OBJECTIVE To study hemostatic and healing effect of the self-producing water-soluble O-carboxymethyl chitosan hemostatic *** With establishing a wounding model of vein and artery shearing of the Japanese large ear rab...
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OBJECTIVE To study hemostatic and healing effect of the self-producing water-soluble O-carboxymethyl chitosan hemostatic *** With establishing a wounding model of vein and artery shearing of the Japanese large ear rabbit,commercial absorbable-gelatin sponge was used as a positive control,medical gauze was used as a negative *** the hemostatic efficacies and reliability were compared between a self-producing sponge group and *** the same time,the wound healing effect of a self-producing sponge on a wounding model of scalpel shearing of the Japanese large ear rabbit was observed through both the histological sections observation and the size of wound *** The results showed that the self-producing sponge was significantly shorter than commercial absorbable-gelatin sponge on the bleeding time(P<0.01)and no recurring hemorrhage was found with reliable hemostatic *** taking care of the wound contraction,the self producing sponge group was much more quickly than that in control *** self producing sponge group was significantly better than that in control group of blood,redness,errhysis,itching,scab and incrustation,flatness,skin elasticity and so *** self producing sponge group was covered with epidermal on wound and divided clearly at the epidermis and *** wound healed get close to normal skin *** We consider that the self producing O-carboxymethyl chitosan hemostatic sponge has good hemostatic *** could promote the healing of bleeding wounds,*** has portable and easy to use and would has a widely future in wound hemostatic fields.
作者：
Tao YANGHuan-huan SHENGYan LIXue-mei CHENGZheng-tao WANGChang-hong WANGInstitute of Chinese Materia Medica
Shanghai University of Traditional Chinese MedicineThe MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesShanghai Key Laboratory of TCM Complex PrescriptionShanghai 201203China Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineThe MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesShanghai Key Laboratory of TCM Complex PrescriptionShanghai 201203China Department of Pharmaceutics
College of PharmacyXinjiang Medical UniversityUrumqi Xinjiang 830054China Department of PharmaceuticsCollege of PharmacyXinjiang Medical UniversityUrumqi Xinjiang 830054China
Objective:To establish a method for simultaneously determination of drug loading and entrapment efficiency of total lactones from Andrographis Paniculata loaded solid lipid nanoparticles (TLA-SLN),and to optimize the ...
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Objective:To establish a method for simultaneously determination of drug loading and entrapment efficiency of total lactones from Andrographis Paniculata loaded solid lipid nanoparticles (TLA-SLN),and to optimize the formula of ***:The free drugs in TLA-SLN were separated by ultrafiltration along with HPLC assay for AND、NEO、DEO and *** separation was performed on a Kromasil C18 column (150 mm × 4.6 mm,5μm) with mixture of acetonitrile-water (30 ∶ 70) as the mobile phase and with column temperature at 35 ℃.
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