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检索条件"任意字段=2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会"

共 592 条记录，以下是441-450 订阅

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Characteristics of sequential targeting to brain glioma for transferrin-modified cisplatin liposome

Characteristics of sequential targeting to brain glioma for ...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Qing Lv Min Han Fan-Zhu Li Jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058Ch Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058Ch College of Pharmaceutical Science Zhejiang Chinese Medical UniversityHangzhou 310053China.

Objective:Methods on how to improve the sequential targeting of glioma subsequent to passing of drug through the blood-brain barrier (BBB) have been occasionally ***,the characteristics involved are poorly *** prepared a cisplatin loaded liposomal carrier modified with transferrin(Tf),expecting it to transport through BBB and sequential target C6 glioma cells,and the characteristics of"sequential-targeting" for lipsomes(Tf) were further studied.

关键词： sequential-targeting brain-targeted delivery transferring cisplatin glioma

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Hyaluronic acid-based polymeric nanoparticles for targeting delivery of paclitaxel

Hyaluronic acid-based polymeric nanoparticles for targeting ...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Jing Yao Li Zhang Jianping Zhou Hongpan Liu Department of Pharmaceutics China Pharmaceutical University24 TongjiaxiangNanjing 210009China Sta Department of Pharmaceutics China Pharmaceutical University24 TongjiaxiangNanjing 210009China

Aims:Based on the self-assembled properties of amphiphilic polymers and HA-mediated tumor targeting,amphiphilic hyaluronic acid (HA)-based derivative was developed as a carrier of paclitaxel (PTX) to improve the solubility of PTX and facilitate its tumor targeting ***:PTX-loaded polymeric nanoparticles were prepared by the dialysis *** effect of degree of substitution (DS) of hydrophobic section in polymers on drug loading,entrapment efficiency and particles size were *** in vivo drug release was also *** addition,confocal microscopy was used to internalize the intracellular location ofnanoparticles.

关键词： Hyaluronic acid Polymeric nanoparticles Tumor targeting Paclitaxel

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Dual-decorated liposomes for tumor targeting drug delivery

Dual-decorated liposomes for tumor targeting drug delivery

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Tianyue Jiang Jianping Zhou Huixia Lv Department of Pharmaceutics China Pharmaceutical UniversityNanjing 210009P.R.China

Dual-decorated liposomes with pH-selective cell penetrating peptides (CPPs) and active tumor targeting hyaluronic acid (HA) were fabricated for targeting anticancer drug delivery.A series of novel synthetic tumor pH-triggered CPPs were screened by comparing tumor cellular uptake efficiency at pH 6.4 with at pH 7.4,and R6H4 (RRRRRRHHHH) rich in arginines and histidines was obtained for the strongest *** construct R6H4-modified liposomes (R6H4-L),R6H4 with stearyl was anchored into liposomes due to hydrophobic interaction.

关键词： pH-selectivity cell penetration peptides hyaluronic acid liposomes tumor targeting drug delivery

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Novel temperature-sensitive liposome gel based on N-Cholesteryl hemisuccinate-O-sulfate chitosan (NCHOSC) polymer for nasal delivery system

Novel temperature-sensitive liposome gel based on N-Choleste...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Daquan Chen Kaoxiang Sun Hongjie Mu Yan Shen Qineng Ping Jiasheng Tu Wanhui Liu State Key Laboratory of Longacting and Targeting Drug Delivery System YantaiPeople''s Republic of China School of PharmacyYantai UniversityYantaiPeople''s Republic of China College of PharmacyChina Pharmaceutical UniversityNanjingPeople''s Republic of China School of Pharmacy Yantai UniversityYantaiPeople''s Republic of China

In this study,a biomimetic polymer of blood cell membrane,N-Cholesteryl hemisuccinate-O-sulfate chitosan (NCHOSC) was synthesized and characterized.A temperatur-sensitive liposome gel based on NCHOSC polymer has been applied to nasal *** curcumin-liposome was engineered to form thermogel at body temperature and degrade in an temperature environment.

关键词： NCHOSC polymer thermosensitive liposome gel nasal delivery

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Paclitaxel-loadedpoly(ethyleneglycol)-block-poly(y-cholesterol-L-glutamate) nanoparticles for loading and evaluation

Paclitaxel-loadedpoly(ethyleneglycol)-block-poly(y-cholester...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Oing Ma,Yang Wu,Xiangrong Song,Jingkun Zhang,Gu He State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,610041

The purpose of this study was to develop a polymeric drug delivery system for paclitaxel,intended to improving safety and capability of drug *** achieve this goal,Paclitaxel(PTX)-loaded Polyethylene glycol)-block-poly(y-cholesterol-L-glutamate) (mPEG-PChLG) nanoparticles were ***-PChLG was a modification of PEG-poly(P-benzyl-L-aspartate)(PEG-PBLG), it could be completelly non-toxic biodegraded in ***-mPEG-PChLG nanoparticles were prepared via OAV emulsion solvent evaporation,it showed the spherica shape and steadily dispersed suspension(Fig.1).Furthermore,the drug-loading coefficient could

关键词： Paclitaxel mPEG-PChLG Nanoparticle Loading Anticancer

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Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization

Enhanced dissolution and oral bioavailability of aripiprazol...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Yin Xu Mingzhu Shangguan Xiaoyi Liu Ruyue Lian Siyi Zheng Zongning Yin Yi Lu Wei Wu School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug Delivery of Ministry of Education a Shanghai Zhong Xi Pharmaceutical(Group)Co. Ltd.Shanghai200065PR China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug Delivery of Ministry of Education a West China School of Pharmacy Sichuan UniversityChengdu610041PR China

Reducing the particle size of drugs to produce nanosuspensions or nanocrystals,is quite advantageous for poorly soluble drugs to enhance their *** to the deficiency of conventional nanoprecipitation techniques,it is d... 详细信息

关键词： nanosuspensions acid-base neutralization aripiprazole solubility dissolution oral bioavailability

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Preparation of Surface modification polylactide drug-loaded nanoparticles for intranasal delivery and evaluation on its brain targeting efficiency

Preparation of Surface modification polylactide drug-loaded ...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者：边俊杰徐超群袁志翔四川省中医药科学院四川省成都市人民南路四段51号

BACKGROUND The human olfactory system is linked to a channel in the brain and the surrounding *** nasal administration,the drug can reach the brain through the following two ways.(1) blood circulation through the BBB to reach the brain.(2) directly through the olfactory region to reach the cerebrospinal fluid or even the *** studies have shown that the high degree of bioavailability of the certain drugs nasal delivery,and can even be comparable to the injection,but very little amount of drugs into the brain from the nasal pathway.

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Thermoresponsive self-assembled particles of elastin-like polypeptide for delivery of docetaxel

Thermoresponsive self-assembled particles of elastin-like po...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Juan Bi~(1,2)Qin He~2,Fengqian Li~(1*) 1 Department of Pharmaceutics,Shanghai Eighth People's Hospital,Shanghai 200235,P.R.China 2West China School of Pharmacy,Sichuan University,Chengdu 600041,P.R.China

OBJECTIVE:we attempt to exploit ELP[KV8F-40](Fig.l) of approximately 18kDa coorperatively synthesized by Lab of Zhang Guangya(Department of Bioengineering and Biotechnology,Huaqiao University) to fabricate self-assembled elastin-like polypeptide particles,and further to evaluate its thermosensitive characterization and the potential for package of the model drug docetaxel.

关键词： Elastin-like polypeptides Self-assembly Thermorespnsive Drug loading

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G3-C12 peptide as a novel kidney renal targeting drug carrier

G3-C12 peptide as a novel kidney renal targeting drug carrie...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Qian Geng Tao Gong Xun Sun Zhirong Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengduPeople''s Republic of China

Chronic kidney disease (CKD) is increasingly recognized as a major public health *** targeting delivery to the kidney is an attractive method to increase the drug efficacy,as this approach will generate higher renal drug *** extensively used as vehicles of radioactivity for targeted imaging and radiolabeled peptides also caused high and persistent localization of radioactivity in the kidney In addition,the renal uptake owes to the peptides carrier rather than the radiometabolite.

关键词： Kidney targeted drug delivery system Chronic kidney disease G3-C12 peptide Captopril Drug-carrier conjugate

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N-octyl-N-Arginine chitosan Micelles for insulin oral administration

N-octyl-N-Arginine chitosan Micelles for insulin oral admini...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Hui-Xia Lv Zhen-Hai Zhang Sarra Abbad Rui-Rui Pan Jian-Ping Zhou Department of Pharmaceutics China Pharmaceutical UniversityNanjingChina210009 Jiangsu Province Academy of Traditional Chinese Medicine NanjingChina210028

Aim:To synthesis a novel chitosan derivative,N-octyl-N-arginine chitosan(OACS),with a mimetic structure of Arginine rich *** micelles loaded Insulin (Ins-OACS) was prepared,characterized and ***:Octyl groups were introduced onto chitosan by nucleophilic addition and the subsequent *** the formed products were conjugated with arginine under the catalysis of EDC and NHS to form *** structure of OACS was evaluated by elemental analysis,spectrophotometry,FT-IR,1H NMR etc.

关键词： Chitosan N-octyl-N-Arginine chitosan Cell penetration peptides insulin Arginine-rich polymeric micelles Oral administration

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