Folate receptor a is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer *** order to develop folate receptor o-mediated gene therapy for ovarian cancer,folate-poly（ethylene g...
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Folate receptor a is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer *** order to develop folate receptor o-mediated gene therapy for ovarian cancer,folate-poly（ethylene glycol）-succinate-cholesterol （F-PEG-suc-Chol） was synthesized,characterized by H-NMR and Q-TOF mass spectrum,and used to prepare fo late-targeted cationic liposomes / plasmid DNA complexes（F-targeted lipoplexes）.Post-insertion method was used to prepare F-targeted
Background Graphene oxide(GO) is a novel one-atom-thick two-dimensional graphitic carbon system,have led to much excitement in recent years in material science and condensed-matter physics Because of favorable physica...
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Background Graphene oxide(GO) is a novel one-atom-thick two-dimensional graphitic carbon system,have led to much excitement in recent years in material science and condensed-matter physics Because of favorable physical and biological *** has attracted significant attention from material *** instance,the solubility of GO nano-sheets in water and other polar solvents has led to their consideration for applications including nano-electronics,sensors,and *** acid(FA) is a
The study aimed to develop a biomimetic nanovector,reconstituted high density lipoprotein (rHDL),mediating targeted cholesterol-conjugated siRNA (Chol-siRNA) delivery for Pokemon gene silencing ***-siRNA-loaded rHDL n...
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The study aimed to develop a biomimetic nanovector,reconstituted high density lipoprotein (rHDL),mediating targeted cholesterol-conjugated siRNA (Chol-siRNA) delivery for Pokemon gene silencing ***-siRNA-loaded rHDL nanoparticles (rHDL/Chol-siRNA complexes) were prepared using thin-film dispersion method and their characteristics were investigated in ***/Chol-siRNA complexes at the optimal volume ratio (lipid:Chol-siRNA) exhibited high Chol-siRNA-loading efficiency(~99%),desirable nanoparticle size and excellent stability in serum.
Background and Objective Conventional anti-cancer drugs often have some unexpected limitations such as limited solubility,poor distribution and lack of *** order to overcome these problems,nano-sized delivery vehicles...
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Background and Objective Conventional anti-cancer drugs often have some unexpected limitations such as limited solubility,poor distribution and lack of *** order to overcome these problems,nano-sized delivery vehicles have been employed to improve the pharmacological and therapeutic properties of the anti-cancer ***-walled carbon nanotubes(SWNTs) are emerging as one of the most promising delivery vehicles for cancer diagnose and chemotherapy due to their significant advantages over the spherical
Purpose:The pharmacological activity of herbal medicines is determined by the active component ratio that defines the medicine, significant alteration of the component ratio will lead to major changes in pharmacologic...
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Purpose:The pharmacological activity of herbal medicines is determined by the active component ratio that defines the medicine, significant alteration of the component ratio will lead to major changes in pharmacological *** designing of sustained and controlled release delivery systems is very important to maintain the component ratios during the release process.
Aim:The aim of this study was to develop an efficient vector for gene delivery into the brain. Methods:Phage-displayed TGN peptide decorated polyion complexes based on PEGylated poly(2-(dimethylamino) ethyl methacryla...
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Aim:The aim of this study was to develop an efficient vector for gene delivery into the brain. Methods:Phage-displayed TGN peptide decorated polyion complexes based on PEGylated poly(2-(dimethylamino) ethyl methacrylate) were prepared for brain targeting gene *** shape of PICs were observed using *** uptake of YOYO-1-labeld PICs was visualized under fluorescent microscope and analyzed using a flow *** near-infrared
Purpose Penetratin(PEN),one of most promising cell penetrating peptides(CPPs),was chemically modified to upgrade its permeation enhancing effect for the co-administered ***-2CD,a derivative of PEN was evaluated as nov...
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Purpose Penetratin(PEN),one of most promising cell penetrating peptides(CPPs),was chemically modified to upgrade its permeation enhancing effect for the co-administered ***-2CD,a derivative of PEN was evaluated as novel epithelium permeation enhancers for oral insulin delivery.
Coaxial electrospinning,in which a concentric spinneret can accommodate two different solutions,can easily duplicate the structure of macro jet devices(concentric spinneret) to generate nano products with core-sheath ...
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Coaxial electrospinning,in which a concentric spinneret can accommodate two different solutions,can easily duplicate the structure of macro jet devices(concentric spinneret) to generate nano products with core-sheath *** traditional concept about coaxial electrospinning is that the sheath fluids must have good electrospinnability and enough viscosity to overcome the interfacial tension between the two solutions through "viscous dragging" and "contact friction" for a successful coaxial
Lansoprazole is a substituted benzimidazole and selectively inhibits the H+/K+-***,the bioavailability of LSP was not constant with wide inter-subject variation,which is ascribed to the variation in the genotype of CY...
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Lansoprazole is a substituted benzimidazole and selectively inhibits the H+/K+-***,the bioavailability of LSP was not constant with wide inter-subject variation,which is ascribed to the variation in the genotype of CYP2C19,sensitivity to low pH and light and limited water solubility. In this study,lansoprazole(LSP)/cyclodextrin(CD) inclusion complexes were prepared using a fluid-bed coating technique to
In this work,we report a Pluronic P123 lipid bilayer supported mesoporous silica nanoparticles (PLB-MSNs) to stimulate drug release in multidrug-resistant (MDR) cancer *** a novel core-shell hybrid system,the supporte...
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In this work,we report a Pluronic P123 lipid bilayer supported mesoporous silica nanoparticles (PLB-MSNs) to stimulate drug release in multidrug-resistant (MDR) cancer *** a novel core-shell hybrid system,the supported membrane acted as an intact barrier against the escape of encapsulated molecules and significantly increased cellular uptake in drug sensitive MCF-7 and drugresistant MCF-7/BCRP cells compared with conventional MSNs.
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