To investigate clinical characteristics and related factors of telbivudine-associated rhabdomyolysis (RM), we searched domestic and foreign medical literature databases as well as Beijing Adverse Drug Reaction Monitor...
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To investigate clinical characteristics and related factors of telbivudine-associated rhabdomyolysis (RM), we searched domestic and foreign medical literature databases as well as Beijing Adverse Drug Reaction Monitoring *** of telbivudine-associated RM were *** information of patients and situations of medications were *** of adverse drug reactions (ADRs), clinical manifestations, treatments and outcomes were investigated and *** reviewing 226 literatures and 41 reports, a total of 22 RM cases were *** the cases were male patients with an average age of 34.5±11.2 years, and all these patients had chronic hepatitis B and received telbivudine 600 mg/*** occurrence time of RM *** case occurred within 5 months (4.5%), 11 cases occurred within 6 to 10 months (50.0%), eight cases occurred within 11 to 15 months (31.8%), and three cases occurred after 15 months (13.6%).Clinical manifestations were mostly nausea, vomiting, palpitations,weakness and edema of the lower *** the telbivudine treatment was discontinued and symptomatic treatments were provided, 12 patients were clinically improved, four patients were physically impaired, two patients showed unknow results, and four deaths were ***, age (P =0.61), duration of medication (P =0.54) and CK value (P =0.07) were not statistically associated with *** are advised to monitor clinical manifestations in patients receiving *** on serum creatinine level is suggested if *** should be promptly discontinued, and symptomatic treatment should be given when ADRs occur.
Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial *** previous study found that CLP-19, a looped peptide derived from limulus anti-lipopolysacchari...
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Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial *** previous study found that CLP-19, a looped peptide derived from limulus anti-lipopolysaccharide peptide with high LPS-neutralizing activity,have showed immunoregulatory effect but the molecular mechanism is *** this study, Our results shows that CLP-19 significantly increased the survival rate in lethal LPS shock mouse models, decreased the serum TNF-α level and reduced the pathological injury of lung 20 h prior to LPS ***-19 also induced endotoxin tolerance (ET) phenotype in RAW 264.7 cells in vitro in a dose-dependent and time-dependent manner, which attenuated LPS-induced TNF-α and IL-6 secretion and increased anti-inflammatory factor, IL-10 *** by CLP-19,the expressions of Toll-like receptors 4 (TLR4) on the cell surface remarkably decreased by LPS ***, CLP-19 pretreatment inhibited degradation of inhibitor of nuclear factor (NF)-κB (I-κB) rather than influenced expression of myeloid differentation 88 (MyD88) and TIR domain-containing adapter inducing IFNγ 6 (TRIF6), resulting in decreased expression of inflammatory cytokine *** together with the finding suggested that CLP-19 induces ET phenotype via inhibiting NF-κB *** conclusion, we have revealed a novel function of CLP-19 that appears to represent a potential therapeutic agent for clinical treatment of sepsis.
汇报内容临床药学学习课程介绍英国临床药师的发展及工作内容心得体会回国后的工作方向University College London UCL, School of Pharmacy临床药学学习课程介绍□University College London, School of Pharmacy·建于1842年,是...
汇报内容临床药学学习课程介绍英国临床药师的发展及工作内容心得体会回国后的工作方向University College London UCL, School of Pharmacy临床药学学习课程介绍□University College London, School of Pharmacy·建于1842年,是英国评价最高的药学院之一,现为欧洲最大的生物医学研究中心.
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