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检索条件"任意字段=2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会"

共 272 条记录，以下是111-120 订阅

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Low density lipoprotein receptors mediated lipid emulsion based on paclitaxel-lipid complex for breast tumor target

Low density lipoprotein receptors mediated lipid emulsion ba...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Jun Ye Luhua Meng Xuejun Xia Wujun Dong Yuling Liu Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing Key Laboratory of Drug Delivery Technology and Novel Formulation

Obejective There is a large amount of evidence demonstrating that many tumors have high bw density lipoprotein(LDL)requirements and express relatively high levels of LDL receptors on their *** this account,LDL has ins... 详细信息

关键词： LDL Taxol Low density lipoprotein receptors mediated lipid emulsion based on paclitaxel-lipid complex for breast tumor target PTX

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Bi-directional regulation of the skin permeability of indapamide and bisoprolol in their compound transdermal patch by combining the technique of ion-pair complexation with chemical enhancers

Bi-directional regulation of the skin permeability of indapa...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者：宋文婷方亮 Shenyang pharmaceutical university.Department of Pharmaceutical Science School of Pharmacy

Objective:To achieve the synchronous skin permeation of indapamide(IND)and bisoprolol(BSP),two drugs with totally different skin permeability,the technique of ion-pair complexation and chemical enhancers were combined... 详细信息

关键词： Bi-directional regulation of the skin permeability of indapamide and bisoprolol in their compound transdermal patch by combining the technique of ion-pair complexation with chemical enhancers

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Determination of Paeoniflorin and Tanshinone Ⅱ A in Jiangzhi Fugan capsule by HPLC

Determination of Paeoniflorin and Tanshinone Ⅱ A in Jiangzh...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Li Caidong PAN Xinbo WANG Xin ZHANG Wei The NO.2 people's hospital of Lanzhou Lanzhou institute of Liver disease

Objective:To establish the HPLC methods for the determination of Paeoniflorin and Tanshinone ⅡA in Jiangzhi Fugan ***:A Phenomenex C column was used with the mobile phase of methyl alcohol（31） and 0.1%phosphate acid（69）,the mobile phase of methyl afcohol（75） and 0.1%phosphate acid（25）,Paeoniflorin and Tanshinone ⅡA were detected by ***:The calibration curves were linear in the ranges of 0.448～4.480 μg,0.0576～0.576 μg,*** average recoveries were 99.93%,99.75%with RSDs of 1.98%,1.70%,***:The HPLC methods was simple,accurate and reliable,it could be used for quality control of Jiangzhi Fugan capsule.

关键词： Jiangzhi Fugan capsule Paeoniflorin Tanshinone ⅡA determination

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Synergic Effects of Paclitaxel and Temozolomide co-loaded in mPEG-PLGA Nanoparticles Attenuate Glioblastoma Cells Growth in Vitro and in Vivo

Synergic Effects of Paclitaxel and Temozolomide co-loaded in...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Yuanyuan Xu Ming Shen Ying Sun Yanwei Teng Yourong Duan State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong University

Purpose:This work was conducted to determine the optimal synergic weight ratios of Paclitaxel(PTX)and Temozolomide(TMZ),and further developed a dual drug-loaded delivery system based on mPEG-PLGA nanoparticles(PTX/TMZ... 详细信息

关键词： TMZ Synergic Effects of Paclitaxel and Temozolomide co-loaded in mPEG-PLGA Nanoparticles Attenuate Glioblastoma Cells Growth in Vitro and in Vivo PTX

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Study on Cocrystal and Salt of Triamterene to Improve Solubility

Study on Cocrystal and Salt of Triamterene to Improve Solubi...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： LiAiyan Xu Linlin Jia-Mei Chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University

Triamterene is potassium-sparing diuretics widely used in cardiovascular medications,while poor solubility restrict its appUcation and induce low *** our research,two salts of TAT with mandelic acid(5) and saccharin(6),as well as a few crystal phases including benzoic acid,tartaric acid,Methyl gallate were synthesized by suspend or *** new crystal phases were characterized by single crystal X-ray diffraction,powder X-ray diffraction,differential scanning calorimetry,thermo gravimetric *** solubility of TAT is improved,and the apparent solubility values of TAT/mandelate salt and TAT/saccharinate salt monohydrate in the phosphate buffer of pH 6.8 are approximately 3.2 and 1.2 times as large as that of TAT.

关键词： TAT Study on Cocrystal and Salt of Triamterene to Improve Solubility

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Current Challenges in Developing Oral Disintegrating Tablet Technologies for Pediatric Drug Products

Current Challenges in Developing Oral Disintegrating Tablet ...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Wei-Qin Tong Teva Pharmaceuticals

Today eight out of every ten prescriptions(-80%) in the US are filled with generic *** supply of high quality medication is in the best interest of the industry as well as our *** FDA has made some significant changes to its generic drug review and approval *** include:revision of its QbR questions to sharpen focus on QbD and control strategy,the new stability guideline,and Generic Drug User Fee Amendments(GDUFA),et aL These changes present many new challenges and *** presentation will(1) review the generic product development process and the new FDA requirements;(2) discuss how one may adopt to the new changes and excel in the very competitive generic market;(3) and use case studies to illustrate how QbD principles can be successfully applied to develop high quality generic products with robust manufacturing processes.

关键词： FDA Current Challenges in Developing Oral Disintegrating Tablet Technologies for Pediatric Drug Products

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Advances In The Study of Overcoming Multidrug Resistance In Cancer By Pluronic Block Copolymers

Advances In The Study of Overcoming Multidrug Resistance In ...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Mu liqiu Hu xiongbin Hu yiyun Liu xinyi Li jianhe Xang daxiong Department of Pharmacy the Second Xiangya Hospital of central south university Institute of clinical pharmacyof central south university College of Pharmacy Central South University

Nowadays,tots of investigators draw attention to multidrug res is tance(MDR)in *** MDR is mostly due to the overexpressing of P-glycoprotein(P-gp).In the clinic,strategies for reversing MDR are combined use of P-gp reversal agents or increasing the dose of ***,the reversal agents usually lead to many side-effects,which affect the usage of these ***,developing a safe and effective reversal agent attracts widespread *** has been extensively investigated because of the inhibition on P-gp *** paper describes the mechanism of reversion of MDR by Pluronic,the relationship between copolymer molecular structure,concentration and inhibitory activity,and the novel appUcation of the copolymer.

关键词： Multidrug Resistance MDR Pluronic P-gp

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Research and development of bioadhesive topical film-forming gel drug delivery systems

Research and development of bioadhesive topical film-forming...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者：马晋隆药物制剂国家工程研究中心

Film-forming gel drug delivery systems are novel pharmaceutical dosage forms that present a gel form during preparation and storage and form a smooth and flexible solid film with hydrophobic and bioadhesive characteristics within 30 to 60 seconds after administration,which provides some superior advantages for topical application compared with traditional gel,spray and ointment *** administration to buccal mucosa or dermal surface,the water-proof bioadhesive film formed can be retained at the application site for 5 to 12 hours without interference to daily activities and provide a sustained drug release,which is quite convenient for treatment of oral ulcer and skin *** this report,the formulation ingredients,the film-forming mechanism,the preparation process,the film characteristics and the in vitro and in vivo evaluation methods of this dosage forms will be introduced using a specific example of film-forming amlexanox oral *** practical advantages and potential applications will also be discussed.

关键词： Research and development of bioadhesive topical film-forming gel drug delivery systems

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The development and industrialization of osmotic pump tablets

The development and industrialization of osmotic pump tablet...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者：谈邹念国家药物制剂工程研究中心

The osmotic pump tablets(OPT) have gained an extensive attention over the past decades and a number of commercial products have been available on the market,mainly due to the facts that OPT can provide a zero order drug release and the in vivo retease is generally not affected by physiobgical ***,because of the complex processing technology and lack of the key excipients and high efficiency domestic drilling and inspection equipments,the industrialization of OPT in our country fell behind the overseas developed *** the first domestic laser drilling machine for OPT was designed and manufactured by National Pharmaceutical Engineering Research Center over 10 years ago,great changes have taken place in this research *** this report,the research and devebpment experience of OPT in our research center will be shared;especially the development of laser drilling and inspection machine for large scale productbn will be ***,the potential prospect of OPT will also be discussed.

关键词： OPT The development and industrialization of osmotic pump tablets

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Development of a nanoparticles-in-microparticles system of docetaxel

Development of a nanoparticles-in-microparticles system of d...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Li Bo Li FengQian Department of Pharmacy Shanghai Eighth People's Hospital

Objective:To prepare docetaxel（DTX） loaded nanoparticles-in-microparticles system（NiMS）.Methods:With chiosan being used as the carrier,three kinds of different feed ratio of DTX-NiMS were prepared by ionotropic gelation technique combined with spray-drying ***,drug loadings entrapment efficiency and drug release property in vitro were investigated by *** morphology and surface of the spray-dried NiMS were examined by scanning electron microscopy while the particle diameter was studied by dry disintegration laser ***:The prepared microparticles were spherical,with diameters ranging from l0μm,Three kinds of drug entrapment efficiency were（77.07±2.50）%、（72.88±2.50）%、（92.39±0.77）%,respectively,and the loading capacity were（8.58±0.29）%、（14.58±0.50）%、（39.60±0.32）%.The drug release profile of both original DTX and DTX-NiMS in vitro were very slow,all of them the drug release profile were less than 8%in 144 *** DTX-NiMS released rather slowly compared to original ***:DTX-NiMS with satisfactory drug loading capacity and entrapment efficiency,the drug release slow were successfully prepared by using this method.

关键词： docetaxel chitosan nanoparticles-in-microparticles ionotropicgelation process spray drying

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