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检索条件"任意字段=2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会"

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Synergistic enhancement of cancer therapy using photodynamic therapy induced by a new nano photosensitizer C60 and docetaxel

Synergistic enhancement of cancer therapy using photodynamic...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Jinjin Shi,Lei Wang,Zhenzhen Wang,Lulu Li,Honghong Wang,Zhenzhong Zhang~* School of Pharmaceutical Sciences,Zhengzhou University,100 Kexue Avenue,Zhengzhou 450001,Henan,P.R.China

Background Fullerenes(C60) have some potential biological effects,such as inhibition of HTV protease,antiviral activity,specific cleavage of DNA and photodynamic therapy(PDT)(1,2).C60 also has a great potential to be used as a antitumor drug carrier(2).Docetaxel (DTX),a first line cancer chemotherapeutic,which is in the treatment of a wide spectrum of cancers(3).Folic acid(FA),which can be used as a targeting head for target drugs to improve biodistribution and be more effective tumor therapy(4).In the present study,

关键词： Synergistic enhancement of cancer therapy using photodynamic therapy induced by a new nano photosensitizer C60 and docetaxel

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A novel mesoporous Ti02 with well defined morphology obtained by facile method:Impact of Ti02 architecture on drug loading and release behaviors

A novel mesoporous Ti02 with well defined morphology obtaine...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Haitao Jiang,Tianyi Wang,Jing Wang,Tongying Jiang and Siling Wang~* * Shenyang Pharmaceutical University,110016,PR China

Objective:To develop a novel kind of mesoporous TiO（MST）nanoparticle for loading and improving the dissolution rate of poorly water-soluble ***:the conventional calcination method was replaced by a simple ethanol extraction method to synthesize MST *** SEM/TEM,XRD,N adsorption/desorption,scanning calorimetry（DSC）,thermogravimetric analysis（TGA）and in vitro dissolution test were used to explore the role of MST on drug loading and release behaviors.

关键词： ordered mesoporous TiO2 poorly water-soluble drugs in vitro dissolution

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Synergistic targeted delivery of payload into tumor cells by dual-ligand liposomes modified with transferrin and TAT

Synergistic targeted delivery of payload into tumor cells by...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Li Zhang,Jie Tang.Yayuan Liu,Qianyu Zhang,Yao Qin,Yujia Yin,Wenmin Yuan,Yuting Yang,Zhirong Zhang,Yafei Xie,Hang Wang,Qin He~*. Key Laboratory of Drug Targeting and Drug Delivery Systems,West China School of Pharmacy,Sichuan University.Chengdu, Sichuan province,610041,P.R.China

Objective:The objective of this study was to develop an efficient dual-ligand liposomal delivery system co-modified with transferring(TF) and TAT,which possessed increased cellular uptake efficiency and targeting specificity. Methods:Liposomes were prepared by the thin film - hydration *** the uptake study in vitro,HepG2,A2780 and HUVEC that possess different expressing level of TFR on the surface were incubated with liposomes labeled with CF-PE at 37℃for 4 hours.

关键词： Synergistic targeted delivery of payload into tumor cells by dual-ligand liposomes modified with transferrin and TAT HUVEC

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Induction of antitumor cytotoxic T cell responses through PLGA or lipid-enveloped PLGA nanoparticles mediated antigen delivery

Induction of antitumor cytotoxic T cell responses through PL...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Anna Bershteyn Tetsuya Ioji Department of Materials Science and Engineering Massachusetts Institute of TechnologyBostonMA 02115 Department of Immunology and lmmunotherapy Kurume University School of MedicineKurumeFukuoka 830-0011Japan

Nanotechnology-based antigen delivery has been developed as a vaccine strategy due to its dose-sparing and prolonged antigen presentation *** the current study,we examined the feasibility of nanoparticle(NP)-mediated delivery of antigenic peptides to efficiently induce cytotoxic T lymphocyte responses against tumor-associated self-antigens in C57BL/6 mouse *** biodegradable poly(D,L-lactide-co-glycolide) nanoparticle(PLGA-NP) carrying single murine melanoma antigenic peptides,

关键词： Induction of antitumor cytotoxic T cell responses through PLGA or lipid-enveloped PLGA nanoparticles mediated antigen delivery

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Oligoarginine-modified biodegradable nanoparticles:A novel delivery carrier for oral administration of insulin

Oligoarginine-modified biodegradable nanoparticles:A novel d...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Xiao-li Liu Wen-jian Zhang Cao Xie Gang Wei Wei-yue Lu Key Laboratory of Smart Drug Delivery Ministry of Education & PLA Department of Pharmaceutics School of PharmacyFudan UniversityShanghai201203PR China

In recent years,cell-penetrating peptides (CPPs) have been proven to be a useful tool in improving the membrane translocation capacity of bioactive macromolecules via covalent *** intestinal absorption of macromolecules can also be enhanced by electrostatic interaction with CPPs;however,the application of this strategy is restricted to negatively charged *** the present study,we devised an approach utilizing CPP-functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a carrier for the oral delivery of *** surfaces of pegylated PLGA nanoparticles were functionalized with arginine-rich poly(arginine)8 peptide enantiomers (L-R8 and D-R8) via a maleimide-mediated covalent conjugating procedure.

关键词： Cell-penetrating peptide oligoarginine nanoparticle poly(lactic-co-glycolic acid) intestinal absorption insulin

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A novel targeting strategy for ischemic brain by cRGD mediated liposomes

A novel targeting strategy for ischemic brain by cRGD mediat...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Qin Jing~1,Hou Jia~(1,2),Xie yunfei,Wang Jianxin~(1*),Li Yongji~(2*) Department of Pharmaceutics,Shool of Pharmacy,Fudan University,Shanghai 201203,China Department of Pharmaceutics,Shool of Pharmacy,Heilongjiang University of Traditional Medicine,Harbin,Heilongjiang,150040, China

Although brain tumor tandem targeting strategies mediated by receptors has shown success with intense research,it's difficult for these strategies to delivery therapeutic molecules into stroke brain that is characterized by cessation of cerebral blood flow and reperfusion of the occluded vessel.A typical feature of ischemic stroke is the inflammatory response with recruitment of leukocytes to the site of *** leukocytes mainly include monocytes and *** RGD sequence(Arg-Gly-Asp) is known to serve as a recognition motif in multiple ligands for integrin av|31,which is highly expressed on the surface of *** coupling with

关键词： A novel targeting strategy for ischemic brain by cRGD mediated liposomes THP

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Influence of hydrophilic solid lipid nanoparticles on the absorption of drug in gastrointestinal tract

Influence of hydrophilic solid lipid nanoparticles on the ab...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Hong Yuan Chun-Yan Chent Yong-Zhong Du Fu-Qiang Hu College of Pharmaceutical Science Zhejiang Uniersity866 Yuhangtang RoadHangzhou 310058P.R.China

Objective:During the last decade years,Caco-2 cell monolayers have been used as an intestinal model to evaluate the effect of delivery systems on drug permeation via transcellular and paracellular *** it lacks goblet,mucus-secreting and *** order to better simulate the endosomatic environment in vitro,HT-29 subclones have been used in co-culture with Caco-2 cells to mimic the small intestinal epithelial *** aim of this study was to evaluate the transport properties of solid lipid nanoparticles (SLN) across Caco-2 and mucus-secreting Caco-2/HT29 co-culture cell monolayers.

关键词： Caco-2 cells HT-29 cells solid lipid nanoparticles otcadecylamine-fluorescein isothiocyanate doxorubicin(DOX) solvent diffusion method Oral drug delivery

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Preparation and in vitro release of paliperidone oil suspension

Preparation and in vitro release of paliperidone oil suspens...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Wang dan Zhao dongyang Zhang kaikai Sun fengying Li youxin College of life science Jilin UniversityChangchun 130012China

OBJECTIVE:To sustain the release ofpaliperidone in *** Oil suspensions were prepared by mixing drugs with oil under vigorous vortex *** investigate the effects of different factors,such as particle size,suspension medium,drug loading and dosage volume,on in vitro *** vitro release studies of paliperidone oil suspension were performed in dialysis bags in wide neck flasks with 200ml of PBS (pH 7.4) at 37℃ in water bath *** was withdrawn for analysis by HPLC at predetermined time *** The optimal patch was acquired with drug loading of 6mg/ml,and dosage volume of *** oil gave a slower drug release at early stage and higher release degree than sesame *** size had no significant effect on in vitro release within a certain *** One simple preparation method for paliperidone oil suspension was established with steady in vitro release behavior for a week.

关键词： paliperidone schizophrenia oil suspension sustained release

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Novel pH and temperature dual-sensitive liposome gel based on mPEG-Hz-CHEMS cleavable polymer for vaginal delivery system

Novel pH and temperature dual-sensitive liposome gel based o...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Daquan Chen Kaoxiang Sun Hongjie Mu Yan Shen Qineng Ping Aiping Wang Rongcai Liang Wanhui Liu School of Pharmacy Yantai UniversityYantaiPeople's Republic of China State Key Laboratory of Longacting and Targeting Drug Delivery System YantaiPeople's Republic of China College of Pharmacy China Pharmaceutical UniversityNanjingPeople's Republic of China

In this study,a pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymer has been applied to vaginal administration for gynecological *** pH-sensitive cleavable mPEG-Hz-CHEMS was designed as a modified pH-sensitive liposome that would selectively degrade under locally acidic vaginal physiological *** novel pH-sensitive liposome was engineered to form thermogels at body temperature and degrade in an acidic environment.

关键词： mPEG-Hz-CHEMS polymer pH-sensitive liposomes thermosensitive liposome gel vaginal delivery

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Study on tumor-targeted delivery of anticancer agent using polyethylene glycol derivatives as drug carriers

Study on tumor-targeted delivery of anticancer agent using p...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Zhen Liang,Tao Gong,Xun Sun,Zhirong Zhang~* Key Laboratory of Drug Targeting and Drug Delivery Systems,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu,Peoples Republic of China

Cancer is one of the main causes leading to death,which seriously endangers human health and *** chemotherapy relies on cytotoxic drugs to kill rapidly proliferated cancer cells as much as ***,since most of the cytotoxic drugs are non-specific,they could kill normal cells along with tumor cells,which causes severely damages to normal tissues and a variety of adverse effects,accordingly reduces the life quality of *** addition,the therapeutic effect of conventional chemotherapy against solid tumors,which account for more than 90%of cancer currently,is far away from validity.

关键词： polyethylene glycol derivatives 5-fluorouracil polymeric carriers macromolecular prodrugs tumor-targeted drug delivery system

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