractional Coding 1

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18th international conference on Unconventional Computation and Natural Computation (UCNC)

作者： Salehi, Sayed Ahmad Moore, Peyton Univ Kentucky Lexington KY 40506 USA

ISBN: (数字)9783030193119

ISBN: (纸本)9783030193119;9783030193102

Fractional encoding has been recently proposed as a promising convention to represent information in molecular computing systems. this paper presents new 2-input molecular computing units based on unipolar fractional representation. the units calculate simple computational equations that can be used for the computation of more complex functions. the design of these molecular computing units is inspired by fan-in 2 logic gates in the field of stochastic computing. Each computing unit consists of four chemical reactions with two reactants and one product. We design the dna reactions implementing the chemical reactions of each unit based on the toehold-mediated dna strand-displacement mechanism. Every unit is designed by four input strands and eight fuel gate strands of dna. Since dna molecules related to the input and output of the units have the same form of domain-toehold-domain-toehold, output molecules of each unit can be used as input for other units and this provides the cascading of the units for designing complex circuits. the whole dna pathway for each unit is composed of twenty dna reactions. the simulation results by Visual DSD show that the dna implementations follow the theoretically expected computations of each unit with the maximum of 9.33% error.

关键词： dna computing Fractional coding dna strand-displacement

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Sizing and sorting of single dna molecules by microfluidic molecular combing device 18

Sizing and sorting of single DNA molecules by microfluidic m...

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18th international conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

作者： Onoshima, Daisuke Kawakita, Naoko Takeshita, Daiki Yukawa, Hiroshi Baba, Yoshinobu Instiute of Innovation for Future Society Nagoya University Japan FIRST Research Center for Innovative Nanobiodevices Nagoya University Japan Department of Applied Chemistry Graduate School of Engineering Nagoya University Japan Japan

ISBN: (纸本)9780979806476

We report a microfluidic molecular combing device to trap, stretch, and separate dna at a singlemolecule resolution. In order to align long dna into a single direction on surface, we demonstrated molecular combing by dewetting dna solution inside a microfluidic channel. It used a surface tensional force at the air-water interface of dna solution translating on a fabricated pattern (zigzag line). When the speed of molecular translation and adsorption were balanced by pressure control, dna was stretched along the direction of flow. By specifying the location of dna attachment at the zigzag vertices, the device served as a molecular ruler for sizing and sorting of single dna molecules. © 14CBMS.

关键词： dna

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AN ELECTROKINETIC MICRODEVICE FOR ISOLATION AND QUANTIFICATION OF CIRCULATING CELL-FREE dna FROM PHYSIOLOGICAL SAMPLES 18

AN ELECTROKINETIC MICRODEVICE FOR ISOLATION AND QUANTIFICATI...

引用

18th international conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

作者： Lamanda, Ariana Lu, Yi Gill, Navrose Wong, Pak Kin Univ Arizona Biomed Engn Tucson AZ 85721 USA Univ Arizona Aerosp & Mech Engn Tucson AZ USA Univ Arizona Mol & Cellular Biol & Physiol Tucson AZ USA

ISBN: (纸本)9781479989553

this study reports a hybrid electrokinetic microdevice for rapid concentration and detection of circulating cell-free (cf)dna. Rapid molecular analysis of cfdna has the potential to change the current practice of medicine, such as in cancer diagnostics and in monitoring the efficacy of cancer treatments. With a combination of AC electrothermal flow and dielectrophoresis, the hybrid electrokinetic microdevice efficiently concentrates cfdna from blood plasma and other physiological fluids. In this design, the long-range AC electrothermal flow, which is effective in conductive fluids, drives the cfdna towards the center of the electrode where dielectrophoretic trapping of the cfdna occurs. Once the cfdna is collected at the electrode, the concentration in the blood sample can be quantified by fluorescence analysis with an intercalating dye that binds specifically to double-stranded dna. the effects of the electrokinetic parameters were elucidated to optimize the design of the device. the device was demonstrated to separate high molecular weight dna from low molecular weight dna. Quantitative detection of clinically relevant concentrations of cfdna was achieved in 10 minutes.

关键词： AC electrokinetics circulating cell-free dna dielectrophoresis cancer AC electrothermal flow

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18th international conference on Unconventional Computation and Natural Computation, UCNC 2019

18th International Conference on Unconventional Computation ...

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18th international conference on Unconventional Computation and Natural Computation, UCNC 2019

ISBN: (纸本)9783030193102

the proceedings contain 21 papers. the special focus in this conference is on Unconventional Computation and Natural Computation. the topics include: An Exponentially Growing Nubot System Without State Changes;Impossibility of Sufficiently Simple Chemical Reaction Network Implementations in dna Strand Displacement;Quantum Algorithm for Dynamic programming Approach for DAGs. Applications for Zhegalkin Polynomial Evaluation and Some Problems on DAGs;viewing Rate-Based Neurons as Biophysical Conductance Outputting Models;the Lyapunov Exponents of Reversible Cellular Automata Are Uncomputable;geometric Tiles and Powers and Limitations of Geometric Hindrance in Self-assembly;dna computing Units Based on Fractional Coding;the Role of the Representational Entity in Physical computing;OIM: Oscillator-Based Ising Machines for Solving Combinatorial Optimisation Problems;co-Designing the Computational Model and the computing Substrate: (Invited Paper);relativizations of Nonuniform Quantum Finite Automata Families;self-stabilizing Gellular Automata;generalized Membrane Systems with Dynamical Structure, Petri Nets, and Multiset Approximation Spaces;quantum Dual Adversary for Hidden Subgroups and Beyond;further Properties of Self-assembly by Hairpin Formation;the Role of Structure and Complexity on Reservoir computing Quality;lindenmayer Systems and Global Transformations;swarm-Based Multiset Rewriting computing Models;dna Origami Words and Rewriting Systems.

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Synthesizing minimal tile sets for complex patterns in the framework of patterned dna self-assembly

Synthesizing minimal tile sets for complex patterns in the f...

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18th international conference on dna computing and molecular programming, dna 18

作者： Czeizler, Eugen Popa, Alexandru Department of Information and Computer Science School of Science Aalto University Aalto FI-00076 Finland Department of Communications and Networking School of Electrical Engineering Aalto University P.O. Box 15400 Aalto FI-00076 Finland

ISBN: (纸本)9783642322075

Ma and Lombardi (2009) introduce and study the Pattern self-Assembly Tile set Synthesis (PATS) problem. In particular they show that the optimization version of the PATS problem is NP-hard. However, their NP-hardness proof turns out to be incorrect. Our main result is to give a correct NP-hardness proof via a reduction from the 3SAT. By definition, the PATS problem assumes that the assembly of a pattern starts always from an "L"-shaped seed structure, fixing the borders of the pattern. In this context, we study the assembly complexity of various pattern families and we show how to construct families of patterns which require a non-constant number of tiles to be assembled. © 2012 Springer-Verlag.

关键词： Self assembly

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6th international Workshop on dna-Based Computers, dna 2000

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6th international Workshop on dna-Based Computers, dna 2000

ISBN: (纸本)3540420762

the proceedings contain 18 papers. the special focus in this conference is on dna computing. the topics include: Engineered communications for microbial robotics;solution of a satisfiability problem on a gel-based dna computer;Diophantine equations and splicing;a new demonstration of the generative capability of h systems;about time-varying distributed h systems;string tile models for dna computing by self-assembly;from molecular computing to molecular programming;graph replacement chemistry for dna processing;molecular computing with generalized homogeneous p-systems;computationally inspired biotechnologies;improved dna synthesis and associative search using error-correcting codes and vector-quantization;challenges and applications for self-assembled dna nanostructures;a dna-based random walk method for solving k-sat;solving computational learning problems of Boolean formulae on dna computers;the fidelity of annealing-ligation;dna implementation of a royal road fitness evaluation and steady flow micro-reactor module for pipelined dna computations.

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dna self-assembly and computation studied with a coarse-grained dynamic bonded model

DNA self-assembly and computation studied with a coarse-grai...

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18th international conference on dna computing and molecular programming, dna 18

作者： Svaneborg, Carsten Fellermann, Harold Rasmussen, Steen Center for Fundamental Living Technology Department of Physics Chemistry and Pharmacy University of Southern Denmark Campusvej 55 Odense DK-5320 Denmark Complex Systems Lab. Barcelona Biomedical Research Park Universitat Pompeu Fabra Dr. Aiguadé 88 08003 Barcelona Spain Santa Fe Institute 1399 Hyde Park Road Santa Fe NM 87501 United States

ISBN: (纸本)9783642322075

We study dna self-assembly and dna computation using a coarse-grained dna model within the directional dynamic bonding framework [C. Svaneborg, Comp. Phys. Comm. 183, 1793 (2012)]. In our model, a single nucleotide or domain is represented by a single interaction site. Complementary sites can reversibly hybridize and dehybridize during a simulation. this bond dynamics induces a dynamics of the angular and dihedral bonds, that model the collective effects of chemical structure on the hybridization dynamics. We use the dna model to perform simulations of the self-assembly kinetics of dna tetrahedra, an icosahedron, as well as strand displacement operations used in dna computation. © 2012 Springer-Verlag.

关键词： Dynamics

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A dna-based Authentication System for Securing Cloud Data Storage and Transactions 18

A DNA-based Authentication System for Securing Cloud Data St...

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18th INDIAcom;11th international conference on computing for Sustainable Global Development, INDIACom 2024

作者： Kumar, Tarun Kumar, Prabhat Namasudra, Suyel National Institute of Technology Dept. of Computer Sc. & Engineering Patna India National Institute of Technology Dept. of Computer Sc. & Engineering Agartala India

ISBN: (纸本)9789380544519

Cloud computing has grown rapidly, but data breaches and unauthorized account access remain a persistent threat. Commonly used cryptographic authentication methods rely on mathematically complex but computationally insecure protocols. this paper suggests using new developments in deoxyribonucleic acid (dna) computing to make the cloud safer by using biological authentication protocols that can be used by a lot of people. A dna-based cryptographic key system is developed for leveraging synthetic dna's dense information capacity. this approach interfaces biochemically secure dna signatures with existing cloud architectures to provide multi-factor authentication (MFA), encrypting access to sensitive user data and transactions. the developed dna cryptography protocols offer resilience against common attacks like password leaks, while the massive parallelism inherent in biochemical reactions allows efficient processing of authentication requests even under immense cloud workloads. this paper proposes the system's security using established threat frameworks, analyzing attack vectors related to storage, access control, data leakage, etc. this interdisciplinary approach highlights how dna computing's advantages in encryption, steganography, and blockchain can address real-world cybersecurity needs. © 2024 Bharati Vidyapeeth, New Delhi.

关键词： Biometrics Cloud Data Security dna Cryptography Multi-factor Authentication Synthetic Biology

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A dna based molecular logic gate capable of a variety of logical operations

A DNA based molecular logic gate capable of a variety of log...

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18th international conference on dna computing and molecular programming, dna 18

作者： Kan, Anton Shohda, Koh-Ichiroh Suyama, Akira Department of Life Sciences Institute of Physics University of Tokyo 3-8-1 Komaba Meguro-ku Tokyo 153-8902 Japan

ISBN: (纸本)9783642322075

In this paper we report on a module in the RTRACS molecular computing system, constructed with dna, RNA and enzymes. the module is a 2-input logic gate that receives input and produces output in the form of RNA molecules. Each of the two input molecules is chosen from a set of two, and the logic gate produces an output molecule for each of the four possible input combinations. Two output RNA molecules can be produced by this module, one for only one combination of inputs, whilst the remaining three combinations lead to the production of the other output. Since the RNA strands can be arbitrarily assigned logical values, this module is capable performing multiple logical operations, including AND, NAND, OR and NOR, given the appropriate mapping of RNA molecules to logical values. We performed numerical simulations of the logic gate reaction scheme, revealing the details of the kinetics of the production of output molecules and the theoretical input-output characteristics. We also experimentally demonstrated the proper functioning of the logic gate, showing the correct formation of intermediate steps, the real time production of output molecules as well as the input-output characteristics of the module. We believe this versatile logic gate has significant advantages as a basic module of RTRACS due to the wide variety of possible logical operations. © 2012 Springer-Verlag.

关键词： Logic gates

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