Background: Following ingestion, dietary triglycerides (TG) are digested, absorbed, resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled...
Background: Following ingestion, dietary triglycerides (TG) are digested, absorbed, resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipoproteins (LP).
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as...
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as overexpression of ATP-binding cassette transporters (typically, p-glycoproteins, P-gp) and malfunction of ***-penetrating peptide-based strategies were developed for overcoming the barriers against effective cancer drug delivery, through the mechanisms including increased tumor penetration, enhanced intmcellular and intranuclear delivery, prolonged intracellular drug retention, thus yielding promising treatment benefits in the animal models.
Doxorubicin (DOX) is a commonly used chemotherapy drug for treating ***, the severe non-selective toxicity and development of multiple drug resistance (MDR) hinder its clinical ***, it is imperative to develop a novel...
Doxorubicin (DOX) is a commonly used chemotherapy drug for treating ***, the severe non-selective toxicity and development of multiple drug resistance (MDR) hinder its clinical ***, it is imperative to develop a novel drug delivery system, which can not only deliver DOX to tumor sites but also overcome *** addition to nucleus, mitochondria were found to be another sub-cellular targeting of DOX ***, it has been reported that delocalized lipophilic cations (DLCs) can accumulate in the cell mitochondria because of the inner membrane potential of mitochondria.
Aim: To develop a theranostic nanoemulsion (TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB).Materials & methods: The TNE was es...
Aim: To develop a theranostic nanoemulsion (TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB).Materials & methods: The TNE was established using core-matched technology, and can achieve high encapsulation efficiency and synchronized release of the loaded *** has been examined for a correlation between the dynamic uptake of PTX and the intensity of SRB imaging signal in different *** & discussion: Our data denonstrates that the TNE, with improved circulation time, increases therapeutic efficacy and imaging efficiency in both drug-sensitive and drug-resistant *** TNE could not satisfy the demand of visual diagnosis in the living animal because of *** therefore formulated a long-circulating theranostic nanoemulsion (LCTNE).Results showed that the LCTNE can meet imaging requirements in ***: The LCTNE increases therapeutic efficacy and imaging efficiency for both tumor types *** LCTNE plays a good therapeutic and diagnostic role for subcutaneous tumors in the living *** The LCTNE reported here provides insights into the development of new theranostic nanocarriers for the treatment of MDR in cancer.
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