Objective:The aim of this study was to assess the potential of vinpocetine loaded micelles fabricated from mPEG-PLA as a sustained release system and its pharmacokinetics in ***:Three micelle fabrication methods were ...
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Objective:The aim of this study was to assess the potential of vinpocetine loaded micelles fabricated from mPEG-PLA as a sustained release system and its pharmacokinetics in ***:Three micelle fabrication methods were examined to maximize vinpocetine loading,followed by structurally characterized and investigation of in vitro release and in vivo pharmacokinetics in Sprague-Dawley *** pharmacokinetic parameters of vinpocetine in micelle formulation were compared to its clinical formulation.
Multidrug resistance (MDR) in cancer is a major cause for the failure of anti-cancer chemotherapy with elevated expression of particular proteins,such as glycoprotein P (P-gp).It was found that some Pluronics could in...
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Multidrug resistance (MDR) in cancer is a major cause for the failure of anti-cancer chemotherapy with elevated expression of particular proteins,such as glycoprotein P (P-gp).It was found that some Pluronics could inhibit the P-gp efflux system,resulting in drastic sensitization of these tumors with respect to anticancer agents.
Aim:Study on the effect of miRNAs targeted delivery system to prostate ***:This study designed polyamidoamine (PAMAM) nanoparticle as drug carriers,miR-15a/miR-16-1 as model drug,aptamer (A10-3.2) as prostate-targetin...
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Aim:Study on the effect of miRNAs targeted delivery system to prostate ***:This study designed polyamidoamine (PAMAM) nanoparticle as drug carriers,miR-15a/miR-16-1 as model drug,aptamer (A10-3.2) as prostate-targeting ligand,prostate-specific membrane antigen (PSMA) as target,and all these co-constructed miRNAs targeted nanoparticle mediated by apta mer (PAMAM-PEG-A10/miRNA).
Liposomes are spherical vesicles consisting of lipid bilayers surrounding aqueous spaces,and drugs can be encapsulated in the phospholipid bilayer or the aqueous *** (Dox) is an effective and widely used chemotherapeu...
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Liposomes are spherical vesicles consisting of lipid bilayers surrounding aqueous spaces,and drugs can be encapsulated in the phospholipid bilayer or the aqueous *** (Dox) is an effective and widely used chemotherapeutic agent for cancer ***,tumor resistant to doxorubicin limited its further success in *** present,the resistance of cancer cells to multiple structurally unrelated chemotherapeutic drugs continues to be a major challenge in cancer treatment.
Objective:Solid lipid nanoparticle(SLN) with artemisinin was developed for pulmonary administration because of its poor water *** formula and preparation of artemisinin-loaded solid lipid nanoparticle(ART-SLN) were op...
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Objective:Solid lipid nanoparticle(SLN) with artemisinin was developed for pulmonary administration because of its poor water *** formula and preparation of artemisinin-loaded solid lipid nanoparticle(ART-SLN) were optimized and its characteristics of ART-SLN were also studied.
The article is to review the research process and application of amino acid fragments used as carrier in nanometer drug delivery *** poly-amino acid carrier is mainly applied as pH-sensitive carrier,micelles-forming c...
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The article is to review the research process and application of amino acid fragments used as carrier in nanometer drug delivery *** poly-amino acid carrier is mainly applied as pH-sensitive carrier,micelles-forming carrier and gene therapy ***-or temperature-sensitive carrier Water-soluble methoxy poly(ethylene glycol)-block-dendritic poly(1-lysine) MPEG-block-DPL4 with 4 generation PLL was synthesized by liquid-phase synthesis with well-defined structure.
Previous studies have demonstrated that nanostructured lipid carrier (NLC) is a promismg system for poorly water-soluble drugs delivery with improved *** NLC,however,is mostly prepared in a liquid form,which has some ...
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Previous studies have demonstrated that nanostructured lipid carrier (NLC) is a promismg system for poorly water-soluble drugs delivery with improved *** NLC,however,is mostly prepared in a liquid form,which has some disadvantages:drug expulsion during storage,thermodynamic instability and high water content of NLC ***,the conversion of the NLC suspension into a dry product is necessary.
Doxorubicin is one of the most promising chemotherapeutic agents for the treatment of androgen-independent prostate cancer,non-small-cell lung cancer and locally advanced or metastatic breast *** smart micelles are co...
Doxorubicin is one of the most promising chemotherapeutic agents for the treatment of androgen-independent prostate cancer,non-small-cell lung cancer and locally advanced or metastatic breast *** smart micelles are composed of four key components:(1) a chemotherapeutic agent doxorubicin (DOX);(2) a TAT peptide that can induce endocytosis for cell uptake;(3) a pH sensitive compound SA-SD which is loaded at the hydrophobic core of each micelle;(4) a biodegradable PEG-PE.
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