Gene therapy has become an important strategy in the treatment of various diseases such as cancer,AIDS,tissue engineering and *** gene transfer is a key prerequisite for gene ***,constructing an efficient and safe gen...
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Gene therapy has become an important strategy in the treatment of various diseases such as cancer,AIDS,tissue engineering and *** gene transfer is a key prerequisite for gene ***,constructing an efficient and safe gene delivery system is one of the most important tasks in current non-viral gene therapy ***(PEI) is the most widely used agent for in vitro gene ***,PEI has significant cytotoxicity and lacks an intrinsic capacity to enter the nucleus,release
Flavokawain A(FKA),a plant extract from the dry roots of piper methysticum,is a type of physiologically active component, known as a novel anticarcinogenic drug,and its interaction mechanisms were still *** the FKA ha...
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Flavokawain A(FKA),a plant extract from the dry roots of piper methysticum,is a type of physiologically active component, known as a novel anticarcinogenic drug,and its interaction mechanisms were still *** the FKA have poor stability and low bioavailability,which restrict the application of its use. Liposomes was a promising and effective vector in tumor *** antineoplastic agents are characterized by targeting tumor and controlled-release,and thus they can increase therapeutic index(TI),improve clinical effect and reduce toxicity.
Objective:The aim of this study was to investigate the intestinal absorption mechanism of Raltitrexed(RTX) and evaluate the effects of absorption enhancers on RTX intestinal absorption in vitro. Methods and results:Bi...
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Objective:The aim of this study was to investigate the intestinal absorption mechanism of Raltitrexed(RTX) and evaluate the effects of absorption enhancers on RTX intestinal absorption in vitro. Methods and results:Bi-directional transports of RTX at various concentrations through Caco-2 cell monolayer were investigated. Then the enhancement and toxic effects of absorption enhancers on the transport were *** results indicated that in the
作者：
Joseph P.Balthasar457B Cooke Hall
Department of Pharmaceutical SciencesUniversity at BuffaloState University of New York716-645-x.270
Pharmacokinetic and pharmacodynamic(PKPD) modeling is widely employed in the pharmaceutical industry to facilitate drug *** applications include:(a) Data Summarization:PKPD modeling allows efficient description of cli...
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Pharmacokinetic and pharmacodynamic(PKPD) modeling is widely employed in the pharmaceutical industry to facilitate drug *** applications include:(a) Data Summarization:PKPD modeling allows efficient description of clinical data sets of drug concentration *** information and drug effect vs. time data,which often include information from thousands of patients and tens of thousands of time-points. In many cases,PKPD modeling allows description of these expansive data sets through a small number of
The poor water solubility of many active compounds is a serious deterrent to their use as commercial *** often related to serious side effect,while inconvenient procedure and unsafety materials of nanoformulations sha...
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The poor water solubility of many active compounds is a serious deterrent to their use as commercial *** often related to serious side effect,while inconvenient procedure and unsafety materials of nanoformulations shadow their way to be clinical *** is a dual EGFR and HER2 inhibitor that is used to treat HER2-overexpressing ***,its poor water solubility hinders its clinical *** is a promising way to solve this *** by the structure of
Objective:To develop a novel kind of mesoporous TiO2 (MST) nanoparticle for loading and improving the dissolution rate of poorly water-soluble ***:the conventional calcination method was replaced by a simple ethanol e...
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Objective:To develop a novel kind of mesoporous TiO2 (MST) nanoparticle for loading and improving the dissolution rate of poorly water-soluble ***:the conventional calcination method was replaced by a simple ethanol extraction method to synthesize MST *** SEM/TEM,XRD,N2 adsorption/desorption,scanning calorimetry (DSC),thermogravimetric analysis (TGA) and in vitro dissolution test were used to explore the role of MST on drug loading and release behaviors.
Macromolecular therapeutic agents possess enormous potential to replace or complement conventional *** full efficacy,however,can be achieved only when combined with appropriate and efficient delivery carriers that are...
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Macromolecular therapeutic agents possess enormous potential to replace or complement conventional *** full efficacy,however,can be achieved only when combined with appropriate and efficient delivery carriers that are tailored to target and deliver to relevant subcellular compartments in target cells.A unique,targeted cytosolic delivery strategy for macromolecule drugs,combined with nano-sized drug carriers,has been developed utilizing the cell-invasion mechanism of an intracellular bacterium, Listeria *** cytosol-targeting mechanism of Listeria has been incorporated into existing
Despite advances in chemotherapy the 5-year survival rate of cancer still remains desperately low due to the severe toxic side effects and multidrug resistance(MDR).Herein,codelivery of apoptosis peptide/p53 DNA is pr...
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Despite advances in chemotherapy the 5-year survival rate of cancer still remains desperately low due to the severe toxic side effects and multidrug resistance(MDR).Herein,codelivery of apoptosis peptide/p53 DNA is proposed for adjuvant therapy in order to reduce adverse effects of chemotherapeutics and improve sensitivity of tumor cells to them(Fig.1).
The purpose of the present work was to explore the suitable application of MCM-41-type and MCM-48-type mesoporous silica as the oral drug vehicles for poorly water soluble drugs(Scheme.1).
The purpose of the present work was to explore the suitable application of MCM-41-type and MCM-48-type mesoporous silica as the oral drug vehicles for poorly water soluble drugs(Scheme.1).
作者：
Ick Chan KwonCenter for Theragnosis
Biomedical Research Instiitute Korea Institute of Science and Technology(KIST) 39-1 Haweolgog-dongSungbook-ku Seoul 136-791Korea
Imaging of enzyme activities is a crucial technique in development of theragnosis because it is indispensable in diagnosis of various *** example,it is well known that matrix metalloproteinases are abundant in patholo...
Imaging of enzyme activities is a crucial technique in development of theragnosis because it is indispensable in diagnosis of various *** example,it is well known that matrix metalloproteinases are abundant in pathological conditions such as cancer,osteoarthritis(OA),and rheumatoid arthritis(RA). Also protein kinases play an important role in cell *** addition,monitoring of therapeutic effect can be possible by visualization of caspase activities since they are closely related to apoptosis of *** developed new imaging probes to detect activities of various enzymes such as matrix metalloproteinases, caspase,and protein *** this presentation,it will be discussed,how we developed those probes and applied to visualize enzyme activities
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