The present work explored the possibility of formulating oral insulin delivery system by combing the advantage of microemulsion and phospholipid complex Insulin phospholipid complex (IPC) was prepared by an anhydrous ...
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The present work explored the possibility of formulating oral insulin delivery system by combing the advantage of microemulsion and phospholipid complex Insulin phospholipid complex (IPC) was prepared by an anhydrous co-solvent lyophilization *** parameters affecting formulation were *** preparation has unimodal particle size distribution with a mean diameter of 27.3±*** results of bioactivity evaluation indicated that insulin was able to withstand the preparation *** was protected from enzymes by incorporation into oil *** IPC-microemulsion was effective in enhancing insulin transport across caco-2 cell *** IPC-microemulsion especially the IPC-W/O microemulsion was effective in reducing blood glucose level in diabetic animal *** complex based microemulsion appear to be an interesting candidate for oral delivery of insulin.
Objective To explore the effective ingredients of traditional Chinese medicine compound in different aperture dynamic migration patterns in the process of ceramic membrane microfiltration, compare it's micro f...
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Objective To explore the effective ingredients of traditional Chinese medicine compound in different aperture dynamic migration patterns in the process of ceramic membrane microfiltration, compare it's micro filtration flux and solid inclusion removal rate by taking Compound Banlangen Liyan Granules (Radix Isatidis, Radix Scrophulariae, Radix Platycodi, Radix Glycyrrhizae, etc.) water extraction liquid as the research object.
Objective: In this research, a novel vinorelbine-loaded aptamer (Apt) conjugated lipid-polymer hybrid nanoparticles (Apt-NP/VRL) were constructed for specific targeting MUC 1 protein over expressed tumor ***: Apt-NP/V...
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Objective: In this research, a novel vinorelbine-loaded aptamer (Apt) conjugated lipid-polymer hybrid nanoparticles (Apt-NP/VRL) were constructed for specific targeting MUC 1 protein over expressed tumor ***: Apt-NP/VRL were prepared by self-assembling method using lecithin, DSPE-PEG2ooo-COOH, and poly (lactic-co-glycolic acid) (PLGA) as carrier *** formulation was optimized by orthogonal *** aptamer was conjugated to DSPE-PEG2000-COOH through EDC and NHS coupling (Figure 1).Though changing the ratio of DSPE-PEG200o-Apt, NPs with different aptamer densities were synthesized and ***-6 labeled nanoparticles (Apt-NP/Cou-6) were prepared to evaluate the cellular uptake *** anti-tumor activity of Apt-NP/VRL to MCF-7 cell and HpG2 cell was evaluated.
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