Objective:The aim of this study was to perform a head-to-head comparison of efficacy and safety profile between 60 mg denosumab(Den) subcutaneously(SC) per 6 months(Q6M) and 70 mg alendronate(Aln) orally per week(QW) ...
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Objective:The aim of this study was to perform a head-to-head comparison of efficacy and safety profile between 60 mg denosumab(Den) subcutaneously(SC) per 6 months(Q6M) and 70 mg alendronate(Aln) orally per week(QW) for postmenopausal women with low bone mineral *** searched electronic databases comparing efficacy and safety of Den SC Q6M and Aln QW in postmenopausal *** primary outcomes of efficacy evaluation in included trials were incidence of clinical fracture in both groups and bone mineral density (BMD) at different skeletal *** adverse events(AEs),including incidence of neoplasms and infections,were considered as secondary *** the instructions of 'Cochrane Handbook for systematic Reviews of Interventions 5.0.2',we identified eligible studies,evaluated the methodological quality and abstracted relevant *** heterogeneous randomised controlled trials(RCTs) involving 1942 women were *** results of review showed low evidence quality that supported the hypothesis the denosumab *** could reduce risk of fracture[OR(95%CI) 1.42(0.84 to 2.40),11 more women per 1000(from 4 fewer to 36 more),p = 0.19] but the moderate to high quality evidence suggesting treatment with 60 mg Den SC Q6M was more effective for postmenopausal women in increasing BMD[at distal radius(DR),total hip(TH),lumbar spine(LS),and femoral neck(FN)].Hazards of neoplasms[OR(95%Cl) 1.10(0.65 to 1.86),3 more per 1000(from 10 fewer to 24 more), p=0.62]or infections[OR(95%CI) 0.95(0.79 to 1.15),12 fewer per 1000(from 53 fewer to 33 more,),p=0.62] were appeared to be *** review suggested within 1 year 60 mg Den SC Q6M treatment was more effective in increasing bone mass but could not reduce the fracture risk to a greater extent than 70 mg Aln QW *** the Den SC Q6M therapy did not increase the risks of neoplasms and infections compared with Aln QW.
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