Background Among patients with type 2 diabetes，effects of intensive glucose control on major vascular outcomes remain uncertain． Methods 11140 patients with type 2 diabetes were randomized to intensive glucose ...
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Background Among patients with type 2 diabetes，effects of intensive glucose control on major vascular outcomes remain uncertain．
Methods 11140 patients with type 2 diabetes were randomized to intensive glucose control using gliclazide (modified-release) and other drugs as required to achieve HbA1c≤6.5％，or to standard *** endpoints were composites of major macrovascular (cardiovascular death，non-fatal myocardial infarction，non-fatal stroke) and major microvascular events (new or worsening nephropathy or retinopathy)，assessed jointly and separately．
Conclusions Lowering average HbAlc to 6.5％ reduced the risk of major vascular events primarily due to a reduction in *** hypoglycemic events were uncommon, but were in-creased by intensive control. There were no clear effects on risks of retinopathy, macrovascular events or death. (***, number NCT00145925)
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