Most of the photosensitizers(PS) investigated and/or being used to date in photodynamic therapy(PDT) are highly *** property has been used to guide surgical interventions and ***, most of the photosensitizers exhibit ...
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Most of the photosensitizers(PS) investigated and/or being used to date in photodynamic therapy(PDT) are highly *** property has been used to guide surgical interventions and ***, most of the photosensitizers exhibit small Stokes shift(s) between the long-wavelength absorption and emission and are therefore not desirable candidates for fluorescence imaging of ***,certain
Polymeric micelles have recently emerged as a novel promising colloidal carrier for the delivery of drugs,proteins and genes, which are composed of amphiphilic macromolecules that have distinct hydrophobic and hydroph...
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Polymeric micelles have recently emerged as a novel promising colloidal carrier for the delivery of drugs,proteins and genes, which are composed of amphiphilic macromolecules that have distinct hydrophobic and hydrophilic block domains,with the structure of the copolymers usually being a di-block,tri-block,or graft *** structure of copolymeric micelles formed by
Objective:A big amount of surfactants were in need to form microemulsions and consequent toxicity restricted the application of *** decrease the amount of surfactants in microemulsion is *** present research showed th...
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Objective:A big amount of surfactants were in need to form microemulsions and consequent toxicity restricted the application of *** decrease the amount of surfactants in microemulsion is *** present research showed that mixing oils could enlarge the domain of microemulsions and reduce the amount of *** it is unknown whether lower amount of surfactants in microemulsions induce lower bioavailability or *** purpose of this research is to study the factors influencing the domain of mixing oils microemulsions and confirm whether lowing amount of surfactants in microemulsions induce lower bioavailability or not.
The study aimed to develop a polyethyleneimine (PEI) derivative (ESP) with ES for gene delivery to improve the transfection efficiency and tumor targeting of PEI as a gene *** ESP was synthesized by a michael addition...
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The study aimed to develop a polyethyleneimine (PEI) derivative (ESP) with ES for gene delivery to improve the transfection efficiency and tumor targeting of PEI as a gene *** ESP was synthesized by a michael addition reaction between double bond of ES and *** ESP/pDNA complexes were prepared,and their characterizations were *** size of complexes was about 150 nm at optimal charge ratio.
Object:In this study paclitaxel nanosuspensions were successfully prepared by using TPGS as the stabilizers,which can inhibit the efflux function of *** pharmacokinetics and acute toxicity were evaluated in ***:The pa...
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Object:In this study paclitaxel nanosuspensions were successfully prepared by using TPGS as the stabilizers,which can inhibit the efflux function of *** pharmacokinetics and acute toxicity were evaluated in ***:The paclitaxel nanosuspensions were prepared by the evaporative precipitation into aqueous solution (EPAS) method,and the freeze-dried powders of the suspensions were obtained through lyophilization process.
OBJECTIVE:Formulation development strategies of poorly soluble drugs are briefly discussed in this *** physical techniques to improve the dissolution of hydrophobic drugs include the use of a drug in its metastable st...
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OBJECTIVE:Formulation development strategies of poorly soluble drugs are briefly discussed in this *** physical techniques to improve the dissolution of hydrophobic drugs include the use of a drug in its metastable state,formation of a solid dispersion,particle size reduction,and use of *** of metastable forms,solid dispersions and solubilizers relies on solubility enhancement whereas particle size reduction increases surface area leading to more rapid ***
Nanotechnology is a new brand of interdisciplinary science which consists of experimental and theoretical studies in various research fields,such as electronics,optics,material and ***,the preparation and application ...
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Nanotechnology is a new brand of interdisciplinary science which consists of experimental and theoretical studies in various research fields,such as electronics,optics,material and ***,the preparation and application of nano-biological materials,***-films,are acknowledged to be effective means for medical field ***,it is a great challenge to fabricate the biological films with patterned structures or ultra-thin thickness because most organic molecules are so fragile that the
Aim:Canosic acid is a phenolic diterpene,which is considered to be the most important antioxidant constituent of Rosemarinus officinalis L and Salvia officinalis *** carnosic acid is almost insoluble in *** absorption...
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Aim:Canosic acid is a phenolic diterpene,which is considered to be the most important antioxidant constituent of Rosemarinus officinalis L and Salvia officinalis *** carnosic acid is almost insoluble in *** absorption of CA is slow after intragastric *** absolute bioavailability of camosic acid is ***,to improve the oral b ioavailability of carnosic acid,the camosic acid self-emulsified delivery system was prepared and evaluated.
OBJECTIVE:The purpose of our study was to comprehensively compare in vivo performances of discoidal and spherical recombinant high density lipoproteins loaded with cardiovascular drug tanshinone IIA (TA-d-rHDL and TA-...
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OBJECTIVE:The purpose of our study was to comprehensively compare in vivo performances of discoidal and spherical recombinant high density lipoproteins loaded with cardiovascular drug tanshinone IIA (TA-d-rHDL and TA-s-rHDL),in order to provide some references for rHDL as cardiovascular drugs delivery systems.
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