Objectives:Our previous study demonstrated that HTPAP is a metastatic suppressor of hepatocellular *** this study,we investigate the possible association of the genetic polymorphisms of HTPAP gene with its function an...
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Objectives:Our previous study demonstrated that HTPAP is a metastatic suppressor of hepatocellular *** this study,we investigate the possible association of the genetic polymorphisms of HTPAP gene with its function and the prognosis of patients with hepatocellular carcinoma.
MicroRNAs(miRNAs) are an evolutionarily conserved class of endogenous non-coding RNAs that modulate gene expression at the post-transcriptional level. MicroRNA-23a(miR-23a) was recently found to function as a growth-p...
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MicroRNAs(miRNAs) are an evolutionarily conserved class of endogenous non-coding RNAs that modulate gene expression at the post-transcriptional level. MicroRNA-23a(miR-23a) was recently found to function as a growth-promoting and
Objectives:To explore the biological role of RPB5-mediating protein(RMP) in the growth and the biological property of hepatoma cell SMMC-7721. Methods:Hepatoma cells SMMC-7721 were cultured in *** overexpression and R...
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Objectives:To explore the biological role of RPB5-mediating protein(RMP) in the growth and the biological property of hepatoma cell SMMC-7721. Methods:Hepatoma cells SMMC-7721 were cultured in *** overexpression and RNA interference were applied to establish stable cell lines of
Kinase genes are considered as vital role playing in cancer conformation,and aberrant expression and mutations are used as target for new drug *** mutations may provide possible diagnostic and therapeutic targets in h...
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Kinase genes are considered as vital role playing in cancer conformation,and aberrant expression and mutations are used as target for new drug *** mutations may provide possible diagnostic and therapeutic targets in human cancer. Recent advances in high-throughput sequencing technologies are providing
Purpose:The roles of THBS-1 in tumor growth and metastasis are complicated. Controversy occurs frequently when confronting whether it is a cancer inhibitor or *** study is to clinically reveal the functional roles of ...
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Purpose:The roles of THBS-1 in tumor growth and metastasis are complicated. Controversy occurs frequently when confronting whether it is a cancer inhibitor or *** study is to clinically reveal the functional roles of THBS-1 in gastric
Objectives:BRD7 is a novel bromodomain gene cloned by cDNA representational differential assay by our *** overexpressed BRD7 could inhibit the proliferation of nasopharyngeal carcinoma(NPC) cells and arrest them in G0...
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Objectives:BRD7 is a novel bromodomain gene cloned by cDNA representational differential assay by our *** overexpressed BRD7 could inhibit the proliferation of nasopharyngeal carcinoma(NPC) cells and arrest them in G0/G1 phase by
CD147 is a transmembrance glycoprotein that promotes tumor progress invasion and *** of CD147 has been observed in various types of human *** changes in cell adhesion and migration during tumour invasion are reminisce...
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CD147 is a transmembrance glycoprotein that promotes tumor progress invasion and *** of CD147 has been observed in various types of human *** changes in cell adhesion and migration during tumour invasion are reminiscent of an important developmental process termed epithelial-mesenchymal
Increasing epidemiological evidence indicated that alterations of mitochodrial DNA (mtDNA),including mtDNA mutation and change of mtDNA content,were clearly invovled in the carcinogenesis of several malignancies in a ...
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Increasing epidemiological evidence indicated that alterations of mitochodrial DNA (mtDNA),including mtDNA mutation and change of mtDNA content,were clearly invovled in the carcinogenesis of several malignancies in a tumor-specific manner,such as lung cancer,breast cancer,and Non-Hodgkin ***,whether mtDNA
Purpose:The meta-analysis was performed to assess the efficacy and toxicities of CPT-11 involved regimens in patients with advanced gastric *** and Methods:Randomized phaseⅡandⅢclinical trials using CPT-11 based che...
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Purpose:The meta-analysis was performed to assess the efficacy and toxicities of CPT-11 involved regimens in patients with advanced gastric *** and Methods:Randomized phaseⅡandⅢclinical trials using CPT-11 based chemotherapy in advanced gastric cancer were
Colorectal cancer(CRC) is the fourth common malignancy and the second leading cause of cancer death in Western *** drugs like cetuximab,an anti-EGFR monoclonal antibody(mAb),have demonstrated some clinical benefits fo...
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Colorectal cancer(CRC) is the fourth common malignancy and the second leading cause of cancer death in Western *** drugs like cetuximab,an anti-EGFR monoclonal antibody(mAb),have demonstrated some clinical benefits for CRC *** the responses are different in individuals,which attributes to
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