Objectivs:To perform a meta-analysis exclusively including head-to-head randomized controlled trials(RCTs) that directly compared the fracture prevention efficacy and the safety between alendronate(Aln) and raloxifene...
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Objectivs:To perform a meta-analysis exclusively including head-to-head randomized controlled trials(RCTs) that directly compared the fracture prevention efficacy and the safety between alendronate(Aln) and raloxifene(Rlx) for postmenopausal women with osteoporosis,and comprehensively identify the potential influential *** sources:Electronic databases(Pubmed,Medline,Clinical Trial Registry,EMBASE and the Cochrane Data Base of Systematic Reviews,the Cochrane Central Register of Controlled Trials) were searched without limit up to September 2012 for relevant *** methods:Only RCTs containing both Aln and Rlx for treating postmenopausal women with osteoporosis,and assessing at least one of the following
Background:The impact of percutaneous internal fixation as a supplement to percutaneous kyphoplasty(PKP) for the management of the thoracolumbar burst fractures of the aged patients is *** conducted a clinical control...
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Background:The impact of percutaneous internal fixation as a supplement to percutaneous kyphoplasty(PKP) for the management of the thoracolumbar burst fractures of the aged patients is *** conducted a clinical controlled trial to define the effect of percutaneous internal fixation with PKP on thoracolumbar fractures and patientrelated functional outcomes. Method:This study included 43 patients with thoracolumbar burst fractures without nerve injuries who were elder than 65 years *** were randomly assigned to treatment with simple PKP(control group,n=22) and percutaneous short-segment pedicle screw internal fixation with PKP(treatment group,n=21).The patients were followed for at least two years postoperatively and were assessed with regard to clinical and radiological outcomes. Clinical outcomes were evaluated mainly with use of visual pain analog scale(VAS) and questionnaire score of Oswestry disability index(ODI).Radiological outcomes were assessed mainly on the basis of Cobb kyphosis angle and loss of kyphosis correction. Results:There was no significant difference between the two groups with regard to the preoperative indexes. The treatment group had better VAS values and had more postoperative improvements in ODI results as compared with the control group(P < 0.05).Postoperative kyphosis angle correction of the treatment group was superior to that of the control group,and postoperative correction loss was significant less compared with the control group(P < 0.05). In the control group,two patients postoperatively suffered refractures in the injured vertebra and one patient had refracture in the adjacent *** operation complications need managements were noted postoperatively in both groups. Conclusions:Compared with simple PKP operation,percutaneous internal fixation with PKP is one kind of more ideal surgical technique for the treatment of selected elderly thoracolumbar burst fractures.
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