Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,hav...
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Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,have multiple functional groups that are suitable for the bio-conjugation of drugs,signaling groups,and targeting
The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier...
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The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier(BBB).In contrast to oral and parenteral
Plasmonic photothermal therapy(PPTT)is a minimally invasive strategy in which photon energy absorbed by plasmonic nanoparticals is converted to localized heat to destroy *** and adequate tumor destruction by PPTT requ...
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Plasmonic photothermal therapy(PPTT)is a minimally invasive strategy in which photon energy absorbed by plasmonic nanoparticals is converted to localized heat to destroy *** and adequate tumor destruction by PPTT requires a lethal dose of heat to be precisely delivered to the entire tumor and ablative ***,
Objective To develop a novel type of vincristine sulfate(VCR)-baded multifunctional nanoparticles(VCR-Fol/R7 NPs),and to confirm their tumor targeting and multidrug resistance(MDR)characters in vivo and in *** Firstly...
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Objective To develop a novel type of vincristine sulfate(VCR)-baded multifunctional nanoparticles(VCR-Fol/R7 NPs),and to confirm their tumor targeting and multidrug resistance(MDR)characters in vivo and in *** Firstly,in vitro HPLC analysis method was established for VCR detectioa Then VCR-Fol/R7 NPs composed of PLGA-mPEG,PLGA-PEG-Folate,PLGA-PEG-
Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatb...
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Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatbn"states that antiangio genic therapies turn abnormal tumor vessel structure and function return to
Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high ...
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Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high biocompatibility and biological stability.[1]However,the difficulty in their synthesis,low molecular weight,
OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A n...
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OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A new class of multifunctional theranostic agents based on bovine serum
The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid dru...
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The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid drugs from lysosomes and endosomes,we prepared anovel photosensitive carrier(C60-Dex-NH2)
Traditional Chinese medicine in hospital is the foundation of the development of new drug and also a well complement of pharmaceutical *** leadership of maternal and child health hospital of hunan province closely com...
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Traditional Chinese medicine in hospital is the foundation of the development of new drug and also a well complement of pharmaceutical *** leadership of maternal and child health hospital of hunan province closely combines pharmacy and Clinical Journal of Chinese Medicine,set up quality guarantee system in accordance with GMP standard and traditional Chinese
There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug de...
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There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug delivery systems(NDDS)offer many more advantages,which include improved therapy by increasing the efficacy and duration of drug activity,increased
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