Introduction Abnormal intracellular Ca handling can lead to the occurrence and maintenance of *** are voltage insensitive and are activated by intracellular *** pore-forming subunits of SK channels constitutively bind...
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Introduction Abnormal intracellular Ca handling can lead to the occurrence and maintenance of *** are voltage insensitive and are activated by intracellular *** pore-forming subunits of SK channels constitutively binds calmodulin that mediates Ca ***Ⅱactivity
Aim:Homocysteine（Hcy） is an independent risk factor of atherosclerosis through its involvement with the methionine *** this study,we aimed to determine the blood vessel global methylation rate in Hcy-induced atheros...
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Aim:Homocysteine（Hcy） is an independent risk factor of atherosclerosis through its involvement with the methionine *** this study,we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient(ApoE) mice,and to explore the
＜正＞Objectives Ang-（1-7） is generated from angiotensin 1（AngⅠ） and angiotensin 2（AngⅡ） under the catalysis of angiotensin converting enzyme（ACE） and angiotensin converting enzyme 2（ACE2）. Enhancing the e...
＜正＞Objectives Ang-（1-7） is generated from angiotensin 1（AngⅠ） and angiotensin 2（AngⅡ） under the catalysis of angiotensin converting enzyme（ACE） and angiotensin converting enzyme 2（ACE2）. Enhancing the effect of Ang-（1-7） to rebalance Ang-（1-7） and AngⅡis an effective strategy for treatment of *** aim of this study was to determine the role of ACE2/Ang-（1-7）/Mas
Aim Homocysteinemia(Hcy)is associated with Endothelial Progenitor Cells(EPCs) dysfunction, but the underlying mechanisms have not been thoroughly *** this study,we aimed to investigate the effect of elevated Hey on th...
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Aim Homocysteinemia(Hcy)is associated with Endothelial Progenitor Cells(EPCs) dysfunction, but the underlying mechanisms have not been thoroughly *** this study,we aimed to investigate the effect of elevated Hey on the EPCs dysfunction via Cyclin A DNA methylation and
Understanding intracellular signaling mechanisms underlying protective response against ischemic injury in cardiovascular system is one of major steps in the development of effective drugs for treating ischemic ***,we...
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Understanding intracellular signaling mechanisms underlying protective response against ischemic injury in cardiovascular system is one of major steps in the development of effective drugs for treating ischemic ***,we have demonstrated using endothelium-specific
Objective NCX exists in three isoforms:NCX1、NCX2、***1 are expressed abundantly in ***1 exports one Ca ion for the uptake of three Na ***1 extrudes calcium ion after contraction and helps the cardiomyocyte to ***1 pl...
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Objective NCX exists in three isoforms:NCX1、NCX2、***1 are expressed abundantly in ***1 exports one Ca ion for the uptake of three Na ***1 extrudes calcium ion after contraction and helps the cardiomyocyte to ***1 plays a crucial role in atrial
Hypoplastic left heart syndrome(HLHS) is a serious congenital cardiovascular malformation resulting in hypoplasia or atrcsia of the left ventricle,ascending aorta,aortic and mitral valves. Diminished flow through the ...
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Hypoplastic left heart syndrome(HLHS) is a serious congenital cardiovascular malformation resulting in hypoplasia or atrcsia of the left ventricle,ascending aorta,aortic and mitral valves. Diminished flow through the left side of the heart is clearly a key contributor to the condition,but
Aim:This study aimed at constructing a eukaryotic expression vector by fusing enhanced green fluorescent protein(EGFP) to different sites of transient outward potassium channel(Kv4.2), comparing the effect of differen...
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Aim:This study aimed at constructing a eukaryotic expression vector by fusing enhanced green fluorescent protein(EGFP) to different sites of transient outward potassium channel(Kv4.2), comparing the effect of different EGFP position on the electrophysiological characteristics and kinetics of the channel and finally analyzing the underlying ***:Kv4.2 protein
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