Objective:Toxin protein of immunotoxin produces a strong non-specific toxicity in the body,and greatly limits their broad clinical ***2:342-PE38KDEL-loaded anti-HER2 PEGylated liposomes(ZP-Affisomes) were ***:Particle...
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Objective:Toxin protein of immunotoxin produces a strong non-specific toxicity in the body,and greatly limits their broad clinical ***2:342-PE38KDEL-loaded anti-HER2 PEGylated liposomes(ZP-Affisomes) were ***:Particle size and morphology of ZP-Affisomes and ZP-liposomes were observed by dynamic light-scattering detector (DLS) and transmission electron microscope (TEM).BCA assay was used to determine the drug loading,encapsulation efficiency,and high performance liquid chromatogaphy(HPLC) was used to determine ZHER2:342 conjugation efficiency on the ZP-liposomes.
Objective:The main goal of this study was to develop novel compound components of Danshen and Sanqi loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and evaluate their potential in protective effects ...
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Objective:The main goal of this study was to develop novel compound components of Danshen and Sanqi loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and evaluate their potential in protective effects on brain injury via inner ear ***:PLGA NPs loaded with salvianolic acid B (Sal B),tanshinone IIA (TS ILA) and panax notoginsenoside (PNS) (notoginsenoside R1 and ginsenoside Rg1,Rb1) were prepared by double emulsion/solvent evaporation *** were
Diabetes,the source of many deadly diseases,has been considered as the most dangerous epidemics in the *** therapeutic approaches are varied according to different type of *** insulin therapy is always an important tr...
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Diabetes,the source of many deadly diseases,has been considered as the most dangerous epidemics in the *** therapeutic approaches are varied according to different type of *** insulin therapy is always an important treatment method for both types of *** administration is an ideal route but limited by the intrinsic instability of ***,subcutaneous (sc) injection is still the main route for insulin ***,however,the diabetic patients have to receive injections for as lease once a day,which brings lots of troubles and pains and leads to a very low patient compliance.
Chlorogenic acid,with its chemical name 3-caffeoylquinic acid,is a styrene-acrylic grain compound obtained by the condensation of caffeic acid and quinic *** widely exists in the plants like Japanese Honeysuckle Flowe...
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Chlorogenic acid,with its chemical name 3-caffeoylquinic acid,is a styrene-acrylic grain compound obtained by the condensation of caffeic acid and quinic *** widely exists in the plants like Japanese Honeysuckle Flower Bud,Wild chrysanthemum,Eucommia Bark,Dandelion,Capillary Wormwood Herb and *** acid has a wide range of biological activities,such as cholagogic effect,antibiosis,antivirus,stabilizing blood glucose,increasing the white blood cells, stopping bleeding,shortening the blood clots and bleeding time and enhancing the immune system and *** microspheres are prepared by existing microspheres preparation *** the adhesion effect of adhesive material added in the carrier,the microspheres can adhere to the aimed mucous layer,as well as to release the drug in a sustained manner,thus to improve the absorption degrees and bioavailability of the ***,chlorogenic acid was used as a model drug to prepare the bioadhesive microspheres in order to improve its oral bioavailability.
Introduction Recombinant adenovirus serotype 5(Ad5),due to their high efficiency and low pathogenicity,has been the most popular nano-tool among clinical gene delivery ***,generation and prevelence of anti-adenovirus ...
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Introduction Recombinant adenovirus serotype 5(Ad5),due to their high efficiency and low pathogenicity,has been the most popular nano-tool among clinical gene delivery ***,generation and prevelence of anti-adenovirus neutralizing antibody(NAb) in human severely restricts the utilization of Ad5 vectors in gene therapy for a wide range of clinical trials. To overcome the limitation,we designed to ionically complex Ad5 with a newly synthesized copolymer(APC),fabricating a shielded adenovirus nanoparticle complexes from NAb.
Objective To optimize the preparation of Sirolimus-Nanostructured Lipid Carriers(SRL-NLC)dispersion,and study in vitro *** Apply Central composite design-response surface methodology for optimizing dispersion formulat...
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Objective To optimize the preparation of Sirolimus-Nanostructured Lipid Carriers(SRL-NLC)dispersion,and study in vitro *** Apply Central composite design-response surface methodology for optimizing dispersion formulation,then to explore in vitro dissolution in 0.4%SDS(sodium lauryl sulfate)solution by normal phase filter bag *** The optimal dispersion has PS(Particle Size):82.54 nm,PI(Polydisperity Index):0.207,Zeta potential:-18.0 mv,DL(Drug-loading):1.829%,and EE(Entrapment Efficiency):91.3%;SRL-NLC dispersion has 120 h dissolution characterization in 0.4%SDS solution by reverse phase dialysis bag method,and accumulated dissolution is 69.2%.Conclusions in vitro dissolution curve shows SRL-NLC dispersion has a characterization of 69.2%accumulated dissolution in 0.4%SDS solution.
Objective:To investigate the possibility of fingerprints techniques applied in the Yiqing capsule quality control. Method:HPLC fingerprint was used to screen the compositions content in traditional Chinese herb extrac...
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Objective:To investigate the possibility of fingerprints techniques applied in the Yiqing capsule quality control. Method:HPLC fingerprint was used to screen the compositions content in traditional Chinese herb extracts during producing process of Yiqing capsule.10 times the equivalent clinical dose of the drug was chronically administered to *** the compositions in the serum were assessed. Result:Via HPLC fingerprint techniques,the quality and quantity of main compositions in Yiqing capsule were well controlled as shown in Fig.1-Fig.3. Conclusion:The study suggested that the combination of HPLC fingerprints of herbal medicines and the chemo metric evaluation might be a powerful tool for quality control of Yiqing capsule.
INTRODUCTION Ethosome,or ethanol-containing liposome originally developed for transdermal drug delivery,is a liposome-based vesicle mainly composed of phospholipids and ethanol.1"2 Compared with conventional lipo...
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INTRODUCTION Ethosome,or ethanol-containing liposome originally developed for transdermal drug delivery,is a liposome-based vesicle mainly composed of phospholipids and ethanol.1"2 Compared with conventional liposome,the membrane flexibility and permeability of ethosome are greatly increased and can therefore adapt its shape to ambient easily and rapidly and deliver therapeutic agents across
Objective:This study aims at optimizing a liposomal delivery system co-modified with TAT and cleavable PEG in terms of the chain lengths and percentages of cleavable PEG and PEG connecting TAT in order to make it more...
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Objective:This study aims at optimizing a liposomal delivery system co-modified with TAT and cleavable PEG in terms of the chain lengths and percentages of cleavable PEG and PEG connecting TAT in order to make it more suitable for the targeted delivery of anticancer drug DOX before the drug was encapsulated and tested in vitro and in vivo. Methods:Liposomes were prepared by thin film-hydration *** In vitro uptake of DOX loaded liposomes,different
Objective C nanosuspensions rang from 150-200nm may have the ability to avoid be recognized by RES（reticuloendothelial system） and to target to systemic circulation,which will increase its bioavailability and safety...
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Objective C nanosuspensions rang from 150-200nm may have the ability to avoid be recognized by RES（reticuloendothelial system） and to target to systemic circulation,which will increase its bioavailability and safety'1'*** due to hydrophobicity of C,the success of forming nanosuspensions in water has to depend on the aid of stabilizing agents which would yield side effect more or *** our study,two methods and a myriad of factors were detected to find out an optimal C nanosuspensions(nano C) without any
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