Objective:To prepare salmeterol xinafoate(SalX)-loaded nanoparticles-in-microparticles system(NiMS). Methods:SalX loaded nanoparticles was formed through ionotropic gelation process with biocompatible chitosan as the ...
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Objective:To prepare salmeterol xinafoate(SalX)-loaded nanoparticles-in-microparticles system(NiMS). Methods:SalX loaded nanoparticles was formed through ionotropic gelation process with biocompatible chitosan as the carrier *** a one step technique of spray drying was used to microencapsulate the colloidal nanoparticle suspension to form powdered NiMS *** morphology and surface appearance of the spray-dried NiMS were examined by scanning electron
作者：
Na ZhangDepartment of Pharmaceutics
School of Pharmaceutical ScienceShandong University44 West culture RoadJi'nan 250012Shandong ProvinceChina
Codelivery of different therapeutics has a potential to efficaciously treat human diseases via their synergetic *** therapeutic tools at the nanoscale are suitable platforms for codelivery of different therapeutics,in...
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Codelivery of different therapeutics has a potential to efficaciously treat human diseases via their synergetic *** therapeutic tools at the nanoscale are suitable platforms for codelivery of different therapeutics,including nucleic acids and *** have recently developed a multifunctional nanoscaled delivery system simultaneously applied with tumor-targeted,pH-triggered and eodelivery *** this study,DOX-HZN-PEI-PEG-TAT was first synthesized and complexed with pDNA to form DOX loaded-TAT modified polyion complex micelles (PIC).
Aim:To provide a novel early diagnostic method and targeted therapy for pancreatic ***:a multifunctional nano-immunoliposome with high loading of ultrasmall superparamagnetic iron oxides (USPIOs) and doxorubicin (DOX)...
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Aim:To provide a novel early diagnostic method and targeted therapy for pancreatic ***:a multifunctional nano-immunoliposome with high loading of ultrasmall superparamagnetic iron oxides (USPIOs) and doxorubicin (DOX) was prepared by transient binding and reverse phase evaporation(REV) method,and was conjugated with anti-mesothelin(MSLN) antibody by post insertion method to target mesothelin over expressed pancreatic cancer cells.
Glioma is the most abundant of all primary central nervous system(CNS) *** to the severity of the disease,glioma is graded from I(benign) to IV(highly malignant).And the low-grade tumors usually evolved into a high-gr...
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Glioma is the most abundant of all primary central nervous system(CNS) *** to the severity of the disease,glioma is graded from I(benign) to IV(highly malignant).And the low-grade tumors usually evolved into a high-grade glioblastoma ***,irrespective of their grading,primary glioma almost invariably display marked infiltrative growth characteristics with glial cells travelling long distances(centimeters) away from the central part into the surrounding normal brain ***,
Aim:Lactoferrin (Lf),a mammalian cationic iron-binding glycoprotein belonging to the transferrin(Tf) family,has been widely used in a number of areas from infant diarrhea and support for newborn growth to food and pha...
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Aim:Lactoferrin (Lf),a mammalian cationic iron-binding glycoprotein belonging to the transferrin(Tf) family,has been widely used in a number of areas from infant diarrhea and support for newborn growth to food and pharmaceutical *** this study,lactoferrin nanoparticles were used as carrier of gambogic acid (GA) to increased its solubility,oral absorption time and hence reduce its side effects.
The lancet reported in 2012 that kidney disease,as a leading public health problem,is highly prevalent in the *** prevalence of chronic kidney disease was 6.5-10%in developed countries,and was as high as 10.8%in China...
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The lancet reported in 2012 that kidney disease,as a leading public health problem,is highly prevalent in the *** prevalence of chronic kidney disease was 6.5-10%in developed countries,and was as high as 10.8%in China(The Lancet 379,2012:815-822).More seriously,90%of patients do not know they are suffering from kidney disease.
Porous silica nanoparticles (PSN) are universally addressed as a major candidate for use as carriers in controlled drug delivery ***,most templates used to prepare PSN are poisonous *** reduce the toxicity and improve...
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Porous silica nanoparticles (PSN) are universally addressed as a major candidate for use as carriers in controlled drug delivery ***,most templates used to prepare PSN are poisonous *** reduce the toxicity and improve stimulatory of surfactants,the surfaetant templates must be removed from the pore channel systems before drug molecules were loaded into PSN in the traditional preparing *** fact,there is no guarantee that the surfactants will be removed completely from the pore channel systems,and this loading method (drug loading after PSN formation) is far inferior to in situ loading (drug loading and PSN formation by one step) in drug loading ability.
Purpose:To evaluate intestinal retentive performance in vitro of Konjac Glucomannan superporous hydrogel(KGM-SPHH) as controlled-release vehicle for matrine,an anti-inflammatory agent. Methods:Both swelling and erosio...
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Purpose:To evaluate intestinal retentive performance in vitro of Konjac Glucomannan superporous hydrogel(KGM-SPHH) as controlled-release vehicle for matrine,an anti-inflammatory agent. Methods:Both swelling and erosion ratio of KGM-SPHH in different media were tested in a paddle device by gravitation method. Adhesion property of KGM-SPHH in intestinal tract of SD rats were studied by centrifuging the sample in a glass tube device for 5
Objective:DBH-1,which is a poorly water soluble drug,was prepared to DBH-1 emulsions with the droplet size of 160nm by the high pressure homogenization *** study was to assess the permeability and the safety of the DB...
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Objective:DBH-1,which is a poorly water soluble drug,was prepared to DBH-1 emulsions with the droplet size of 160nm by the high pressure homogenization *** study was to assess the permeability and the safety of the DBH-1 emulsions across Caco-2 cell monolayers. Methods;Caco-2 cells were seeded at a density of about 6.25×10～4 cells/cm on a 12 wells Transwell insert filter and left to grow 21
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