Objective:This study aimed to evaluate the effects of non-invasive positive pressure ventilation (NIPPV) on oxygenation status and prognosis in patients with acute lung injury induced by paraquat (PQ) ***:From June 20...
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Objective:This study aimed to evaluate the effects of non-invasive positive pressure ventilation (NIPPV) on oxygenation status and prognosis in patients with acute lung injury induced by paraquat (PQ) ***:From June 2011 to August 2012, acute PQ-induced lung injury patients treated with NIPPV were admitted to the Emergency Intensive Care Unit (EICU) at the First Affiliated Hospital of China Medical *** in oxygenation status (respiratory rate, PaO2 and PaCO2) after initial NIPPV were *** in inspiratory pressure (PI) between non-survivors and survivors were *** relationship between PI and the prognosis of patients with acute PQ-induced lung injury was *** : A total of 86 patients (39 males and 47 females) with a mean age of 33.5 24.5 years (range,22 ~61 years) were *** were significant differences in respiratory rate,PaO2 and PaCO2 between before and after initial NIPPV (respiratory rate: 35 ±14 vs.26 16 min-1, P=0.037;PaO2:61.8±19.6 vs.73.5 ±26.8 mmHg, P =0.046;PaCO2: 27.7± 16.4 vs.34.6 19.2 mmHg, P =0.039;respectively).The overall mortality rate was 75.6% (65/86) during a 28-day follow-up *** observed a significant difference in initial PI (PIinitial) between non-survivors and survivors (8.2 ±4.3 cm H2O vs.6.6 3.8 cm H2O, P =0.043).Furthermore, non-survivors had higher maximal PI (PImax) than that of survivors (21.6±9.8 cm H2O vs.15.4±8.5 cm H2O, P =0.022).Correlation analysis revealed that both PIinitial and PImax were associated with poor prognosis in patients with acute PQ-induced lung injury (PIinitial ∶ r =-0.29, P =0.038;PImax ∶ r =-0.31, P =0.042;respectively).Conclusions:Our results indicate that NIPPV with air-indoor may effectively improve oxygenation status of acute PQ-induced lung injury patients, thereby relieving dyspnea and promoting recovery of pulmonary *** PIinitial and PImax may be important determinants of prognosis in patients with acute PQ-induced lung
作者：
Guo-Qiang LiYu-Ming LiLu-Qing WeiYang LiuYu-Hua ZhangDepartment of Intensive Care Medicine
Affiliated Hospital of the Medical College of the Chinese People''s Armed Police ForcesTianjinPeople''s Republic of China Department of CardiologyAffiliated Hospital of the Medical College of the Chinese People''s Armed Police ForcesTianjinPeople''s Republic of China Department of Intensive Care MedicineAffiliated Hospital of the Medical College of the Chinese People''s Armed Police ForcesTianjinPeople''s Republic of China Tianjin Medical University
TianjinPeople''s Republic of China
Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing *** perfusion has recently been incorporated as a method of clinical *** purpose of this study was to estimate the p...
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Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing *** perfusion has recently been incorporated as a method of clinical *** purpose of this study was to estimate the paraquat clearance of plasma perfusion, and observe the effect of plasma perfusion on paraquat concentration in the blood of patients with acute paraquat *** :21 PQ-poisoned patients admitted to our poisoning center within 24 hours after the ingestion were prospectively *** plasma perfusion (flow rate 180 ml/min) was performed, with plasma/blood separation at 40 nl/min and routine cartridges change every 3 *** PQ (UPQ), urine flow rate (UFR), and plasma PQ (PPQ) concentration level at inlet/outlet of the cartridge were obtained right before, and 1.5 hours after the start of each perfusion session for calculation of renal and plasma PQ ***:In all 8 rounds (108 sessions) of plasma perfusion on the 21 patients, PQ clearance rate (ml/min) by plasma perfusion was found always higher than the renal value: [1st (21 cases) 11.14 6.13 vs.6.53 1.46; 2nd (21 cases) 18.36 11.32 vs.6.23 1.51; 3rd (21 cases) 16.13 10.05 vs.4.01 0.93; 4th (17 cases) 12.86 (6.72, 17.47) vs.2.42 (0.65,4.20);5th (11 cases) 14.12 (10.48, 35.20) vs.1.77 (0.63, 2.91);6th (7 cases) 16.47 (t1.82; 20.69) vs.1.70 (0.23, 3.18); 7th (5 cases) 13.33 (9.71, 18.75) vs.1.10 (0.14, 2.99); 8th (5 cases) 11.27 (9.21, 16.02) vs.1.10 (0.09, 2.79), P<0.05 orP<0.01].The survivors (10 cases) showed a higher PPQ reduction rate (mg L-1h-1) than the non-survivors (11 cases, 0.57 0.03 vs.0.47 0.06,P<0.05).Conclusion: Our data show that plasma perfusion therapies help in the clearance of PQ and may prove a promising therapeutic tool in patients with acute PQ intoxication.
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