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检索条件"任意字段=2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会"

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Hyaluronic acid based nanoparticle incorporating dichloro(1,2-diaminocyclohexane) platinum(Ⅱ) for tumor-targeted drug delivery

Hyaluronic acid based nanoparticle incorporating dichloro(1,...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Lin Kang Xiuquan Quan Zhonggao Gao State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Affiliated Hospital of Yanbian University

Background cis-dichlorodiammineplatinum(Ⅱ)(cis-platin,CDDP),a widely used anticancer drug,shows acute dose-related side ***(1,2-diaminocyclohexane) platinum(II)(DACHPt),a CDDP analogue,has shown lower toxicity than CDDP and no cross-resistance with CDDP in many CDDP-resistant ***,the solubility of DACHPt in water is much lower than CDDP(0.25 mg/ml for DACHPt vs.1.2 mg/ml for CDDP).Recently,many drug delivery systems have been developed to enhancing water solubility of DACHPt[l].Hyaluronic acid(HA) is a naturally occurring nonsulfated glycosaminoglycan polysaccharide with multiple biological activities and excellent biocompatibilty and biodegradability,HA and its derivatives have been popularly used as temporal scaffolds for tissue engineering and drug delivery devices for therapeutic agents[2].Objective In this study,we explored the potential possibility of methoxy polyethylene glycol(mPEG) modified HA as a biocompatible,biodegradable,and non-cytotoxic material for delivery of *** and Results Novel nanoparticle entrapping DACHPt was prepared through the polymer-metal complex formation between DACHPt and mPEG-HA in distilled water after converting DACHPt to its aqueous complex by pretreatment with AgN03(Fig.1).The mPEG modified degree of HA was determined by IH-NMR measurement(Fig.2).Subsequently,the physical and chemical properties of DACHPt/NP were *** average diameter of the nanoparticle was44.75nm(PDI=0.298).Moreover,the in vitro cytotoxicity against human non-small-cell lung carcinoma(A549) cells was ***,the targeting ability and therapeutic efficiency was confirmed by systemically injected DACHPt/NP against a experimental model of lung *** DACHPt-loaded nanoparticle showed small enough to achieve extended blood *** in vitro cytotoxicity assay against the A549 cell line showed a low IC50 value to expect high therapeutic ***,in vivo cytotoxicity against lung

关键词： Hyaluronic acid based nanoparticle incorporating dichloro diaminocyclohexane for tumor-targeted drug delivery platinum

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In situ thermo-sensitive gel with multitarget anticancer functions:an effective alternative strategy to clinical administration for remaining high efficacy and reducing toxicity

In situ thermo-sensitive gel with multitarget anticancer fun...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Hongxiang Hu Zhiqiang Lin Bing He Hua Zhang Qiang Zhang Skate Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

Nowadays combining chemotherapeutic drug Paclitaxel(injected) with Lapatinib(oral),a tyrosine kinase inhibitor,has already been used as an effective therapy against breast cancer overexpressing HER2(Human Epidermal Growth Factor Receptor 2).In addition to improved antitumor effect,toxicity generated mainly from systematic administration of the two drugs is another aspect people concern ***,we use in situ thermo-sensitive hydrogel,F127,as a local delivery carrier incorporating Paclitaxel and Lapatinib to substitute for clinical administration with the purpose of decreasing toxicity and maintaining effect *** order to achieve stable and sustained release of drugs,we adopted strategy to incorporate PTX-NCs(Paclitaxel nanocrystals) and LAPA-MCs(lapatinib microcrystals) into the geL To investigate the effect of combination therapeuty,we chose three different kinds of cells(MCF-7/P-gp- HER2-,BT474/P-gp- HER2+,MCF-7-ADR/P-gp+ HER2+) to test their combined *** we found that the two drugs worked most effective in MCF-7-ADR and poorest in MCF-7,which meant the combined activity was likely connected with overexpression of P-gp and *** result corresponded with the previous investigation about *** also demonstrated that the phenomenon may be connected with cellular *** BT474 tumor-bearing mice as an animal model,we injected the gel containing two drugs(PTX-LAPA-gel) into the surrounding of tumors to observe its antitumor efficacy and toxicity with controls of PTX-gel,LAPA-gel and PTX-gel-LAPA-oraL As predicated,PTX-LAPA-gel was almost as effective as PTX-gel-LAPA-oral and obviously superior to other *** can also draw this conclusion from the result of induced apoptosis and anti-angiogenesis of these ***,PTX-LAPA-gel revealed less toxicity than PTX-gel-LAPA-oral because of its little drug distributing to other organs,which was demonstrated by analyzing the distribution of the two kinds of administratio

关键词： PTX MCF In situ thermo-sensitive gel with multitarget anticancer functions:an effective alternative strategy to clinical administration

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Liposomes coated with N-trimethyl chitosan improve the absorption of harmine-in vivo and in vitro

Liposomes coated with N-trimethyl chitosan improve the absor...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Weiliang Chen Zhiqiang Yuan Shudi Yang Xue-nong Zhang Department of Pharmaceutics College of Pharmaceutical ScienceSoochow University

Objective:To improve the absorption of an anti-tumor drug,harmine（HM） by encapsulating it into liposomes and further coated with N-trimethylchitosan（TMC）.Methods:Harmine liposomes（HM-lip） were prepared by the thin film hydration- pH gradient ***-lip were coated with TMC to prepare *** properties,release,pharmacokinetics and retention behavior in gastrointestinal tract of HM-lip and TMC-HM-lip were *** degradation of HM,HM-lip and TMC-HM-lip in Caco-2 cell homogenate were *** transport across caco-2 cell monolayers of HM,HM-lip and TMC-HM-lip were ***:As shown in Fig.2,the release of HM showed a pH-dependence and HM released much stower from HM-lip and TMC-HM-lip in pH 6.8 and pH 7.4 PBS,but rapidly in *** from fig.3,the bioavailability of HM ig was as low as 29.16%,while that of HM-hp and TMC-HM-lip increased to 50.93%and 73.11%*** is interesting but unusual that the plasma concentration-time curve of HM-lip and TMC-HM-lip showed *** reason may due to the difference in gastric emptying or absorption speed between HM and *** behavior of Dir-lip and TMC-Dir-lip in gastrointestinal tract It can be indicated from fig.5 that the compositions of liposomes may cause the delaying of HM in gastric emptying and TMC-HM-lip moved even slower than *** shown in Fig.6,the degradation of HM in Caco-2 cell homogenate was last,while that of HM-lip and TMC-HM-lip was much *** is indicated that liposomes could protect HM from the degradation by the enzymes in the gastrointestinal tract As shown in fig.8 that for HM,Papp < Papp,which prompted that the transport of HM across Caco-2 cell monolayers might be effected by ***,HM-lip could improve the transport of HM and TMC-HM-lip further improved the transport of *** shown in fig.9,the reduction of TEER was more than 30%when caco-2 cell monolayer treated with TMC-HM-lip and TMC,of which the reason might be that t

关键词： harmine liposomes N-trimethyl chitosan pharmacokinetics caco-2 cell mpnolayers oral adminiatration

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Novel 4-Arm-PEG-TPGS Amphiphilic Copolymer Micelles Loading Paclitaxel:Preparation,Characterization,and Evaluation

Novel 4-Arm-PEG-TPGS Amphiphilic Copolymer Micelles Loading ...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Yupei Wu Songwei Tan Xiangting Zhuang Yuling Bao Tingting Wu Zhiping Zhang Tongji School of Phamarcy Tongji Medical CollegeHuazhong University of Science &Technology

Over the past few decades,the exploitation of branched PEG modified biocompatible and biodegradable polymers has received considerable *** polymers containing both hydrophobic and hydrophilic segments are of particular interest for biomedical applications,such as drug *** this study,new amphiphilic block copolymers,4-arm poly(ethylene glycol)-block-tocopheryl polyethylene glycol succinate(4-arm-PEG-C-C-TPGS、 4-arm-PEG-S-S-TPGS) with different molecular weight of 4-arm-PEG(5K、10K、20K) were synthesized to as potential paclitaxel(PTX) *** obtained copolymers were characterized by 1H NMR and gel permeation chromatography(GPC).Both the results indicated that TPGS was successfully grafted onto 4-arm-PEG with the CMC value of about 10-2 mg/*** were loaed into the micelles by a solid dispersion *** drug loading content and encapsulation efficiency of the micelles were 11.96%and 71.80%for4-arm-PEG5k-TPGS,which was much higher than that of 4-arm-PEG10k-TPGS(4.88%and 32.53%) and 4-arm-PEG20k-TPGS(5.29%and 35.27%).TEM showed that the micelles were spherical with a hydrodynamic diameter of about 200 *** PTX-loaded 4-arm-PEG5k-TPGS micelles were stable and the diameter remained unchanged more than 72 h both in PBS and fetal bovine serum(37oC).The IC50 value of the PTX-loaded 4-arm-PEG5k-C-C-TPGS micelles against A2780、A549、MCF-7were much lower than the one of *** was also found out that PTX-loaded4-arm-PEG5k-C-C-TPGS micelles did much better than PTX in vivo antitumor activity.

关键词： 4-Arm-PEG-TPGS paclitaxel micelle

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Dual-functional biomimetic nanovector based on pH-responsive cell-penetrating peptide and high-density lipoproteins for apoptotic antitumor therapy

Dual-functional biomimetic nanovector based on pH-responsive...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Yang Ding Yazhe Wang Jianping Zhou State Key Laboratory of Natural Medicines Department of PharmaceuticsChina Pharmaceutical University

The central dogma of drug delivery is to steer therapeutic cargos to target tissues and/or cells to achieve maximal therapeutic efficacy with minimal toxic *** of biomimetic designs as promising sustained drug release and site-targeted delivery systems for a variety of therapeutic agents from different fields of cancer therapy has gained a remarkable degree of interest in recent ***,we introduce a robust dual-functional cell-penetrating peptide(CPP)/recombinanted high-density lipoproteins(cp-rHDL)-based delivery system that affords high payload and efficient delivery of a natural compound gambogic acid(GA),which could enhance proteasome inhibitor-induced anticancer activity due to pleiotropic apoptotic effects through a complex mechanism involving the participation of multi-molecular ***-encapsulated cp-rHDL nanoparticles(cp-rHDL/GA) consists of(1)hydrophobic core for modulation of the anticancer therapeutic GA,(2) apolipoprotein(apoA-I) with attractive integrating and packaging ability,and(3) stearyl CPP anchored into phospholipid monolayer due to hydrophobic *** tailored nanosystem cp-rHDL/GA presents desirable particle size(128.3 ± 5.3) nm,excellent entrapment efficiency(95%for GA),superior biostability,and favorable buffering capacity leading to proton sponge *** stably assembled cp-rHDL/GA was fabricated by introduce of apoA-I,which enabled targeted connection to scavenger receptor BI(SR-BI) resulting in directly cytosolic GA delivery,and tumor acidity-responsive CPP(R6H4) responsible for controllable permeability through an endocytotic pathway with ability of rapid endo-lysosomal escape(designated SR-BI "channel" /endo-lysosome co-mediated intracellular mechanism).Upon stepwise incubation with apoA-I and R6H4,cp-rHDL/GA enhanced cell interaction of 96.1%positive human hepatic carcinoma(HepG2) cells atpH6.4,and remarkable cytotoxicity and apoptotic effect via triggering p53 pathway,approximately 4.5-fold increa

关键词： Dual-functional biomimetic nanovector based on pH-responsive cell-penetrating peptide and high-density lipoproteins for apoptotic antitumor therapy

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Synthesis and characterization of low-density lipoprotein modified poly-N-succinyl chitosan lipoic acid and its micelles

Synthesis and characterization of low-density lipoprotein mo...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Shu-di Yang Xue-nong Zhang Department of Pharmaceutics College of Pharmaceutical ScienceSoochow University

Objective:In this paper,we report on reduction and pH dual-sensitive reversibly core-cross linked micelles based on N-succinyl chitosan lipoic acid micelles(NSC-LA.) and which are modified with LDL(LDL-NSC-LA).Paclitaxel(PTX) was used as a model drug,NSC-LA and LDL-NSC-LA as carriers,and MCF-7,a common human breast cancer cell line,as a cell model to explore the effects and preliminary mechanisms of Taxol and it's micelles in inhibiting breast cancel cells' ***:(1) LDL was isolated from human plasma by density gradient ultracentrifugation adjusted with *** and characters of Paclitaxel(PTX)were investigated.(2)NSC-LA and LDL-NSC-LA polymeric micelles was synthesized and characterized by FT-IR,1H-NMR and Raman,*** preparation was prepared by prepare LDL-coupled micelles(PTX/LDL-NSC-LA) via mild condensation *** the release behavior of polymeric micelles was determined in different release media in vitro.(3) The MCF-7 cell model in vitro was *** assay was used to determine the cytotoxicity in vitro of Taxol,two kinds of Taxol modified micelles and LDL loaded blank ***:LDL was isolated from fresh human plasma by sequential density gradient ultracentrifugation with a size distribution of(23.6±0.86)*** find the dialysis method is the best way to prepare the drug loaded *** ratio of LA was 10.11%and CMC was7.07xlO-3mg/*** mean particle size of PTX/LDL-NSC-LA was(172.0±5.5)nm,The mean particle size of polymeric micelles was(2.3±0.6)nm after adding DTT for 8.5 hours,zeta potential was(-22.57±0.40) mV;Encapsulation was 93.9%and the Drug foading of NSC-LA was 14.4%.The in vitro release studies showed that PTX release from NSC-LA micelles at pH7.4 and 37℃ was significantly inhibited by crosslinking(*** than 30%release in 72 h).The release of PTX was,however,almost doubled under endosomal pH of *** particular,rapid PTX release was observed under a reductive condition containing 10 mM glutath

关键词： Paclitaxel Low-density lipoprotein N-succinyl chitosan lipoic acid polymeric micelles reduction-Sensitive pH-Sensitive Intracellular Drug Release

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Overcoming drug resistance of tumor cells by altering intracellular distribution of doxorubicin

Overcoming drug resistance of tumor cells by altering intrac...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Min Han Hui-Na Liu Ming-Yi Huangfu Zhi-Lan Chen Afsaneh Lavasanifar Jian-Qing Gao College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China. Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta

Drug resistance is one of the critical reasons leading to failure in *** studies have been focused on increasing intracellular drug accumulation through inhibiting P-glycoprotein(Pgp).In this study,doxorubicin(DOX) was delivered specifically to mitochondria by conjugating to a lipophilic triphenylphosphonium(TPP),or to nucleus by a polyamidoamine(PAMAM) dendrimers functionalized with a polysaccharide hyaluronic acid(HA) containing major vault protein(MVP) targeted smalt interfering RNA(MVP-siRNA).The effect of TPP modification on DOX cell uptake,intracellular trafficking,eventual DOX induced cytotoxicity,and the level of cleaved caspase 3 and PARP in wild type MDA-MB-435/WT and DOX resistant MDA-MB-435/DOX cells was then evaluated and compared to that for free *** general,free DOX cellular uptake appeared to be significantly higher in MDA-MB-435/WT than MDA-MB-435/DOX ***,free DOX was able to enter the nucleus of MDA-MB-435/WT cells,but in MDA-MB-435/DOX cells,it was confined within the *** TPP-DOX,on the other hand,was localized in the cytoplasm of both cell phenotypes and showed preferential distribution to the ***,in MDA-MB-435/DOX cells,an enhanced cytotoxicity was observed for TPP-DOX(IC50 of 33.6 and 21.0 uM at 48 and 72 h incubation,respectively)in comparison to free DOX(IC50 of 126.7 and 77.96 uM at 48 and 72 h incubation,respectively).This observation was accompanied with the increased level of cleaved caspase3 and PARP indicating enhanced apoptosis in both cell lines particularly that of MDA-MB-435/DOX for TPP-DOX compared to free DOX following 24 h ***,MVP maybe transport DOX from the action target(***) to cytoplasma in drug resistance tumor cells,herein,polyamidoamine(PAMAM) dendrimers was functionalized by a polysaccharide hyaluronic acid(HA) to effectively deliver DOX as well as MVP targeted small-interfering RNA(MVP-siRNA) to down regulate MVP expression and imp

关键词： drug resistance intracellular distribution mitochondrion nucleus Small-interfering RNA doxorubicin(DOX)

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Cytotoxicity and Cellular uptake of Tumor-targeted nanoparticles derived from pullulan acetate conjugate

Cytotoxicity and Cellular uptake of Tumor-targeted nanoparti...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： JIA Ya-jing CHEN Hong-li TANG Hong-bo ZHOU Zhi-min XING Xue-kun ZHAO Liang School of Life Science and Technology Xinxiang Medical University Department of Pharmacy Beijing Obstetrics and Gynecology HospitalCapital Medical University Institute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College

Objective Folate receptors(FRs),over-expressed on the surface of a variety of tumor cells,are potential targets for tumor targeting *** is to continue our earlier work on the folate conjugated pullulan acetate nanoparticle(FPA NP),which were further used as an Epirubicin(EPI) carrier to enhance cancer targeting *** aim of the present work was to clarify the mechanism of FPA NP internalized by cancer cells,which provides the basis for developing more safe and effective nano-sized drug *** FPA NP and FPA/EPI NP were prepared by dialysis *** cytotoxicity of FPA/EPI NP against HepG2 cells and He la cells was evaluated by MTS *** cellular uptake of the FPA/EPI NP was systematically evaluated by fluorescence intensity which detected by flow ***,several selective endocytosis inhibitors(chlorpromazine,flipin,chloroquineto) and folate were selected to study the potential endocytosis *** FPA/EPI NP was successfully formulated into nanoparticles(mean particle size 268.5±12.0nm) by dialysis with an almost spherical *** assay revealed that FPA/EPI NP showed cytotoxicity against HepG2 and Hela cells,and at72 h the half maximal inhibitory concentration(IC50) of FPA/EPI NP were 168 μg/mL and 105 ng/mL,*** vitro experiments with endocytic inhibitors revealed that clathrin-mediated endocytosis and macropinocytosis were involved in the internalization of FPA/EPI NP on the HepG2 *** clathrin- mediated endocytosis and FRs-mediated endocytosis were involved in the internalization of FPA/EPI NP on the Hela *** Our FPA NP may serve as a drug carrier for tumor target therapy.

关键词： Pullulan Folate receptors Nanoparticles Tumor target Cell uptake

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Inhibition mechanism of P-glycoprotein mediated efflux by a novel S-protected thiolated chitosan

Inhibition mechanism of P-glycoprotein mediated efflux by a ...

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2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Xianhui Chen Bing He Hua Zhang Wenbing Dai Xueqing Wang Qiang Zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

Nowadays,a novel thiolated chitosan and its S-protected derivative have attracted broad attention for their permeation enhancing and efflux pump inhibitory *** to chitosan,the permeation enhancing properties of thiolated chitosan is related to its effect on tight junctions,and the mechanism has been ***,the efflux pump inhibitory mechanism that is related to its effect on P-glycoprotein(P-gp) remains *** present study aimed to investigate the effect of the thiolated chitosan,chitosan-thioglycolic acid(CS-TGA),and its S-protected derivative(CS-TGA-6MNA) on the activity of P-glycoprotein(P-gp) and unravel the action *** the synthetic process,thioglycolic acid(TGA) were first covalently bound to chitosan(CS),then thiol groups of thiolated chitosan were protected by disulfide bond formation with the thiolated aromatic residue6-mercap to nicotinamide(6-MNA).P-gp inhibition effects were evaluated ex vivo using rat intestinal mucosa and in vitro via Caco-2 cells using the known P-gp substrate rhodamine-123(Rho-123) as the model drug.S-protected thiolated chitosan exhibited pronounced P-gp inhibition effects in contrast to chitosaa The fluorescence polarization measurement results suggested the plasma membrane fluidization was a contributor for inhibition of P-gp by S-protected thiolated chitosaa At the same time,S-protected thiolated chitosan inhibited P-gp ATPase *** evident change in P-gp express level was detected by flow cytometry after exposure of the cells to S-protected thiolated chitosaa The depletion of intracellular ATP,which was likely to be a result of partial inhibitionof cellular metabolism,was directly correlated with inhibitory potential for P-gp mediated efflux by S-protected thiolated chitosaa Thus,the efflux pump inhibitory properties appeared to the integrated results of plasma membrane fluidization alteration,intracellular ATP-depletion and P-gp ATPase activity *** features approve S-p

关键词： Inhibition mechanism of P-glycoprotein mediated efflux by a novel S-protected thiolated chitosan

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Arsenic trioxide-loaded pH-responsive mesoporous silica nanoparticles:preparation,in vitro release and pharmacokinetic studies in rats

Arsenic trioxide-loaded pH-responsive mesoporous silica nano...

引用

2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Manman Guo Guowei Wang Jiani Guan Junjun Xu Fanzhu Li Zhejiang Chinese Medical University College of Pharmaceutical Science

Objective To prepare arsenic trioxide-loaded pH-responsive mesoporous silica nanoparticles（PAA-ATO-MSNs） and investigate their physicochemical properties,release behavior in vitro and pharmacokinetics in rats,in order to achieve pH-responsive and sustained release of PAA-MSNs as carrier for *** PAA was covalently attached to the exterior surface of amino group functionalized MSNs prepared by sol gel *** electron microscope（TEM）,small angle X-ray diffraction（XRD）,nitrogen adsorption,and laser particle size analyzer were used to determine the physicochemical *** Entrapment efficiency（EE） and drug loading（DL） of PAA-ATO-MSNs were investigated with the method of high speed centrifugation combined with inductively coupled plasma emission spectrum（ICP）.The drug release behavior of PAA-ATO-MSNs was studied using dynamic dialysis method,PBS（pH 5.8,7.4,and 9.0） chosen as release *** ATO-Sol as control,the pharmacokinetic behavior of PAA-ATO-MSNs after intravenous injection in rats were *** concentration of ATO was determined by inductively coupled plasma mass spectrometry（ICP-MS）.Results Morphology of MSNs was spherical with obvious mesoporous *** area of MSNs was 572.2783 m2-g-1 and the pore size was 2.56 *** obvious diffraction peak occurred between 2-3°.The mean particle size,Zeta potential,EE and DL of PAA-ATO-MSNs were（148.6±0.30） nm,（-27.83±0.34） mV,（40.95±3.21）%,（11.42±1.75）%,*** vitro release behavior of PAA-ATO-MSNs has pH-responsive *** main pharmacokinetic parameters of ATO-Sol group and PAA-ATO-MSNs group were as follows:Tl/2a were（39.35 ±8.50） and（29.03±4.63） min,T1/2β were（1940.86 ±14.20） and（6381.5±35.67） min,AUC0→∞ were（3080.47±18.83） and（9069.86±21.36）μg·min·mL,AUC0→twere（706.72±9.17） and（1122.55±31.40） μg·min·mL,CL were（0.25±0.03） and（0.033±0.004） L·h·1,*** PAA-ATO-MSNs were successfully prepared with well-distributed particle size,high entr

关键词： arsenic trioxide PAA-MSNs in vitro release pharmacokinetic

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