D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS or Vitamin E TPGS)is a water-soluble derivative of natural Vitamin E,which is formed by esterification of Vitamin E succinate with polyethylene glycol(PEG)*** re...
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D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS or Vitamin E TPGS)is a water-soluble derivative of natural Vitamin E,which is formed by esterification of Vitamin E succinate with polyethylene glycol(PEG)*** recent years,TPGS has been applied in drug delivery systems since it is an FDA approved pharmaceutically
Aim: To develop a theranostic nanoemulsion (TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB).Materials & methods: The TNE was es...
Aim: To develop a theranostic nanoemulsion (TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB).Materials & methods: The TNE was established using core-matched technology, and can achieve high encapsulation efficiency and synchronized release of the loaded *** has been examined for a correlation between the dynamic uptake of PTX and the intensity of SRB imaging signal in different *** & discussion: Our data denonstrates that the TNE, with improved circulation time, increases therapeutic efficacy and imaging efficiency in both drug-sensitive and drug-resistant *** TNE could not satisfy the demand of visual diagnosis in the living animal because of *** therefore formulated a long-circulating theranostic nanoemulsion (LCTNE).Results showed that the LCTNE can meet imaging requirements in ***: The LCTNE increases therapeutic efficacy and imaging efficiency for both tumor types *** LCTNE plays a good therapeutic and diagnostic role for subcutaneous tumors in the living *** The LCTNE reported here provides insights into the development of new theranostic nanocarriers for the treatment of MDR in cancer.
Oral dissolvable films(ODFs) are film-like novel pharmaceutical dosage forms about the size of a small postage stamp,composed of active pharmaceutical ingredients and other suitable *** has gained a great popularity i...
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Oral dissolvable films(ODFs) are film-like novel pharmaceutical dosage forms about the size of a small postage stamp,composed of active pharmaceutical ingredients and other suitable *** has gained a great popularity in recent years at home and abroad due to its pharmaceutical advantages,such as rapidly dissolving and release properties,convenient to use without water,quite suitable for children and old patients,small amount of excipients used,nearly no powder dust during manufacturing,etc,and a number of ODFs products are available on the foreign ***,this novel ODFs is not yet for clinical use in China although the traditional film dosage forms were recorded in Chinese Pharmacopoeias firstly in the *** fabrication process and the quality standards have been systemically studied,and the novel manufacturing equipments have been designed and developed for film-forming,film-cutting and packaging in National Pharmaceutics Engineering Research *** this report,the preparation and packaging of ODFs both for laboratory and scale-up,and the in vitro and in vivo evaluation methods are introduced using a few *** addition,the research,application and potential prospect of ODFs are also discussed.
In the past several years,gene therapy has received significant attention due to its potential application in the replacement of dysfunctional genes and treatment of acquired ***,naked gene molecules that are negative...
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In the past several years,gene therapy has received significant attention due to its potential application in the replacement of dysfunctional genes and treatment of acquired ***,naked gene molecules that are negatively charged due to their phosphate groups susceptible to serum nucleases,renal clearance,and non-targeted biodistribution,making it difficult to access the cellular target sites of delivered ***,the development of gene carriers,which can be made into nano-sized complexes to protect naked gene molecules,is ***,for safe and efficient gene delivery,gene carriers should overcome the conventional limitations,such as poor stability,short half-life,and tow transfection ***,a natural cationic polysaccharide,has been investigated as one of non-viral vectors because it has some advantages such as biocompatibility,btodegradability and low toxicity with high cationic ***,low transfection efficiency and tow cell specificity of chitosan as a DNA or small interfering RNA(siRNA) carrier need to be overcome for clinical ***,we exploited some biocompatible chitosan derivatives such as chitosan-g-PEI,chitosan-g-spermine,chitosan-g-metformine based on the Schiff-base for enhancement of transfection efficiency as well as more functionality.
Despite decades of research and drug development for cancer treatment,cancer still remains one of the major causes of human deaths in the *** cancers consist of a mixed population of malignant cells that carry multipl...
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Despite decades of research and drug development for cancer treatment,cancer still remains one of the major causes of human deaths in the *** cancers consist of a mixed population of malignant cells that carry multiple genetic *** of them are driver mutations that determine tumor initiation,progression,and *** genomic landscapes indicate that multiple signal transduction pathways determine the fete of a cancer cell,and it is almost impossible to treat cancer with a single therapeutic ***,there is an urgent and persistent motivation to devefop novel therapeutics independent of the genetic background of the cancer in the fight against this deadly *** ablation(PTA)therapy is a recently developed technique that uses near-infrared(NIR) laser light-generated heat to destroy tumor *** has gained popularity recently because a specific amount of photoenergy is delivered directly into the tumor mass without causing systemic effects,thus promising minimally invasive intervention as an alternative to ***,PTA therapy alone is unlikely to kill all tumor cells because the heat distribution is nonuniform,especially in areas peripheral to large blood vessels where heat can be rapidly dissipated by circulating *** improve the efficacy and tumor selectivity of laser-induced PTA,light-absorbing photothermal conducting nanoparticles are *** principle,NIR laser-modulated photothermal effects can not only enable PTA of tumor cells but also trigger release of anticancer *** a multimodal approach,which permits simultaneous PTA therapy and chemotherapy,should provide an opportunity for complete eradication of tumor cells.
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