Doxorubicin is one of the most promising chemotherapeutic agents for the treatment of androgen-independent prostate cancer, non-small-cell lung cancer and locally advanced or metastatic breast *** smart micelles are c...
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Doxorubicin is one of the most promising chemotherapeutic agents for the treatment of androgen-independent prostate cancer, non-small-cell lung cancer and locally advanced or metastatic breast *** smart micelles are composed of four key components:(1)a chemotherapeutic agent doxorubicin(DOX);(2)a TAT peptide that can induce endocytosis for cell uptake;(3)a pH sensitive compound SA-SD which is loaded at the hydrophobic core of each micelle;(4)a biodegradable PEG-PE.
Nanoparticles have been successfully used to improve bioavailability of poorly water soluble *** particles are mainly produced by media milling *** processes for nanonization incorporate single droplet evaporation or ...
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Nanoparticles have been successfully used to improve bioavailability of poorly water soluble *** particles are mainly produced by media milling *** processes for nanonization incorporate single droplet evaporation or precipitation of drug particle in the nanosized *** key objective of using nanoparticles of pure drugs is to increase the surface area leading to better dissolution ***, nanoparticles may form aggregates which will reduce the total surface area available for dissolution. Development of a suitable method for measuring the dissolution rate,and formulation strategies along with
Gene therapy has gained more and more attention over the past two decades for treatment of both inherited and acquired *** positive characteristics make chitosan a good gene carrier *** order to improve the transfecti...
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Gene therapy has gained more and more attention over the past two decades for treatment of both inherited and acquired *** positive characteristics make chitosan a good gene carrier *** order to improve the transfection efficiency of chitosan,stearic acid was covalently modified to chitosan to obtained the graft polymer(CSOSA),which
The pulmonary delivery of therapeutic proteins has attracted rapidly increasing attentions for the treatment of local and systemic diseases such as cancers,diabetes and myocardial *** dry powder inhaler formulations o...
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The pulmonary delivery of therapeutic proteins has attracted rapidly increasing attentions for the treatment of local and systemic diseases such as cancers,diabetes and myocardial *** dry powder inhaler formulations offer advantages over other pulmonary delivery devices including enhanced stability,ease of administration and relatively simple *** deposition site of inhaled particles in the respiratory way is closely related to their aerodynamic *** particle size for efficient delivery
Aim:To introduce AS1411 (this aptamer targets nucleolin on the cell surface) to complex between ADM and SWNT to enhance targeted delivery of ADM,and to use 808 nm NIR laser for photothermal treatment to achieve the ef...
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Aim:To introduce AS1411 (this aptamer targets nucleolin on the cell surface) to complex between ADM and SWNT to enhance targeted delivery of ADM,and to use 808 nm NIR laser for photothermal treatment to achieve the effect of targeting,controlled release and ***:Water-soluble SWNTs were made by oxidizing and functionalizing with poloxamer ***-AS1411-SWNTs tertiary complex formation was formed according physical adsorption and electrostatic adsorption,lt was analyzed by TEM,infrared spectrophotometry,differential scanning calorimeter,particle size and potential analysis.
Aim:The aim of his study was to investigate the possibility to use the bone marrow-derived mesenchymal stem cells (BMSCs) as a pulmonary targeting gene micro/nano-vector in the therapy for anti-metastatic lung cancer ...
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Aim:The aim of his study was to investigate the possibility to use the bone marrow-derived mesenchymal stem cells (BMSCs) as a pulmonary targeting gene micro/nano-vector in the therapy for anti-metastatic lung cancer combined with ganciclovir/herpes simplex virus thymidine kinase (GCV/HSV-tk) prodrug anti-tumor system.
Aims:Hyaluronic acid (HA)/polyethyleneimine-dexamethasone (PEI-Dex)/DNA ternary complexes were developed for targeted gene delivery to improve the transfection efficiency and decrease the cytotoxicity of polycation no...
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Aims:Hyaluronic acid (HA)/polyethyleneimine-dexamethasone (PEI-Dex)/DNA ternary complexes were developed for targeted gene delivery to improve the transfection efficiency and decrease the cytotoxicity of polycation non-viral gene ***:The formation of ternary complex was evaluated by gel retardation *** particle size,zeta potential and morphology of ternary complexes were *** transfection effciency,cytotoxicity,in vitro cellular uptake were evaluated *** was analyzed by MTT assay.
Aims:A novel ligend-PEG-drug conjugate,octreotide-polyethene glycol-paclitaxel (OCT-PEG-PTX) was developed for efficient cancer ***:The ligand OCT was first conjugated to the carboxyl group of PEG by EDC reaction (OCT...
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Aims:A novel ligend-PEG-drug conjugate,octreotide-polyethene glycol-paclitaxel (OCT-PEG-PTX) was developed for efficient cancer ***:The ligand OCT was first conjugated to the carboxyl group of PEG by EDC reaction (OCT-PEG)and then the paclitaxel was conjugated to OCT-PEG by using succinic anhydride as a spacer (OCT-PEG-PTX).Non-targeted prodrug,PEG-PTX,was also synthesized as *** chemical structures and physicochemical properties were characterized indetail.
Aims:The purpose of this work was to find out whether the bioavailability of silymarin can be improved by administering silymarin incorporated in N-dodecyl-N,O-carboxymethyl chitosan (DCC) ***:DCC with different degre...
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Aims:The purpose of this work was to find out whether the bioavailability of silymarin can be improved by administering silymarin incorporated in N-dodecyl-N,O-carboxymethyl chitosan (DCC) ***:DCC with different degree of substitution (DS) of alkyl chains were synthesized and the chemical structure was characterized by Fourier transform infrared,1H nuclear magnetic resonance,and elemental ***-loaded DCC micelles were prepared by using a simple dialysis process.
The limited solubility and dissolution rate exlhibited by poorly soluble drugs is major challenges in the pharmaceutical *** oral administration,the poorly soluble drugs generally show a low and erratic bioavailabilit...
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The limited solubility and dissolution rate exlhibited by poorly soluble drugs is major challenges in the pharmaceutical *** oral administration,the poorly soluble drugs generally show a low and erratic bioavailability which may lead to therapeutic *** drug nanocrystals,generated by "bottom up" or "top down" technologies,facilitate a significant improvement on dissolution behavior of poorly soluble drags due to their enormous surface area,which in turn lead to substantial improvement in oral absorption.
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