Objective To prepare vincristine sulfate-loaded solid lipid nanoparticles(VCR-SLN),optimize formulation,investigate their pharmaceutical characters,pharmacokinetics in vivo in rats,anti-MDA-MB-231 cell activity in vit...
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Objective To prepare vincristine sulfate-loaded solid lipid nanoparticles(VCR-SLN),optimize formulation,investigate their pharmaceutical characters,pharmacokinetics in vivo in rats,anti-MDA-MB-231 cell activity in vitro,and to improve VCR Sustained-release and long-acting used nanoparticles as a carrier. Methods VCR-SLN was prepared by double emulsion solvent evaporation(w/o/w) *** of VCR-SLN were observed by transmission *** particle size and Zeta potential were estimated by laser particle size analyzer. Entrapment efficiency and drug loading were investigated by the method of *** rats were selected as
Introduction:The delivery of therapeutic proteins and peptides in their unmodified form has several limitations,which include poor stability,low solubility,short in vivo circulation,and *** proteins and peptides with ...
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Introduction:The delivery of therapeutic proteins and peptides in their unmodified form has several limitations,which include poor stability,low solubility,short in vivo circulation,and *** proteins and peptides with polyethylene glycol (PEG),termed PEGylation,is one strategy to overcome these *** methods for the synthesis of protein-polymer conjugates for therapeutic applications must:(1) be carried out in aqueous conditions,and provide:(2) a stoichiometric conjugate (typically 1:1);with(3) complete control of the site of conjugation;at(4) high yield(>50%);with(5) good control of polymer
Coenzyme Q(CoQ),a cutaneous antioxidant,has been proved to prevent the ultraviolet radiation（UV） skin injure,but its high lipid solubility limits the utilization on UV *** most critical life threats to astronauts in...
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Coenzyme Q(CoQ),a cutaneous antioxidant,has been proved to prevent the ultraviolet radiation（UV） skin injure,but its high lipid solubility limits the utilization on UV *** most critical life threats to astronauts in long-term space missions is UV radiation induced damage,therefore,an optimized formulation containing CoQio would relieve the UV impairment to skin. Objective:Microemulsion is an innovative carrier system for dermal application,which to enhance penetration of active compounds
Diseases that cause impaired human organs and tissues have increased due to an expanded life span, natural disasters,and other *** essential factors in regenerative therapy include cells,scaffolds and delivery technol...
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Diseases that cause impaired human organs and tissues have increased due to an expanded life span, natural disasters,and other *** essential factors in regenerative therapy include cells,scaffolds and delivery technology of bioactive *** cells have been in extremely high demands for tissue regeneration;however,they are somewhat limited in functionality over passages,differentiation potential and sufficient sourcing.
Aim of the study:This study was to investigate the novel preparation of the solid lipid nanoparticle-enriched hydrogel (SLN-gel) for the topical delivery of astragaloside Ⅳ,as well as to study the influence of astrag...
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Aim of the study:This study was to investigate the novel preparation of the solid lipid nanoparticle-enriched hydrogel (SLN-gel) for the topical delivery of astragaloside Ⅳ,as well as to study the influence of astragaloside Ⅳ based SLN-gel on wound healing and scar *** and methods:Solid lipid nanoparticle (SLN) was prepared by solvent evaporation method with glycerol tristearate and poloxamer 188 as lipid phase and surfactant,*** particle size,polydispersity index (PDI),zeta potential (ZP),encapsulation efficiency (EE),drug release and morphological properties were characterized.
Background The solubility of C in polar solvents is quite low,therefore many water-soluble derivatives of C have been synthesized for biological *** laboratory data suggests that angiogenesis plays an essential role i...
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Background The solubility of C in polar solvents is quite low,therefore many water-soluble derivatives of C have been synthesized for biological *** laboratory data suggests that angiogenesis plays an essential role in breast cancer development, invasion and metastasis,and the Asn-Gly-Arg（NGR） peptide motif has been shown to specifically bind to CD13/amino peptidase N,the tumor vascular antigen,and used as a targeting head for target drugs to improve biodistribution and be more effective
Objective:Prepared the non-viral delivery carrier with high transfection ***:(1) Synthesis of mPEG-chitosan:EDC were added into 5ml aqueous solution containing mPEG-COOH and chitosan,the solution was stirred 24 h and ...
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Objective:Prepared the non-viral delivery carrier with high transfection ***:(1) Synthesis of mPEG-chitosan:EDC were added into 5ml aqueous solution containing mPEG-COOH and chitosan,the solution was stirred 24 h and precipitated using diethyl *** obtained precipitate was redissolved and dialyzed 24 h in aqueous solution using a dialysis ***,the
Objective:The objective of this study was to investigate the effect of polymorphism of glycerol monostearate(GMS) on the drug incorporation and ***:Fenofibrate was used as the model drug.X-ray powder diffraction(XRPD)...
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Objective:The objective of this study was to investigate the effect of polymorphism of glycerol monostearate(GMS) on the drug incorporation and ***:Fenofibrate was used as the model drug.X-ray powder diffraction(XRPD) and differential scanning calorimetry(DSC) were used to study the effect of Medium-Chain Triglyceride(MCT) on the polymorphism of GMS and
A smart zwitterionic oligopeptide liposome (HHG2C18-L) has been demonstrated to have multistage pH-response to mildly acidic tumor extracellular matrix and intracellular compartment for increased cellular uptake,enhan...
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A smart zwitterionic oligopeptide liposome (HHG2C18-L) has been demonstrated to have multistage pH-response to mildly acidic tumor extracellular matrix and intracellular compartment for increased cellular uptake,enhanced cytoplasmic distribution and good mitochondrial targeting [1].In order to further improve the in vivo stability and bioavailability,the PEGylated zwitterionic oligopeptide liposome (PEGHG2C18-L) was constructed based on the formulation of HHG2C18-L by decorating it with ***2C18-L also presented high cellular uptake at tumor pH by charge conversion,and efficient mitochondrial targeting effect.
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