Background: Following ingestion, dietary triglycerides (TG) are digested, absorbed, resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled...
Background: Following ingestion, dietary triglycerides (TG) are digested, absorbed, resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipoproteins (LP).
Great progresses in the field of Pharmaceutics have been made in China recently,however,there are still many concerns in both basic and applied ***,more and more peoples know that basic research is important,but how w...
Great progresses in the field of Pharmaceutics have been made in China recently,however,there are still many concerns in both basic and applied ***,more and more peoples know that basic research is important,but how we promote the scientific significance and quality of our basic research in Pharmaceutics?We all
Nanotechnology brings great opportunities to solve the problems of drug absoroption and the development of nanoproduct has achieved great ***,the mechanisms of nanocarriers improve drug absorption are limit *** resear...
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Nanotechnology brings great opportunities to solve the problems of drug absoroption and the development of nanoproduct has achieved great ***,the mechanisms of nanocarriers improve drug absorption are limit *** researchers have summarized the main factors influencing the
Drug release from ethylcellulose(EC)-coated pellets exhibits a lag phase-a sbw or non-release phase in the first 1-2 *** objective of the present study was to evaluate the feasibility of using model drug metoprobl suc...
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Drug release from ethylcellulose(EC)-coated pellets exhibits a lag phase-a sbw or non-release phase in the first 1-2 *** objective of the present study was to evaluate the feasibility of using model drug metoprobl succinate(MS)as a pore former to modify
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as...
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as overexpression of ATP-binding cassette transporters (typically, p-glycoproteins, P-gp) and malfunction of ***-penetrating peptide-based strategies were developed for overcoming the barriers against effective cancer drug delivery, through the mechanisms including increased tumor penetration, enhanced intmcellular and intranuclear delivery, prolonged intracellular drug retention, thus yielding promising treatment benefits in the animal models.
Doxorubicin(DOX)is a commonly used chemotherapy drug for treating ***,the severe non-selective toxicity and development of multiple drug resistance(MDR)hinder its clinical ***,it is imperative to devefop a novel drug ...
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Doxorubicin(DOX)is a commonly used chemotherapy drug for treating ***,the severe non-selective toxicity and development of multiple drug resistance(MDR)hinder its clinical ***,it is imperative to devefop a novel drug delivery system,which can not only dehver DOX to tumor sites but also overcome MDR
Background:Following ingestion,dietary triglycerides(TG)are digested,absorbed,resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipop...
详细信息
Background:Following ingestion,dietary triglycerides(TG)are digested,absorbed,resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipoproteins(LP).This provides a potential conduit for drug delivery via the design of prodrugs that mimic the structural intermediates
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