Purpose A subcutaneous exenatide delivery system was developed to achieve sustained release via mesoporous silicon *** Exenatide was loaded into mesoporous silicon *** vitro, EXT@SBA-15 release was investigated by ***...
Purpose A subcutaneous exenatide delivery system was developed to achieve sustained release via mesoporous silicon *** Exenatide was loaded into mesoporous silicon *** vitro, EXT@SBA-15 release was investigated by *** vivo, EXT plasma concentrations were analyzed after delivery in *** they were determined using the exendin-4 *** use diabetic mice to monitor blood glucose.
Development of safe and efficient small interfering RNA (siRNA) delivery systems still remains elusive in clinical applications of siRNA for cancer treatment.[1] An ideal siRNA delivery system is required to be stable...
Development of safe and efficient small interfering RNA (siRNA) delivery systems still remains elusive in clinical applications of siRNA for cancer treatment.[1] An ideal siRNA delivery system is required to be stable in the blood for preferential tumor targeting and overcome a variety of physiological barriers followed by efficient intracellular siRNA release for enhanced therapeutic efficacy.
Mesoporous silica nanoparticles (MSNs) are new material system at the end of 20th *** have unique properties such as large surface area(~1000 m2g-1),large pore volume (~1cm3g-1) ,controllable pore size (2~50 nm), very...
Mesoporous silica nanoparticles (MSNs) are new material system at the end of 20th *** have unique properties such as large surface area(~1000 m2g-1),large pore volume (~1cm3g-1) ,controllable pore size (2~50 nm), very narrow particle size distribution and open pore ***, MSNs are widely used in the field of drug delivery system, protein separation, adsorption, molecular sieving and catalysis.
The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past *** acid labile hydrazine bonds were formed by conjugating DOX onto side *** other drugs such as Paclitaxel (PT...
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The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past *** acid labile hydrazine bonds were formed by conjugating DOX onto side *** other drugs such as Paclitaxel (PTX) and cisplatin are not applicable for the lack of special functional *** this study, diblock copolymers, poly(ethylene glycol)-hydrazone-poly (lactic acid) (PEG-Hz-PLA) containing pH-responsive hydrazone bond between hydrophilic and hydrophobic segments were synthesized.
Inhibiting tumor-associated angiogenesis is a validated major strategy in cancer *** drug targets desired to be excavated for the poor response and resistance of the early antiangiogenic ***, Dll4-Notch signaling path...
Inhibiting tumor-associated angiogenesis is a validated major strategy in cancer *** drug targets desired to be excavated for the poor response and resistance of the early antiangiogenic ***, Dll4-Notch signaling pathway has emerged as a critical regulator of the development and maintenance of tumor ***-like ligand 4 (Dl14), the only Notch ligand to be selectively over-expressed on endothelial cells, is involved in tumor ***, Dll4 is a negative-feedback regulator of angiogenesis and strongly upregulated in tumor vasculature.
The OX26-PEG-CSLN was prepared by the emulsion evaporation-solidification at low temperature method and mercaptan modification *** average particle size of OXe26-PEG-CSLN was 47.68±1.65 nm and the zeta potent...
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The OX26-PEG-CSLN was prepared by the emulsion evaporation-solidification at low temperature method and mercaptan modification *** average particle size of OXe26-PEG-CSLN was 47.68±1.65 nm and the zeta potential was-0.533±0.115 mV.
The applications of superparamagnetic iron oxide nanoparticles (SPIONs), especially in the biomedical field, is rapidly increasing for tumor diagnosis and ***, two problems are common confronted when applying these pa...
The applications of superparamagnetic iron oxide nanoparticles (SPIONs), especially in the biomedical field, is rapidly increasing for tumor diagnosis and ***, two problems are common confronted when applying these particles in vivo: (1) conventional SPIONs have severely nonspecific uptake by non-target cells under the action of an external magnetic field, which weakens the targeting efficiency of SPIONs;(2) at size less than 15 nm, the particles have very limited drug-loading capacity which undermines the curative effect severely.
RNA interference (RNAi) is emerging as one of promising strategies for tumor therapy, especially for inhibiting tumor ***, an efficient and safety non-virus delivery system for clinical siRNA therapy is still a major ...
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RNA interference (RNAi) is emerging as one of promising strategies for tumor therapy, especially for inhibiting tumor ***, an efficient and safety non-virus delivery system for clinical siRNA therapy is still a major *** applications of cationic non-viral vectors are limited because of their low transfection efficiency, especially in the serum containing mediums and in vivo *** difficulty of lysosome escape and nonspecific adsorption of serum proteins are considered the main *** this talk, I'd like to introduce several recent approaches developed by our group to overcome these barriers for siRNA delivery.
Objective: In the past few years, aptamer physisorbed on graphene oxide (GO) has emerged as a useful sensing platform In a typical assay, a fluorescently labeled aptamer probe is adsorbed by GO and the target analyte ...
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Objective: In the past few years, aptamer physisorbed on graphene oxide (GO) has emerged as a useful sensing platform In a typical assay, a fluorescently labeled aptamer probe is adsorbed by GO and the target analyte induces probe desorption and fluorescence ***, in these systems, some non-target analytes can also desorption the physisorbed *** address the non-specific displacement, we herein report a covalent linked aptamer probe for ATP detection (Figure 1).
Sustained and controlled release formulations which is local injection administered once a few weeks or months has been highly concerned by a great number of pharmaceutical researchers and companies, especially import...
Sustained and controlled release formulations which is local injection administered once a few weeks or months has been highly concerned by a great number of pharmaceutical researchers and companies, especially important for long-term medication diseases as cancer, diabetes, mental illness and neurodegenerative *** drug delivery system has several advantages: 1) Injected directly into the lesion, reduce adverse reactions and increase the therapeutic effect;2) Reduce the frequency of administration and improve patient compliance significantly;3) Control the drug sustained release in several weeks or months which could make the drug plasma concentration flatten, reduce drug plasma concentration fluctuations by administered conventional formulations repeatedly and improve the safety and effectiveness of drugs;4) From the point of view of pharmacoeconomics, it can significantly reduce treatment costs and improve value.5) Further patent applications, help manufacturers to extend the life of the drug market.
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