检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

590 篇 会议
2 篇 期刊文献

馆藏范围

592 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

395 篇 医学
- 314 篇 中西医结合
- 299 篇 药学(可授医学、理...
- 49 篇 临床医学
- 26 篇 中药学(可授医学、...
- 8 篇 公共卫生与预防医...
- 6 篇 中医学
- 5 篇 基础医学(可授医学...
- 3 篇 医学技术（可授医学...
12 篇 工学
- 10 篇 材料科学与工程（可...
- 1 篇 化学工程与技术
- 1 篇 环境科学与工程（可...
8 篇 理学
- 8 篇 物理学
8 篇 管理学
- 7 篇 公共管理
- 1 篇 工商管理
2 篇 经济学
- 2 篇 应用经济学
2 篇 农学
- 1 篇 作物学
- 1 篇 兽医学

主题

16 篇 doxorubicin
16 篇 nanoparticles
14 篇 nanoparticle
12 篇 paclitaxel
12 篇 chitosan
11 篇 delivery
11 篇 sirna
11 篇 polymeric micell...
10 篇 bioavailability
10 篇 cytotoxicity
10 篇 presentation
10 篇 liposomes
9 篇 hyaluronic acid
9 篇 pharmacokinetics
9 篇 drug
8 篇 drug delivery
8 篇 multidrug resist...
8 篇 sustained releas...
8 篇 p-glycoprotein
8 篇 ph-sensitive

机构

8 篇 college of pharm...
6 篇 national recogni...
5 篇 school of pharma...
5 篇 department of ph...
4 篇 national key lab...
4 篇 苏州大学
4 篇 中山大学
3 篇 兰州大学第一医院
3 篇 华中科技大学
3 篇 四川省中医药科学...
3 篇 school of pharma...
3 篇 河南省南阳纺织集...
3 篇 北大药学院
3 篇 department of ma...
3 篇 四川大学
3 篇 college of pharm...
3 篇 中国药学会
3 篇 浙江大学
3 篇 中科院生物物理研...
3 篇 pharmaceutics fa...

作者

11 篇 李范珠
8 篇 zhirong zhang
7 篇 jianping zhou
7 篇 zhenzhong zhang
6 篇 yan ma
6 篇 qiang zheng
6 篇 xiao ke
5 篇 xun sun
5 篇 hong yuan
5 篇 wei wu
5 篇 徐汉友
5 篇 weiyue lu
4 篇 tao gong
4 篇 fu-qiang hu
4 篇 yong-zhong du
4 篇 jinjin shi
4 篇 jian-qing gao
4 篇 wanhui liu
4 篇 郭哲宁
4 篇 honghong wang

语言

533 篇 英文
58 篇 中文
1 篇 法文

检索条件"任意字段=2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会"

共 592 条记录，以下是551-560 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-paclitaxel conjugate:Synthesis,characterization,and antitumor activity

Somatostatin receptor-mediated tumor-targeting drug delivery...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Meirong Huo.Qinnv Zhu,Yao Liu,Jianping Zhou~* Department of Pharmaceutics,China Pharmaceutical University,No.24 Tongjiaxiang,Nanjing 210009,China

Aims:A novel ligand-PEG-drug conjugate,octreotide-polyethene glycol-paclitaxel(OCT-PEG-PTX)was developed for efficient cancer ***:The ligand OCT was first conjugated to the carboxyl group of PEG by EDC reaction(OCT-PEG) and then the paclitaxel was conjugated to OCT-PEG by using succinic anhydride as a spacer(OCT-PEG-PTX).Non-targeted prodrug, PEG-PTX,was also synthesized as *** chemical structures and physicochemical properties were characterized indetail. Using NCI-H446 cells(SSTRs overexpression)and WI-38 cells(no SSTRs expression)as models,the cytotoxicity,drug intracellular biodistribution and cell apoptosis of OCT-PEG-PTX and PEG-PTX were ***,the in vivo anti-tumor efficacy of OCT-PEG-PTX was compared to PEG-PTX using NCI-H446 xenografted BALB/c nude ***:Both of OCT-PEG-PTX and PEG-PTX conjugates were successfully synthesized and the chemical structure was confirmed by TLC,'H-NMR and *** drug content of OCT-PEG-PTX and PEG-PTX was 12.0%and 14.0%respectively,and the solubility of PTX was up to 6.0 mg/mL and 9.4 mg/mL,*** release profile of PTX from both conjugates exhibited pH-sensitive *** with PEG-PTX, OCT-PEG-PTX exhibited significantly stronger cytotoxicity to NCI-H446 cells but with hardly any difference from WI-38 *** results of flow cytometry and confocal laser scanning microscopy further revealed that OCT-PEG-PTX could be selectively taken into tumor cells by SSTRs mediated *** vivo investigation of prodrugs on nude mice bearing NCI-H446 cancer xenografts confirmed that OCT-PEG-PTX possessed much higher tumor-targeting capacity than PEG-PTX control and exhibited enhanced anti-tumor efficacy and decreased systemic ***:These results suggest that OCT-PEG-PTX might be a promising anti-cancer drug delivery system for targeted cancer therapy.

关键词： octreotide somatostatin receptors prodrug polyethene glycol pacliatxel tumor targeting

来源：评论

学校读者我要写书评

暂无评论

A MSLN targeted multifunctional nano-immunoliposome for MR imaging and targeting therapy in pancreatic cancer

A MSLN targeted multifunctional nano-immunoliposome for MR i...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Li Deng~a,Xingfa Ke~a,Zhiying He~b,Jianming Chen~a a Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China b Department of Cell Biology,Second Military Medical University,Shanghai 200433,China

Aim:To provide a novel early diagnostic method and targeted therapy for pancreatic ***:a multifunctional nano-immunoliposome with high loading of ultrasmall superparamagnetic iron oxides（USPIOs）and doxorubicin（DOX）was prepared by transient binding and reverse phase evaporation（REV）method,and was conjugated with anti-mesothelin（MSLN） antibody by post insertion method to target mesothelin over expressed pancreatic cancer *** in vitro and in vivo properties of this anti-mesothelin antibody conjugated PEGlyated liposomal DOX and USPIOs（referred to as M-PLDU;the PEGlyated nanoimmunoliposome without antibody conjugation was referred to as PLDU）were evaluated both in human pancreatic cancer cell line Panc-1 cell and in a pancreatic cancer xenograft animal ***:M-PLDUs were spherical and uniform with a diameter about～180nm,the zeta potential about-28～-30 mV,and had good efficacy of encapsulating DOX and *** in vitro study demonstrated that M-PLDUs possessed good MR imaging capability with the transverse relaxivity（r2）about 58.5 Mm·s. Confocal microscopy showed more efficient uptake of M-PLDU in panc-1 cells by antibody mediated *** assay results showed significant inhibitory effect of M-PLDU against Panc-1 cells（IC50:1.95μM）.The in vivo imaging study showed that the tumor signal intensity（SI）dropped significantly about 4 h after intravenous injection of *** decrease in tumor SI induced by M-PLDUs（ASI=145.98±20.45）or PLDUs（ASI=75.69±14.53）was much more significant than that by free USPIOs （ASI=42.78±22.12,P < 0.01）.The in vivo antitumor study demonstrated that compared with FD（free doxorubicin）and PLDU, M-PLDU possessed higher inhibitory effect on tumor growth and the tissue distribution assay further proved that M-PLDUs could selectively accumulate in the tumor ***:These results indicated that M-PLDU not only well retained the inherent MR imaging capability of USPIOs but significantly improved the targeting

关键词： theranostic nanomedicine nanoimmunoliposome Mesothelin USPIO doxorubicin pancreatic cancer

来源：评论

学校读者我要写书评

暂无评论

Preparation and Evaluation of GP-2 Loaded Niosomes

Preparation and Evaluation of GP-2 Loaded Niosomes

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Zhengquan zhang,Hua zheng,Zhenzhong zhang Nanodrug research center.pharmaceutical school of Zhengzhou University,Zhengzhou,China

Objective:GP-2 is a semi-synthesized new compound using a lead compounds that originated from the active ingredient of Rabdosia *** pharmacological evaluation indicated that GP-2 have good anti-tumor activity,especially to esophageal, cardiac and liver cancers,and toxicological study show GP-2 have low ***-2 have poorly solubility in water and poor stability in gastrointestinal tissue,so a safe and effective non-parenteral route of administration is a key to GP-2 clinical application. Niosomes is a novel drug delivery system based on micro particles,a coupling form of amphiphilic molecules,and a structure of sphere or spheroid and one or multi compartment models made up of two enclosed layers of ***:In this study,the film dispersion-ultrasound method was adopted to prepare the GP-2 ***:GP-2 niosome have a entrapment efficiency of 72.6%±0.78%（WAV）,and an exterior of a light blue opalescent suspension（see figuer 1）,and the average particle size and distribution of 66.16±1.97nm and 0.150±0.002（see figuer 2）.Analyzed by differential scanning calorimetry（DSC）,the drugs exist in the state of amorphous in the *** vitro release suggested that the drug release was in accordance with the Higuchi release *** efficiency of niosomes could avoid the rapid degradation of the drug in the liver tissues in vitro and improve its stability. The pharmacodynamic evaluation of GP-2 niosomes towards EC9706 and 4T1 cells indicated that the preparation held significant inhibition toward both cells,to rhe esophageal cancer cell lines EC9706 the ICinhibitory concentration are 10.53,4.19,2.62umol respectively at 9.89,5.23,3.23umol respectively at 24h,48h,48h,both cell lines shows fine time-dependent characteristic;GP-2 niosome also demonstrated better inhibition efficiency to both cell lines than DMSO solution of GP-2,and dose-depentent characterestic（see figuer 3,4）.Conclusions:GP-2 niosome can solve GP-2 poor soluble problem,and possib

关键词： GP-2 niosomes degradation in vitro cell pharmacodynamics

来源：评论

学校读者我要写书评

暂无评论

Characteristics of sequential targeting to brain glioma for transferrin-modified cisplatin liposome

Characteristics of sequential targeting to brain glioma for ...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Qing Lv~(1,2),Min Han~1,Fan-Zhu Li~2,Jian-Oing Gao~(1*) 1 institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China 2 College of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 310053,China.

Objective:Methods on how to improve the sequential targeting of glioma subsequent to passing of drug through the blood-brain barrier(BBB)have been occasionally ***,the characteristics involved are poorly *** prepared a cisplatin loaded liposomal carrier modified with transferrin(Tf),expecting it to transport through BBB and sequential target C6 glioma cells, and the characteristics of "sequential-targeting" for lipsomes(Tf)were further studied. Methods:In the sequential-targeting liposomal carrier,cisplatin was incorporated into liposomes by reverse evaporation method and Tf was conjugated to the liposomes' *** cisplatin,cisplatin liposome and cisplatin liposome modified with Tf were applied to the apical compartment of the immortalized mouse brain endothelial cell line(bEnd3)/C6 co-culture models to screen the transport profile and investigate sequential targeting capacity to glioma after across *** characteristics of penetration into C6 tumor cells for liposomes after crossing BBB were explored via confocal *** sodium(FS)solution,sulforhodamine B(SRB)solution,FS loaded liposome labeled with SRB(FS-lipo-SRB),and FS loaded liposome modified with Tf labeled with SRB (FS-lipo(Tf)-SRB)were added into the apical compartment of the *** the competition experiments, Methyl-P-cyclodextrinp(Mβ-CD),chlorpromazine(CPZ)and free Tf were added 30 min in *** of drug(or fluorescent dye)and fluorescent labeling-liposome in C6 glioma cells after they transported across BBB with various inhibitors were added in advance as observed via laser scanning confocal microscopy. Results:In bEnd3/C6 co-culture BBB models,higher transport efficiency across the BBB and cytotoxicity in basal C6 cells induced by cisplatin liposome modified with Tf than cisplatin liposome and cisplatin solution,demonstrating that the cisplatin liposome modified with Tf exhibited a potent "sequential-targeting effect",transporting across th

关键词： sequential-targeting brain-targeted delivery transferring cisplatin glioma

来源：评论

学校读者我要写书评

暂无评论

Non-ionic surfactant vesicles simultaneously enhances the anti-tumor activitiy and reduces the toxicity of cantharidin

Non-ionic surfactant vesicles simultaneously enhances the an...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Hui Li~1,Meiwan Chen~2,Shengpeng Wang~2,Yitao Wang~(1,2*) 1 Institute of Chinese Materia Medica,Chinese Academy of Chinese Medical Sciences,100700,China 2 State Key Laboratory of Quality Research in Chinese Medicine(University of Macau),Institute of Chinese Medical Sciences, University of Macau,999078,China

The objective of the present study was to prepare cantharidin entrapped non-ionic surfactant vesicle(noisome)and evaluate the potential in enhancing the in vitro and in vivo anti-tumor activities and reducing *** loaded non-ionic surfactant vesicles(C-NSVs)were prepared by injection *** C-NSVs showed stable particle size at 209.8±0.5 nm,well drug entrapment efficiency(EE)and relative long-term physical *** treatment of mice with C-NSVs indicated a significantly decrease of acute toxicity and liver toxicity than cantharidin solution,which was associated with the down-regulation of serum glutamic-pyruvic transaminase(ALT),glutamic oxalacetic transaminase(AST),and total *** assay and flow cytometric analysis showed that C-NSVs could significantly enhance the in vitro cytotoxicity against human breast cancer cell line MCF-7 and induce more significant cell cycle arrest effect at G1 ***,Hoechst 33342 staining also implicated that C-NSVs induced higher apoptotic rates in MCF-7 cells than bulk cantharidin *** result of Senear mice treated with the same concentration of 1.0 mg/kg cantharidin also demonstrated that the tumor inhibition with C-NSVs(52.76%)is higher than cantharidin solution(31.05%).Our data revealed that NSVs would be a promising delivery system for enhancing the anti-tumor activity and reducing the toxicity of cantharidin simultaneously.

关键词： cantharidin non-ionic surfactant vesicle toxicity anti-tumor activity

来源：评论

学校读者我要写书评

暂无评论

Enhanced intestinal absorption of etoposide from Self-microemulsifying drug delivery system in rats:Roles of intestinal lymphatic transport and P-glycoprotein inhibition

Enhanced intestinal absorption of etoposide from Self-microe...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Jiangeng Huang,Gang Zhao,Luqin Si,Gao Li~* School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Objective:To improve the intestinal absorption of etoposide,a self-microemulsifying drug delivery system（SMEDDS）employing Polysorbate 80 as a surfactant was *** second aim of this study was to further investigate the role of intestinal lymphatic transport and P-glycoprotein efflux in rat intestinal absorption of etoposide. Methods:Etoposide SMEDDS were prepared based on the compositions of ethyl oleate:Polysorbate 80:polyethylene glycol 400 （1:2:1,w/w/w）.Either etoposide SMEDDS（1%,w/w）,etoposide with Polysorbate 80（1:50,w/w）,or etoposide suspension in 0.5% sodium carboxymethyl cellulose solution,was orally administered to the rats at a 12 mg/kg etoposide *** samples（0.2 ml） were obtained from tail vein at predetermined time ***,in situ single-pass intestinal perfusion with mesenteric vein cannulation was performed through ileum segment in *** final concentration of etoposide in all perfusate was 40μg/*** addition,uptake experiments of etoposide SMEDDS on P-gp expressing Caco-2 cells and non-P-gp expressing MCF-7 cells were also *** concentrations were measured using an ultra-performance liquid chromatography system equipped with an Agilent 6460 triple-quadrupole mass spectrometer. Results:Following 1:100 dilution of etoposide SMEDDS with blank HBSS,the droplet size and zeta potential value of microemulsion were（14.6±2.6）run and（-11.9±0.6）mV,*** Cfor oral administration of etoposide SMEDDS in rats intraperitoneally pretreated with cycloheximide or normal saline both significantly increased compared with those from etoposide suspension dosing（Figure 1）.As expected,the bioavailability of etoposide SMEDDS was evidently decreased by cycloheximide,an effective lymphatic transport blocker（Table 1）.The results of in situ single-pass intestinal perfusion experiments showed that the permeability of etoposide SMEDDS was increased by 3.9-fold for Pand 2.4-fold for P（Figure 2）.The uptake rates of etoposide SM

关键词： Etoposide Self-microemulsifying drug delivery system intestinal lymphatic transport P-glycoprotein

来源：评论

学校读者我要写书评

暂无评论

Preparation and evaluation of self-microemulsifying drug delivery systems(SMEDDS) containing Progesterone

Preparation and evaluation of self-microemulsifying drug del...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Mengjun Zhao,Yang Hu,Jiangeng Huang,Gao Li,Minghui Sun,Luqin Si~* School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Objective:Self-microemulsifying drug delivery system(SMEDDS)typically comprises a mixture of oil,surfactant,cosurfactant, and *** mixtures are expected to be self-emulsified in aqueous medium under gentle agitation and digestive motility in the gastrointestinal *** can be utilized for the design of formulations in order to improve the oral absorption of highly lipophilic drug *** is a poorly water soluble steroid hormone drug with relatively low oral *** main purpose of present work was to develop new self-microemulsifying drug delivery systems(SMEDDS)of Progesterone and assess its in vitro characteristics and in vivo intestinal absorption properties. Method:Suitable vehicles including oil,surfactant,cosurfactant were screened based on the solubility of *** surfactants were selected according to their emulsifying ability and compatibility with different *** phase diagrams were constructed to identify the efficient self-microemulsifying region and to screen optimal *** optimization of the formulation was performed by the central composite design-response surface method(CCD-RSM).Droplet size,zeta-potential and stability of the optimized formulations were ***,the in vitro release profiles of progesterone from SMEDDS,crude drug power and the conventional capsule in HC1(pH 1.2)and phosphate buffer(pH 7.4)were compared using the dialysis bag *** intestinal absorption properties of SMEDDS of progesterone were assessed using in situ single-pass intestinal perfusion technique. Results:The optimal composition of the progesterone SMEDDS formulation,with approximately 25 mg/g drug loading of progesterone,was oil(medium chain triglycerides(MCT),25%w/w),surfactant(Cremopher EL,50%w/w),and(propylene glycol, 25%w/w).The average droplet size of progesterone SMEDDS was less than 30 *** release rate of progesterone from SMEDDS was significantly higher than that from

关键词： Progesterone Self-microemulsifying drug delivery system central composite design-response surface method single-pass intestinal perfusion intestinal absorption

来源：评论

学校读者我要写书评

暂无评论

Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization

Enhanced dissolution and oral bioavailability of aripiprazol...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Yin Xu~(a,b),Mingzhu Shangguan.Xiaoyi Liu~c,Ruyue Lian~a,Siyi Zheng~c,Zongning Yin~b,Yi Lu~(a,*),Wei Wu~(a,*) a School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA,Shanghai, 201203,PR China b West China School of Pharmacy,Sichuan University,Chengdu,610041,PR China c Shanghai Zhong Xi Pharmaceutical(Group)Co.,Ltd.,Shanghai,200065,PR China

Reducing the particle size of drugs to produce nanosuspensions or nanocrystals,is quite advantageous for poorly soluble drugs to enhance their *** to the deficiency of conventional nanoprecipitation techniques,it is desired to explore relatively mild procedures to produce robust nanosuspensions. In this study,aripiprazole(APZ),a weak alkaline drug with pH-dependent solubility,was selected as model drug to examine the feasibility of preparing nanosuspensions using nanoprecipitation/homogenization technique based on acid-base *** related substances in nanosuspensions prepared by optimal conditions were *** effects of stabilizer concentration,drug concentration,homogenization pressure and cycles on the particle size and polydispersion index(PI)of nanosuspensions were studied,*** morphology of crystals were observated by *** solubility of APZ nanocrystals was compared with that of APZ raw material and physical mixture of APZ and stabilizers in different *** dissolution profiles for APZ raw material,physical mixture,nanosuspensions and market tablet in pH 1.2 and pH 4.0 buffered solutions were *** scanning calorimetry and powder X-ray diffractometry were used to confirm the crystallinity of APZ in *** oral bioavailability of the APZ nanosuspensions was studied using six male beagle dogs. The related substances in nanosuspensions prepared by optimal conditions were slightly increased as compared with APZ raw *** optimal conditions of stabilizer concentration,drug concentration,homogenization pressure and cycles were set as 0.5%,0.5%(each in 0.25%),1000 bar and 10 cycles *** resultant APZ nanosuspensions got a mean particle size of 350 nm with polydispersion index(PI)value of 0.20 and kept stable for 40 *** observation showed the morphology of oval crystals with rough *** significantly increased the solubility as well as the disso

关键词： nanosuspensions acid-base neutralization aripiprazole solubility dissolution oral bioavailability

来源：评论

学校读者我要写书评

暂无评论

The multifunctional nanoscaled delivery system for codelivery of nucleic acids and chemotherapeutics

The multifunctional nanoscaled delivery system for codeliver...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Na Zhang Department of Pharmaceutics,School of Pharmaceutical Science,Shandong University,44 West culture Road,Ji'nan 250012, Shandong Province,China

Codelivery of different therapeutics has a potential to efficaciously treat human diseases via their synergetic effects. Activable therapeutic tools at the nanoscale are suitable platforms for codelivery of different therapeutics,including nucleic acids and *** have recently developed a multifunctional nanoscaled delivery system simultaneously applied with tumor-targeted,pH-triggered and codelivery *** this study,DOX-HZN-PEI-PEG-TAT was first synthesized and complexed with pDNA to form DOX Ioaded-TAT modified polyion complex micelles(PIC).Next,sulfamerazine(SA)-PEG-NGR(SA, pKa=7.0)was synthesized and attracted on the surface of PIC to obtain NGR modified PIC micelles(targeted PIC micelles,TPIC). SA is weakly acidic due to the readily ionizable hydrogen atom in the amide bond in *** the pKa,SA has a negative charge, while it is neutral below the ***,at physiological pH(pH=7.4),the TPIC could be constructed by the electrostatic interaction between the positive charged core of PIC and negatively ***,the steric hindrance created by the long PEG spacer was expected to shield the surface-attached TAT to reduce its associated side effects on normal ***,at tumour site (pH<7.0),SA-PEG-NGR could be dissociated from the surface of PIC and TAT was exposed to facilitate the tumour cellular uptake (Fig.1). The resultant DOX-HZN-PEI-PEG-TAT conjugates had a drug loading of 8.01±1.22%.The results of in vitro DOX release confirmed that the DOX release via pH-dependent hydrolysis of the hydrazone bond,which showed lower release rate at pH7.4 and higher rate pH *** addition,DOX-HZN-PEI-PEG-TAT exhibited higher cell cytotoxicity at pH 5.0 than pH 7.4(p<0.05)and higher fluorescence intensity in cells at pH 5.0 was shown than that at pH *** obtained PIC and TPIC displayed nearly spherical shape and no aggregation was *** sizes were 187.6±4.3nm and 221.2±6.8nm,*** zeta potentials were 20.5±2.4mV an

关键词： Codelivery multifunctional nanoscaled delivery system doxorubicin gene delivery polyion complex micelles

来源：评论

学校读者我要写书评

暂无评论

Preparation of SLN Enriched Hydrogel for Topical Delivery of Astragaloside IV and Its Influence on Wound Healing and Scar Inhibition

Preparation of SLN Enriched Hydrogel for Topical Delivery of...

引用

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Xi Chen,Li-Hua Peng,Ying-hui Shan,Ni Li,Jian-Oing Gap~* Department of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,China

Aim of the study:This study was to investigate the novel preparation of the solid lipid nanoparticle-enriched hydrogel(SLN-gel)for the topical delivery of astragalosideⅣ,as well as to study the influence of astragalosideⅣbased SLN-gel on wound healing and scar formation. Materials and methods:Solid lipid nanoparticle(SLN)was prepared by solvent evaporation method with glycerol tristearate and poloxamer 188 as lipid phase and surfactant,*** particle size,polydispersity index(PDI),zeta potential(ZP), encapsulation efficiency(EE),drug release and morphological properties were *** optimized SLN was incorporated in carbomer hydrogel to form the SLN enriched gel(SLN-gel)*** influence of the astragalosideⅣincorporated SLN in the wound scratch test and its uptake by skin cells were tested in *** the rat full-skin excision model,the in vivo regulation of astragalosideⅣbased SLN-gel in the wound stages of re-epithelization,angiogenesis and extracellular matrix remodeling were investigated. Results:The best formulation of astragalosideⅣbased SLN had outstanding EE(93±5%),high ZP(-23.6±1.5),low PDI(0.18±0.03) and high drug loading of 9%.For astragalosideⅣbased SLN-gel,the final concentration of astragalosideⅣwas 0.5mg per 1g ***Ⅳbased SLN or SLN-gel could release drug in a sustainable *** vitro,astragalosideⅣbased SLN could enhance the migration and proliferation of keratinocytes and increase drug uptake on fibroblasts(P<0.01)with the caveolae endocytosis pathway,which was inhibited by methyl-p-cyclodextrin(MβCD).In vivo,astragalosideⅣbased SLN-gel could strengthen the wound healing and inhibit scars formation with the mechanisms:1)increasing wound closure rate(P<0.05);2) contributing to angiogenesis and collagen regular *** was demonstrated that the structure of regenerated skins treated by astragalosideⅣbased SLN-gel was similar to that of normal skin with many blood vessels,regular collagen deposition

关键词： solid lipid nanoparticle enriched hydrogel wound healing scar inhibition

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共60页 << < 51 52 53 54 55 56 57 58 59 60 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：