Pigmentation,such as chloasma,is a common disorder easy to relapse but difficult to *** purpose of this study is to develop a percutaneous drug delivery system,melanocyte-active targeting nanoparticles based on the mi...
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Pigmentation,such as chloasma,is a common disorder easy to relapse but difficult to *** purpose of this study is to develop a percutaneous drug delivery system,melanocyte-active targeting nanoparticles based on the microneedle,which can overcome the stratum corneum barrier to deliver sufficient drug into the basal layer of the skin,and also can actively target to the melanocyte to inhibit the formation of melanin.
*** evaluate the potentially improved therapeutic efficacy and safety of nephrotropic macromolecular prodrugs of glucocorticoids(GC) in the treatment of lupus nephritis. *** injection of N-(2-hydroxypropyl)methacrylam...
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*** evaluate the potentially improved therapeutic efficacy and safety of nephrotropic macromolecular prodrugs of glucocorticoids(GC) in the treatment of lupus nephritis. *** injection of N-(2-hydroxypropyl)methacrylamide(HPMA) copolymer-based dexamethasone prodrug(P-Dex) and daily injection of dexamethasone phosphate sodium(Dex,overall dose equivalent to P-Dex) were given to lupus-prone(NZBxNZW)Fl female mice for two *** animals
Thymopentin,TP-5,the 32nd to 36th peptide fragments(Arg-Lys-Asp-Val-Tyr) of the 49 amino acid of thymopoietin,is reported to have the same biological activity as the mother *** most common clinical use of TP-5 include...
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Thymopentin,TP-5,the 32nd to 36th peptide fragments(Arg-Lys-Asp-Val-Tyr) of the 49 amino acid of thymopoietin,is reported to have the same biological activity as the mother *** most common clinical use of TP-5 includes the treatment for chronic hepatitis B,chronic hepatitis C,autoimmune diseases,as well as malignant tumors in patients who has depressed immune system due to radiotherapy or ***,the studies on pharmacokinetics and stability both in vitro and in vivo of TP-5 have
Introduction:Cell-penetrating peptides(CPP) that possess ability to transport macromolecules across the cell membrane have been developed as vehicles for intracellular delivery of therapeutic *** so far,a number of CP...
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Introduction:Cell-penetrating peptides(CPP) that possess ability to transport macromolecules across the cell membrane have been developed as vehicles for intracellular delivery of therapeutic *** so far,a number of CPPs were derived from viral or other organism proteins such as TAT,*** CPPs may have antigenicity to human for clinic using ***
Serious toxicity and multidrug resistance are the vital issues which significantly decrease the efficacy of anticancer drugs and cause tumor ***-based drug delivery systems have shown opportunities to overcome tumor r...
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Serious toxicity and multidrug resistance are the vital issues which significantly decrease the efficacy of anticancer drugs and cause tumor ***-based drug delivery systems have shown opportunities to overcome tumor resistance and improve the drug accumulation at the tumor site by combining the EPR effect with the longer systemic circulation properties of PEGylation nanoparticles(NPs).While,the actual percentage of PEGylated NPs accumulating at the tumor site was only a few
Low density lipoprotein(LDL) is formed by the apolipoprotein and lipid *** has the special structure of the hydrophilic shell and lipophilic kernel and is the main carrier for delivery of cholesterol to the tissues,an...
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Low density lipoprotein(LDL) is formed by the apolipoprotein and lipid *** has the special structure of the hydrophilic shell and lipophilic kernel and is the main carrier for delivery of cholesterol to the tissues,and also could be used to deliver lipophilic anticancer drugs to *** have shown that tumor cells proliferation will lead the tumor tissues to require *** the tumor cells will upregulate low density lipoprotein receptors,which provides an opportunity for low density lipoprotein to targeted
It is well known that B-cyclodextrin(B-CD) possesses a remarkable ability to incorporate proper guest molecules into their hydrophobic cavities via noncovalent interactions.(l) Functionalized B-CD has been widely expl...
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It is well known that B-cyclodextrin(B-CD) possesses a remarkable ability to incorporate proper guest molecules into their hydrophobic cavities via noncovalent interactions.(l) Functionalized B-CD has been widely explored as potential drug delivery vehicles for cancer treatment.
Object:Curcumin is widely known for its medicinal properties including its anticancer activity,but its water-insolubility and instability make its bioavailability exceedingly low and thus it was generally inactive in ...
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Object:Curcumin is widely known for its medicinal properties including its anticancer activity,but its water-insolubility and instability make its bioavailability exceedingly low and thus it was generally inactive in vivo anticancer ***,we report a bioreducible nanosize anticancer drug-polycurcumin to overcome above ***:Polycurcumin was synthesized with curcumin and 3,3'-dithiodipropionic acid,the stability of curcumin at physiological pH was monitored by ultraviolet spectrophotometer,the cytotoxicity was studied using MTT,the cellular uptake was observed by confocal microscope,retardation of cell cycle and induction of cell apoptosis by polycurcumin were analyzed by flow cytometry
Objectives:To investigate the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/***:The microdialysis systems...
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Objectives:To investigate the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/***:The microdialysis systems were established by linear probes and concentric circles *** vivo recovery of paeonol in skin is 69.7±4.8% and in blood is 51.6±7.2%.The paeonol microemulsion,microemulsion based gels and marketed paeonol ointments were administrated to *** (pH7.4) served as perfused solution.
Objective:To prepare salmeterol xinafoate(SalX)-loaded nanoparticles-in-microparticles system(NiMS). Methods:SalX loaded nanoparticles was formed through ionotropic gelation process with biocompatible chitosan as the ...
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Objective:To prepare salmeterol xinafoate(SalX)-loaded nanoparticles-in-microparticles system(NiMS). Methods:SalX loaded nanoparticles was formed through ionotropic gelation process with biocompatible chitosan as the carrier *** a one step technique of spray drying was used to microencapsulate the colloidal nanoparticle suspension to form powdered NiMS *** morphology and surface appearance of the spray-dried NiMS were examined by scanning electron
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