Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy a...
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Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy and ***,few people focused on its application in drug delivery and *** this study,we roundly investigated 5 kinds of PHAs(PHB,PHBV,PHBHHx,PHBVHHx and P3HB4 HB,respectively) to prepare microspheres as novel drug carriers for application in drug delivery.
Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to ca...
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Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to cancer may come from a drug stimulus,leading to the overexpression of ATP-binding cassette
PLGA nanoparticbs system has been widely studied in nowadays because of its biocompatibility,biodegradability and ***,there are several drawbacks when applying this system to bad protein or peptide such as insulin due...
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PLGA nanoparticbs system has been widely studied in nowadays because of its biocompatibility,biodegradability and ***,there are several drawbacks when applying this system to bad protein or peptide such as insulin due to fow drug loading and low drug encapsulation efficbncy.
Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)wer...
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Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)were conjugated to poly
Various types of pharmaceutical formulations with drug delivery systems(DDS)have been developed to aid convenience and compliance of patients with treatment along with improvements in the efficacy and safety of DDS[1]...
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Various types of pharmaceutical formulations with drug delivery systems(DDS)have been developed to aid convenience and compliance of patients with treatment along with improvements in the efficacy and safety of DDS[1].Nano-particle(NP)DDS has been widely expected to create new pathways for tumor therapy[2].However,NP-DDS based on new drugs are rare despite the relative research have extensively been *** previous studies,different NP-DDSs were selected,and in situ microscopy imaging and quantitation in single cells was performed in Shanghai Synchrotron Radiation Facility to establish a physiological pharmacokinetic model for these specific NP-DDSs on system,tissue and cellular levels.
The objective of this investigation was to prepare metoprolol tartrate(MT)sustained release pellets coated with Eudragit?NE 30 D and further evaluate their in vitro release and in vivo absorption in beagle *** sustain...
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The objective of this investigation was to prepare metoprolol tartrate(MT)sustained release pellets coated with Eudragit?NE 30 D and further evaluate their in vitro release and in vivo absorption in beagle *** sustained release pellets was
Objective:Star-shaped poly(lactic-co-glycolic acid)polymer terminated with carboxyl acid and chitosan modified with glycyrrhetic acid were successfully *** novel GA-CS/sPLGA complexed microspheres for cucurbitacin B w...
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Objective:Star-shaped poly(lactic-co-glycolic acid)polymer terminated with carboxyl acid and chitosan modified with glycyrrhetic acid were successfully *** novel GA-CS/sPLGA complexed microspheres for cucurbitacin B was constructed(Fig.1),which has the ability to load more drug than the uncomplexed sPLGA microsphere.
*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attent...
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*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attention and offer a promising cancer therapy strategy,as its properties of increasing drug concentration within the
Objective:To develop the colchicine sustained-release capsules,and study its drug release in ***:Sustained-release coating,using Eudragit RS PO and Eudragit RL PO as the sustained-release material,was employed on the ...
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Objective:To develop the colchicine sustained-release capsules,and study its drug release in ***:Sustained-release coating,using Eudragit RS PO and Eudragit RL PO as the sustained-release material,was employed on the celphere to prepare the colchicine sustained-release *** method of release rate determination was used to detect the factors that affect the drug release,and study the drug release mechanism in vitro of coating micropill ***:The drug release process of the micropill capsules accorded basically with the Higuchi equatioa Conclusion:Colchicine sustained-re lease capsules released slowly and steadily in vitro.
Pachtaxel has been approved for treatment of a variety of carcinomas,including ovarian cancer,breast cancer and non-small-cell lung cancer[1].However,its application is limited because of the solvents:Cremophor EL and...
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Pachtaxel has been approved for treatment of a variety of carcinomas,including ovarian cancer,breast cancer and non-small-cell lung cancer[1].However,its application is limited because of the solvents:Cremophor EL and dehydrated ethanol,which caused the side effects including hypersensitivity reactions,nephrotoxicity and
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